Gianfranco Spalletta, M.D.

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Gianfranco Spalletta, M.D.

Adjunct Associate Professor

Email

gianfranco.spalletta@bcm.edu

Positions

Adjunct Associate Professor: Menninger Department of Psychiatry and Behavioral Sciences
Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry
Baylor College of Medicine
Houston, Texas United States

Addresses

Medical Office Bldg-McNair (Office)
: Room: MMOB-E4.400
Houston, TX 77030
United States
gianfranco.spalletta@bcm.edu

IRCCS Santa Lucia Foundation - Neuropsychiatry Laboratory (Lab)
: Via Ardeatina, 306
Rome00179
United States
Phone: 390651501575
g.spalletta@hsantalucia.it
http://www.neuropsichiatrialab.com

Education

MD from Sapienza University: Rome, Italy Italy

Residency at Tor Vergata University: Rome, Italy; Psychiatry

PhD from Catholic University: Rome, Italy; Neuropsychology

Professional Interests

Neuropsychiatry of Alzheimer's disease and Mild Cognitive Impairment
Neuropsychiatry of Parkinson's disease
Neuropsychiatry of stroke
Cognitive deficits and associated brain structural abnormalities of schizophrenia
Mechanisms of brain aging and subclinical neuropsychiatry phenomenology in healthy people

Websites

VIICTR Publications List

Selected Publications

Di Paola M, Phillips O, Orfei MD, Piras F, Cacciari C, Caltagirone C, Spalletta G "Corpus Callosum Structure is Topographically Correlated with the Early Course of Cognition and Depression in Alzheimer's Disease." J Alzheimers Dis. 2015 Feb 3; Pubmed PMID: 25649657
Spalletta G, Piras F, Piras F, Sancesario G, Iorio M, Fratangeli C, Cacciari C, Caltagirone C, Orfei MD "Neuroanatomical correlates of awareness of illness in patients with amnestic mild cognitive impairment who will or will not convert to Alzheimer's disease." Cortex. 2014 Dec;61:183-195. Pubmed PMID: 25481475
Pontieri FE, Assogna F, Pellicano C, Cacciari C, Pannunzi S, Morrone A, Danese E, Caltagirone C, Spalletta G "Sociodemographic, neuropsychiatric and cognitive characteristics of pathological gambling and impulse control disorders NOS in Parkinson׳s disease." Eur Neuropsychopharmacol. 2015 Jan;25(1):69-76. Pubmed PMID: 25435085
Chiapponi C, Piras F, Fagioli S, Girardi P, Caltagirone C, Spalletta G "Hippocampus age-related microstructural changes in schizophrenia: a case-control mean diffusivity study." Schizophr Res. 2014 Aug;157(1):214-217. Pubmed PMID: 24924408

