Department of Biochemistry and Molecular Biology

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Past McLean Lectures

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2019 (47th Lectures) 

  • Nahum Sonenberg, Ph.D., Gilman Cheney Chair in the Department of Biochemistry and the Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada 
  • Michael N. Hall, Ph.D., Professor and former Chair of Biochemistry, Biozentrum of the University of Basel, Switzerland 
  • Download the 47th McLean Lectures Brochure

2018 (46th Lectures)

  • Tony Hunter, Ph.D. American Cancer Society Professor Renato Dulbecco Chair Molecular and Cell Biology Laboratory The Salk Institute for Biological Studies
  • Susan S. Taylor, Ph.D. Senior Fellow, San Diego Supercomputer Center Investigator, Howard Hughes Medical Institute Professor, Department of Pharmacology Professor, Department of Chemistry & Biochemistry University of California, San Diego
  • Download the 46th McLean Lectures Brochure

2017 (45th Lectures)

  • Peter Walter, Ph.D. Distinguished Professor Department of Biochemistry and Biophysics Howard Hughes Investigator University of California, San Francisco, Calif.
  • F. Ulrich Hartl, M.D., Ph.D. Professor Department of Cellular Biochemistry Max Planck Institute of Biochemistry Martinsried Germany
  • Download the 45th McLean Lectures Brochure

2016  (44th Lectures)

  • Jennifer A. Doudna, Ph.D. Departments of Molecular and Cell Biology and Chemistry, UC Berkeley Howard Hughes Medical Institute Lawrence Berkeley National Lab National Academy of Sciences American Academy of Arts and Sciences
  • Richard Henderson, Ph.D. Programme Leader Fellow of the Royal Society Foreign Associate of the U.S. National Academy of Sciences MRC Laboratory of Molecular Biology
  • Download the 44th McLean Lectures Brochure

2015 (43rd Lectures)

  • Arthur L. Horwich, M.D., Professor, Department of Genetics, Yale University School of Medicine Howard Hughes Medical Institute Investigator, Member of the National Academy of Sciences
  • Xiaowei Zhuang, Ph.D., Professor, Departments of Physics, Chemistry & Chemical Biology Harvard University, Howard Hughes Medical Institute Investigator, Member of the National Academy of Sciences
  • Download 43rd McLean Lectures brochure

2014 (42nd Lectures)

  • Randy Schekman, Ph.D. Professor, Department of Molecular and Cellular Biology University of California, Berkeley Howard Hughes Medical Institute Investigator Member of the National Academy of Sciences Nobel Laureate
  • Beth Levine, M.D. Professor of Internal Medicine and Microbiology UT Southwestern Medical Center, Dallas Howard Hughes Medical Institute Investigator Member of the National Academy of Sciences
  • Download 42nd McLean Lectures brochure

2013 (41st Lectures)

  • Melanie Cobb, Ph.D., National Academy of Sciences Member, Jane and Bill Browning, Jr., Endowed Chair in Medical Science, Professor, Department of Pharmacology, UT Southwestern Medical Center
  • Brian Kobilka, M.D., Nobel Laureate, Professor, Departments of Medicine, Cardiology, and Molecular and Cellular Physiology, Stanford University
  • Download 41st McLean Lectures brochure

2012 (40th Lectures)

  • Sir Alan Fersht, Cambridge University, "Tumour Suppressor P53 - from Structure to Drug Discovery"
  • Dr. Roger Y. Tsien, University of California, San Diego, "Breeding and Building Molecules to Spy on Cells and Disease Processes"
  • Download 40th McLean Lectures brochure (PDF)

2011 (39th Lectures)

  • Dr. David S. Eisenberg, University of California, Los Angeles, "The Amyloid State of Proteins in Health and Disease"
  • Sir Tom Blundell, University of Cambridge, "Genomes, Structural Biology and Drug Discovery"

2010 (38th Lectures)

  • Jack W. Szostak, Harvard Medical School, "What We Can Learn About the Origins of Life from Efforts to Design an Artificial Cell"
  • Dr. Charles Elachi, California Institute of Technology, "The Excitement of Space and Earth Exploration"

2009 (37th Lectures)

  • Dr. Stephen J. Elledge, Harvard Medical School, "Genetic Mining of the Cancer Genome"
  • Dr. Francisco J. Ayala, University of California, "Evolution and Creationism"

2008 (36th Lectures)

  • Dr. Cynthia J. Kenyon, University of California, San Francisco, "A Regulatory Network that Governs Aging"
  • Dr. Leonard P. Guarente, Massachusetts Institute of Technology, "Sirtuins, Calorie Restriction and Longevity"

2007 (35th Lectures)

  • Dr. Richard A. Young, The Broad Institute of MIT and Harvard University, "Regulatory Circuitry of Human Embryonic Stem Cells"
  • Dr. Eric F. Wieschaus, Princeton University, "Understanding Embryonic Development"

