Melina A Agosto, Ph.D.
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Melina A Agosto, Ph.D.
Assistant Professor
Positions
- Assistant Professor
-
Biochemistry
Baylor College of Medicine
Houston, Texas United States
Addresses
- Baylor College of Medicine (Lab)
-
BCM-Alkek Graduate School
Houston, TX 77030
United States
Education
- BS from Massachusetts Institute of Technology
- 06/2000 - Cambridge, Massachusetts United States
- Materials Science and Engineering
- BS from Massachusetts Institute of Technology
- 02/2001 - Cambridge, Massachusetts United States
- Biology
- PhD from Harvard University
- 03/2008 - Boston, Massachusetts United States
- Microbiology and Molecular Genetics
- Post-Doctoral Fellowship at Children's Hospital
- 10/2008 - Boston, Massachusetts United States
- Biochemistry
- Post-Doctoral Fellowship at Baylor College of Medicine
- Houston, Texas United States
- Biochemistry and Molecular Biology
Honors & Awards
- Knights Templar Pediatric Ophthalmology Career-Starter Grant
- 01/2012
Professional Interests
- Cryo-Electron Microscopy and Tomography
- Membrane Proteins
- Neural Plasticity and Degeneration
- Signal Transduction
- Structural Biology and Macromolecular Assemblies
- Retina
Websites
Selected Publications
- Agosto MA, Ivanovic T, Nibert ML "Mammalian reovirus, a nonfusogenic nonenveloped virus, forms size-selective pores in a model membrane." Proc Natl Acad Sci. 2006 Oct 31;103(44):16496-501. Pubmed PMID: 17053074
- Agosto MA, Middleton JK, Freimont EC, Yin J, Nibert ML "Thermolabilizing pseudoreversions in reovirus outer-capsid protein μ1 rescue the entry defect conferred by a thermostabilizing mutation." J Virol. 2007 Jul;81(14):7400-7409. Pubmed PMID: 17507494
- Agosto MA, Myers KS, Ivanovic T, Nibert ML "A positive-feedback mechanism promotes reovirus particle conversion to the intermediate associated with membrane penetration." Natl Acad Sci. 2008 Jul 29;105(30):10571-6. Pubmed PMID: 18653761
- Agosto MA, Zhang Z, He F, Anastassov IA, Wright SJ, McGehee J, Wensel TG "Oligomeric State of Purified TRPM1, a Protein Essential for Dim Light Vision." J Biol Chem. 2014 Sep 26;289(39):27019-33. Pubmed PMID: 25112866
- Zhang Z, He F, Constantine R, Baker ML, Baehr W, Schmid MF, Wensel TG, Agosto MA "Domain organization and conformational plasticity of the G protein effector, PDE6." J Biol Chem. 2015;290:12833-12843. Pubmed PMID: 25809480
- Agosto MA, Anastassov IA, Robichaux MA, Wensel TG "A large endoplasmic reticulum-resident pool of TRPM1 in retinal ON bipolar cells." eNeuro. 2018;5:ENEURO.0143-18.2018. Pubmed PMID: 30027108
- Agosto MA, Anastassov IA, Wensel TG "Differential epitope masking reveals synapse-specific complexes of TRPM1." Vis Neurosci. 2018;35:e001. Pubmed PMID: 29370879
- He F, Agosto MA, Anastassov IA, Tse DY, Wu SM, Wensel TG "Phosphatidylinositol-3-phosphate is light-regulated and essential for survival in retinal rods." Sci Rep. 2016;6:26978. Pubmed PMID: 27245220
- He F, Nichols RM, Kailasam L, Wensel TG, Agosto MA "Critical role for phosphatidylinositol-3 kinase Vps34/PIK3C3 in ON-bipolar cells." Invest Ophthalmol Vis Sci. 2019;60:2861-2874. Pubmed PMID: 31260037
- Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ "The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration." PLoS Biol.. 2014;12:e1001847.
- Agosto MA, Wensel TG "LRRTM4 is a member of the trans-synaptic complex between rod photoreceptors and ON bipolar cells." J Comp Neurol. 2020; Pubmed PMID: 32390181
Memberships
- Association for Research in Vision and Ophthalmology
- Member (01/2011)
- Sigma Xi
- Member (01/1999)
Funding
- Identification and Characterization of TRPM1 Interaction Partners in the Retina (07/01/2012 - 06/30/2013) Grant funding from Pediatric Ophthalmology Career-Starter Grant
- The role of transient receptor potential channel TRPM1 in vertebrate vision Postdoctoral Ruth L. Kirschstein National Research Service Award - #F32 EY200672 (12/01/2009 - 11/30/2011) Grant funding from NIH/NEI
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