Positions
- Professor
-
Pharmacology and Chemical Biology
Baylor College of Medicine
Houston, TX US
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Education
- Ph.D. from University Of Toronto
- 01/1978 - Toronto, Canada
- M.Phil. from Chinese University Of Hong Kong
- 01/1973 - Hong Kong, Hong Kong
- BSc from Chinese University Of Hong Kong
- 01/1971 - Hong Kong, Hong Kong
Professional Statement
Identification and purification of Anti-tumor agents from Chinese medicine. Herbal Medicine has been a common therapeutic approach for various illnesses, including cancerous tumors, for centuries. It was found that the extract from the husk of a plant (Xanthoceras sorbifolia Bunge (Sapindaceae)) contain saponins that have anti-tumor effect. The active compound was purified and modified. In vitro studies with the compound show that it inhibits cancer cells’ growth. Application of this drug and the structure/function relationship is the focus of current research. The goal of this project is to identify the cellular target site and to understand the drug mechanism.Websites
Selected Publications
- Chan PK, Chan FY "A study of correlation between NPM-translocation and apoptosis in cells induced by daunomycin.." Biochem. Pharmacol.. 1999 Jun 1;57(11):1265-73. Pubmed PMID: 10230770
- Chan PK "Acylation with diangeloyl groups at C21-22 positions in triterpenoid saponins is essential for cytotoxicity towards tumor cells.." Biochem. Pharmacol.. 2007 Feb 1;73(3):341-50. Pubmed PMID: 17092489
- Chan PK "Characterization and cellular localization of nucleophosmin/B23 in HeLa cells treated with selected cytotoxic agents (studies of B23-translocation mechanism).." Exp. Cell Res.. 1992 Nov;203(1):174-81. Pubmed PMID: 1426041
- Chan PK "Cross-linkage of nucleophosmin in tumor cells by nitrogen mustard.." Cancer Res.. 1989 Jun 15;49(12):3271-5. Pubmed PMID: 2720680
- Chan PK, Zhao M, Che CT, Mak E "Cytotoxic acylated triterpene saponins from the husks of Xanthoceras sorbifolia.." J. Nat. Prod.. 2008 Jul;71(7):1247-50. Pubmed PMID: 18549275
- Liu QR, Chan PK "Formation of nucleophosmin/B23 oligomers requires both the amino- and the carboxyl-terminal domains of the protein.." Eur. J. Biochem.. 1991 Sep 15;200(3):715-21. Pubmed PMID: 1915343
- Liu QR, Chan PK "Identification of a long stretch of homopurine.homopyrimidine sequence in a cluster of retroposons in the human genome.." J. Mol. Biol.. 1990 Apr 5;212(3):453-9. Pubmed PMID: 2157848
- Finch RA, Revankar GR, Chan PK "Nucleolar localization of nucleophosmin/B23 requires GTP.." J. Biol. Chem.. 1993 Mar 15;268(8):5823-7. Pubmed PMID: 8095498
- Chan PK, Chan FY "Nucleophosmin/B23 (NPM) oligomer is a major and stable entity in HeLa cells.." Biochim. Biophys. Acta. 1995 May 17;1262(1):37-42. Pubmed PMID: 7772597
- Finch RA, Revankar GR, Chan PK "Structural and functional relationships of toyocamycin on NPM-translocation.." Anticancer Drug Des.. 1997 Apr;12(3):205-15. Pubmed PMID: 9154111
- Chan PK, Bloom DA, Hoang TT "The N-terminal half of NPM dissociates from nucleoli of HeLa cells after anticancer drug treatments.." Biochem. Biophys. Res. Commun.. 1999 Oct 14;264(1):305-9. Pubmed PMID: 10527882
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