Baylor College of Medicine

Treatment Resistant Depression: Augmentation Versus Switch (H-40432)



Augmentation versus Switch: Comparative Effectiveness Research Trial for Non-Responders with Treatment Resistant Depression

Purpose of Study
The purpose of this study is to compare the effectiveness of three open label treatments in patients suffering from treatment resistant depression.

Baylor College of Medicine and Michael E. DeBakey VA Medical Center are conducting a clinical trial to study the comparative effectiveness of three FDA-approved noninvasive treatment strategies for individuals suffering from treatment resistant depression. Patients will receive either repetitive transcranial magnetic stimulation (rTMS) in conjunction with their current antidepressant medications or an alternative noninvasive treatment. The study is sponsored by the Patient-Centered Outcomes Research Institute (PCORI) and is being conducted at several sites nationwide.

Individuals between the ages of 18-80 and who have not responded to at least two antidepressant medications are eligible for screening. Compensation will be provided for time and travel.

To see if you qualify, please call (713) 689-9856 or email

All inquiries are confidential.


Additional Information


Repetitive transcranial magnetic stimulation (rTMS) is a form of brain stimulation therapy used to treat depression and anxiety. More information about rTMS as a treatment for depression can be found here:

IRB: H-40432




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