Dahm L, Ott C, Steiner J, Stepniak B, Teegen B, Saschenbrecker S, Hammer C, Borowski K, Begemann M, Lemke S, Rentzsch K, Probst C, Martens H, Wienands J, Spalletta G, Weissenborn K, Stöcker W, Ehrenreich H "Seroprevalence of autoantibodies against brain antigens in health and disease." Ann Neurol. 2014 Jul;76(1):82-94. Pubmed PMID: 24853231
Spalletta G, Piras F, Piras F, Caltagirone C, Orfei MD "The structural neuroanatomy of metacognitive insight in schizophrenia and its psychopathological and neuropsychological correlates." Hum Brain Mapp. 2014 Sep;35(9):4729-4740. Pubmed PMID: 24700789
Spalletta G, Robinson RG, Cravello L, Pontieri FE, Pierantozzi M, Stefani A, Long JD, Caltagirone C, Assogna F "The early course of affective and cognitive symptoms in de novo patients with Parkinson's disease." J Neurol. 2014 Jun;261(6):1126-1132. Pubmed PMID: 24695996
Sannino S, Gozzi A, Cerasa A, Piras F, Scheggia D, Managò F, Damiano M, Galbusera A, Erickson LC, De Pietri Tonelli D, Bifone A, Tsaftaris SA, Caltagirone C, Weinberger DR, Spalletta G, Papaleo F "COMT Genetic Reduction Produces Sexually Divergent Effects on Cortical Anatomy and Working Memory in Mice and Humans." Cereb Cortex. 2014 Mar 21; Pubmed PMID: 24658585
Spalletta G, Caltagirone C, Padovani A, Sorbi S, Attar M, Colombo D, Cravello L; E V O L U T I O N study Working Group "Cognitive and affective changes in mild to moderate Alzheimer's disease patients undergoing switch of cholinesterase inhibitors: a 6-month observational study." PLoS One. 2014 Feb 19;9(2):e89216. Pubmed PMID: 24586603
Papiol S, Mitjans M, Assogna F, Piras F, Hammer C, Caltagirone C, Arias B, Ehrenreich H, Spalletta G "Polygenic determinants of white matter volume derived from GWAS lack reproducibility in a replicate sample. Transl Psychiatry." Transl Psychiatry. 2014 Feb 18;4:e362. Pubmed PMID: 24548877
Spalletta G, Cravello L, Imperiale F, Salani F, Bossù P, Picchetto L, Cao M, Rasura M, Pazzelli F, Orzi F, Caltagirone C, Robinson RG, Cacciari C "Neuropsychiatric symptoms and interleukin-6 serum levels in acute stroke." J Neuropsychiatry Clin Neurosci. 2013;25(4):255-263. Pubmed PMID: 24247852
Piras F, Piras F, Caltagirone C, Spalletta G "Brain circuitries of obsessive compulsive disorder: a systematic review and meta-analysis of diffusion tensor imaging studies." Neurosci Biobehav Rev. 2013 Dec;37(10):2856-2877. Pubmed PMID: 24177038
Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Mohd Jofrry S, Gurvich A, Jensen N, Ostmeier K, Lühder F, Probst C, Martens H, Gillis M, Saher G, Assogna F, Spalletta G, Stöcker W, Schulz TF, et al "Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity." Mol Psychiatry. 2014 Oct;19(10):1143-1149. Pubmed PMID: 23999527
Spalletta G, Piras F, Caltagirone C, Fagioli S "Hippocampal multimodal structural changes and subclinical depression in healthy individuals." J Affect Disord. 2014 Jan;152:105-112. Pubmed PMID: 23800444
Spalletta G, Fagioli S, Meco G, Pierantozzi M, Stefani A, Pisani V, Caltagirone C, Pontieri FE, Assogna F "Hedonic tone and its mood and cognitive correlates in Parkinson's disease." Depress Anxiety. 2013 Jan;30(1):85-91. Pubmed PMID: 23300113
Laricchiuta D, Petrosini L, Piras F, Macci E, Cutuli D, Chiapponi C, Cerasa A, Picerni E, Caltagirone C, Girardi P, Tamorri SM, Spalletta G "Linking novelty seeking and harm avoidance personality traits to cerebellar volumes." Hum Brain Mapp. 2014 Jan;35(1):285-296. Pubmed PMID: 22965823
Carlesimo GA, Piras F, Assogna F, Pontieri FE, Caltagirone C, Spalletta G "Hippocampal abnormalities and memory deficits in Parkinson disease: a multimodal imaging study." Neurology. 2012 Jun 12;78(24):1934-1945. Pubmed PMID: 22649213
Orfei MD, Piras F, Macci E, Caltagirone C, Spalletta G "The neuroanatomical correlates of cognitive insight in schizophrenia." Soc Cogn Affect Neurosci. 2013 Apr;8(4):418-423. Pubmed PMID: 22287264
Assogna F, Palmer K, Pontieri FE, Pierantozzi M, Stefani A, Gianni W, Caltagirone C, Spalletta G "Alexithymia is a non-motor symptom of Parkinson disease." Am J Geriatr Psychiatry. 2012 Feb;20(2):133-141. Pubmed PMID: 22273734
Assogna F, Cravello L, Caltagirone C, Spalletta G "Anhedonia in Parkinson's disease: a systematic review of the literature." Mov Disord. 2011 Aug 15;26(10):1825-1834. Pubmed PMID: 21661052
Adriano F, Caltagirone C, Spalletta G "Hippocampal volume reduction in first-episode and chronic schizophrenia: a review and meta-analysis." Neuroscientist. 2012 Apr;18(2):180-200. Pubmed PMID: 21531988
Donohoe G, Rose E, Frodl T, Morris D, Spoletini I, Adriano F, Bernardini S, Caltagirone C, Bossù P, Gill M, Corvin AP, Spalletta G "ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia." Neuroimage. 2011 Feb 1;54(3):2132-2137. Pubmed PMID: 20934520