2006 (34th Lectures)

  • Dr. David P. Bartel, Whitehead Institute for Biomedical Research, "Small RNAs that Regulate Gene Expression"
  • Dr. Peter C. Agre, Duke University, "Aquaporin Water Channels: From Atomic Structure to Clinical Medicine"

2005 (33rd Lectures)

  • Dr. C. David Allis, Rockefeller University, "Beyond the Double Helix: Writing and Reading the Histone Code"
  • Dr. Susan L. Lindquist, Whitehead Institute for Biomedical Research, "Self-Perpetuating States in Biology"

2004 (32nd Lectures)

  • Dr. Ronald W. Davis, Stanford University, "Technology Development for Yeast Functional Genomics and Translational Medicine"
  • Dr. Robert J. Lefkowitz, Duke University, "Seven Membrane Spanning Receptors"

2003 (31st Lectures)

  • Dr. Irving L. Weissman, Stanford University, "Biology of Stem and Progenitor Cells"
  • Dr. Mario R. Capecchi, University of Utah, "Modification of Our Genome in the 21st Century"

2002 (30th Lectures)

  • Dr. Thomas A. Steitz, Yale University, "The Machines of Gene Expression: From DNA to Protein"
  • Dr. William J. Rutter, University of California, San Francisco, "The New Role of Technology Companies in Generating Scientific Information and in Economic and Social Development"

2001 (29th Lectures)

  • Dr. Elizabeth H. Blackburn, University of California, San Francisco, "Telomeres, Telomerase, and Their Cellular Growth Effects"
  • Dr. Robert A. Weinberg, Massachusetts Institute of Technology, "How Human Cancer Cells Arise"

2000 (28th Lectures)

  • Dr. H. Robert Horvitz, MIT, "Genetic Control of Programmed Cell Death in C. elegans"
  • Dr. John D. Gearhart, "Human Embryonic Stem Cells: Promises and Problems"

1999 (27th Lectures)

  • Dr. Jeffrey M. Friedman, Rockfeller University, "Leptin and the Neural Circuit Regulating Body Weight"
  • Dr. Richard A. Lerner, Scripps Research Institute, "Using Reactive Immunization to Produce Antibody Aldolases of Remarkable Efficiency and Scope"

1998 (26th Lectures)

  • Dr. Matthew P. Scott, Stanford University, "Hedgehog/Patched Signaling in Animal Development and Disease"
  • Dr. John B. Gurdon, University of Cambridge, England, "Redirection of Cell Fate: From Clones to Signals"

1997 (25th Lectures)

  • Dr. Leland H. Hartwell, Fred Hutchinson Cancer Research Center, "Yeast and Cancer"
  • Dr. Martin Rodbell, National Institute of Environmental Health Sciences, "Signal Transduction: A Biological Web"

1996 (24th Lectures)

  • Dr. Richard Axel, Columbia University, "The Molecular Biology of Smell"
  • Dr. Harold E. Varmus, National Institutes of Health, "Budgets and Biology"

1995 (23rd Lectures)

  • Dr. Solomon H. Snyder, The Johns Hopkins University School of Medicine, "Novel Messengers in the Brain"
  • Dr. Bruce M. Alberts, National Academy of Sciences, "Science Education as a Centerpiece for Educational Reform: Important Roles for Both Scientists and Outstanding Science Teachers"

1994 (22nd Lectures)

  • Dr. Christine Nüsslein-Volhard, Max-Planck Institute, "Pattern Formation in Flies and Fish"
  • Dr. Howard K. Schachman, University of California, Berkeley, "Maintaining Integrity in Science Requires Vigilance Not Vigilantes"

1993 (21st Lectures)

  • Dr. Marc W. Kirschner, University of California, "Biochemical Transitions in the Cell Cycle"
  • Dr. Phillip A. Sharp, Massachusetts Institute of Technology, "RNA Splicing and Biotechnology"

1992 (20th Lectures)

  • Dr. Paul Nurse, Oxford University, "Eukaryotic Cell Cycle Control"
  • Dr. Etienne Emile Baulieu, Université Paris-Sud, "RU486: From Molecular Endocrinology to Fertility Control"

1991 (19th Lectures)

  • Dr. Joseph L. Goldstein, University of Texas Southwestern Medical Center, "The Mevalonate Pathway: Link Between Cholesterol Metabolism and Cell Growth"
  • Dr. Michael S. Brown, University of Texas Southwestern Medical Center, "Atherosclerosis: A Rational Approach"

1990 (18th Lectures)

  • Dr. Harold M. Weintraub, Fred Hutchinson Cancer Research Center, "MyoD--A Master Regulatory Gene for Myogenesis"
  • Dr. Max F. Perutz, MRC Laboratory of Molecular Biology, "Determining the Atomic Structure of Living Matter: What Use to Medicine?"