Spoletini I, Piras F, Fagioli S, Rubino IA, Martinotti G, Siracusano A, Caltagirone C, Spalletta G "Suicidal attempts and increased right amygdala volume in schizophrenia." Schizophr Res. 2011 Jan;125(1):30-40. Pubmed PMID: 20869847
Piras F, Caltagirone C, Spalletta G "Working memory performance and thalamus microstructure in healthy subjects." Neuroscience. 2010 Dec 1;171(2):496-505. Pubmed PMID: 20850507
Orfei MD, Varsi AE, Blundo C, Celia E, Casini AR, Caltagirone C, Spalletta G "Anosognosia in mild cognitive impairment and mild Alzheimer's disease: frequency and neuropsychological correlates." Am J Geriatr Psychiatry. 2010 Dec;18(12):1133-1140. Pubmed PMID: 20808100
Spalletta G, Musicco M, Padovani A, Rozzini L, Perri R, Fadda L, Canonico V, Trequattrini A, Pettenati C, Caltagirone C, Palmer K "Neuropsychiatric symptoms and syndromes in a large cohort of newly diagnosed, untreated patients with Alzheimer disease." Am J Geriatr Psychiatry. 2010 Nov;18(11):1026-1035. Pubmed PMID: 20808086
De Gennaro L, Cipolli C, Cherubini A, Assogna F, Cacciari C, Marzano C, Curcio G, Ferrara M, Caltagirone C, Spalletta G "Amygdala and hippocampus volumetry and diffusivity in relation to dreaming." Hum Brain Mapp. 2011 Sep;32(9):1458-1470. Pubmed PMID: 20740648
éran P, Cherubini A, Assogna F, Piras F, Quattrocchi C, Peppe A, Celsis P, Rascol O, Démonet JF, Stefani A, Pierantozzi M, Pontieri FE, Caltagirone C, Spalletta G, Sabatini U "Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature." Brain. 2010 Nov;133(11):3423-3433. Pubmed PMID: 20736190
Adriano F, Spoletini I, Caltagirone C, Spalletta G "Updated meta-analyses reveal thalamus volume reduction in patients with first-episode and chronic schizophrenia." Schizophr Res. 2010 Oct;123(1):1-14. Pubmed PMID: 20682456
Robinson RG, Spalletta G "Poststroke depression: a review." Can J Psychiatry. 2010 Jun;55(6):341-349. Pubmed PMID: 20540828
Di Paola M, Di Iulio F, Cherubini A, Blundo C, Casini AR, Sancesario G, Passafiume D, Caltagirone C, Spalletta G "When, where, and how the corpus callosum changes in MCI and AD: a multimodal MRI study." Neurology. 2010 Apr 6;74(14):1136-1142. Pubmed PMID: 20368633
Di Iulio F, Palmer K, Blundo C, Casini AR, Gianni W, Caltagirone C, Spalletta G "Occurrence of neuropsychiatric symptoms and psychiatric disorders in mild Alzheimer's disease and mild cognitive impairment subtypes." Int Psychogeriatr. 2010 Jun;22(4):629-640. Pubmed PMID: 20367890
Piras F, Cherubini A, Caltagirone C, Spalletta G "Education mediates microstructural changes in bilateral hippocampus." Hum Brain Mapp. 2011 Feb;32(2):282-289. Pubmed PMID: 20336658
Cherubini A, Péran P, Spoletini I, Di Paola M, Di Iulio F, Hagberg GE, Sancesario G, Gianni W, Bossù P, Caltagirone C, Sabatini U, Spalletta G "Combined volumetry and DTI in subcortical structures of mild cognitive impairment and Alzheimer's disease patients." J Alzheimers Dis. 2010;19(4):1273-1282. Pubmed PMID: 20308792
Palmer K, Di Iulio F, Varsi AE, Gianni W, Sancesario G, Caltagirone C, Spalletta G "Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer's disease: the role of depression and apathy." J Alzheimers Dis. 2010;20(1):175-183. Pubmed PMID: 20164594
Carlesimo GA, Cherubini A, Caltagirone C, Spalletta G "Hippocampal mean diffusivity and memory in healthy elderly individuals: a cross-sectional study." Neurology. 2010 Jan 19;74(3):194-200. Pubmed PMID: 20054010
Donohoe G, Frodl T, Morris D, Spoletini I, Cannon DM, Cherubini A, Caltagirone C, Bossù P, McDonald C, Gill M, Corvin AP, Spalletta G "Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia." Neuropsychopharmacology. 2010 Jan;35(2):368-373. Pubmed PMID: 19794403
Di Paola M, Luders E, Di Iulio F, Cherubini A, Passafiume D, Thompson PM, Caltagirone C, Toga AW, Spalletta G "Callosal atrophy in mild cognitive impairment and Alzheimer's disease: different effects in different stages." Neuroimage. 2010 Jan 1;49(1):141-149. Pubmed PMID: 19643188
Spoletini I, Cherubini A, Banfi G, Rubino IA, Peran P, Caltagirone C, Spalletta G "Hippocampi, thalami, and accumbens microstructural damage in schizophrenia: a volumetry, diffusivity, and neuropsychological study." Schizophr Bull. 2011 Jan;37(1):118-130. Pubmed PMID: 19542526
Cherubini A, Spoletini I, Péran P, Luccichenti G, Di Paola M, Sancesario G, Gianni W, Giubilei F, Bossù P, Sabatini U, Caltagirone C, Spalletta G "A multimodal MRI investigation of the subventricular zone in mild cognitive impairment and Alzheimer's disease patients." Neurosci Lett. 2010 Jan 22;469(2):214-218. Pubmed PMID: 19962428