Email

jihyey@bcm.edu

Positions

Assistant Professor

Molecular and Human Genetics
Baylor College of Medicine (BCM)
Houston, TX US

Assistant Professor

USDA/ARS Children's Nutrition Research Center

Member

Dan L Duncan Comprehensive Cancer Center (BCM)
Houston, TX United States

Member

Texas Medical Center (TMC)
Digestive Disease Center (DDC)
Houston, TX

Member

The Alkek Center for Metagenomics and Microbiome Research (BCM)
Houston, TX

Faculty Member

Chemical, Physical & Structural Biology Graduate Program

Faculty Member

Cancer & Cell Biology Graduate Program

Faculty Member

Genetics & Genomics Graduate Program

CPRIT Scholar in Cancer Research

Baylor College of Medicine

Pew-Stewart Scholar for Cancer Research

Baylor College of Medicine

Education

Postdoctoral Fellowship at Weill Cornell Medicine

New York, New York United States

PhD from Johns Hopkins University, School of Medicine

Baltimore, Maryland United States

MS from Korea Advanced Institute of Science and Technology (KAIST)

Daejoen, South Korea

BA from Sogang University

Seoul, South Korea

Professional Interests

• Understanding the role of dietary factors in colorectal cancer pathogenesis (Key words: Cancer Metabolism, Microbiome, Genetic mutations, Mouse models, Organoids)

Professional Statement

Colorectal cancer is the second leading cause of cancer-related deaths in developed countries. Epidemiological studies strongly suggest that diet is the most important environmental factor in colorectal cancer development. Indeed, diet is known to affect many important aspects of cancer development such as epigenetics, metabolism, immune systems and gut microbiota. As such, if we can identify and understand the mechanisms by which dietary factors can prevent or facilitate cancer development, we will be able to control cancer initiation, progression and metastasis more effectively. Unfortunately, the field connecting diet to cancer has been difficult to study experimentally in humans. The main challenge is the difficulty to perfectly control or restrict an individual’s diet or lifestyle, which can confound the dietary factors in question. Furthermore, it is difficult to dissect the molecular mechanisms of the complex relationship between diet and pathogenesis of cancer in human subjects.

The goal of our laboratory is to identify dietary factors that can affect tumorigenesis and understand the molecular basis for the relationship between diet and colorectal cancer using preclinical model systems. In this regard, we will use genetically engineered mouse models of intestinal cancer, ex vivo intestinal organoid co-culture systems and patient or mouse-derived organoid transplantation models. Furthermore, we have the integrative and systematic ‘-omics’ approaches using state-of-the-art techniques such as metabolomics and next-generation sequencing to untangle the complex but important relationship between dietary factors, genetics and cancer pathogenesis. Ultimately, our laboratory seeks to develop and discover novel strategies to prevent and treat colorectal cancer as well as other types of cancer by understanding the role of diet in cancer, which we believe can have a positive impact on society directly and immediately.

Websites

Selected Publications

• Ngo B, Van Riper JM, Cantley LC, Yun J "Targeting cancer vulnerabilities with high-dose vitamin C." Nat Rev Cancer. 2019;19:271-282. Pubmed PMID: 30967651
• Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio IIC, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SG, Cantley LC "Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH." Science. 2016 Pubmed PMID: 26541605
• Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Willson JK, Markowitz S, Zhou S, Diaz LA Jr, Velculescu VE, Lengauer C, Kinzler KW, Vogelstein B, Papadopoulos N "Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells." Science. 2009 Pubmed PMID: 19661383
• Gonclaves MD, Lu C, Tutnauer J, Hartman TE, Hwang S, Murphy CJ, Pauli C, Morris R, Taylor S, Bosch K, Yang S, Wang Y, Riper J, Lekaye HC, Roper J, Kim Y, Chen Q, Gross SS, Rhee KY, Cantley LC*, and Yun J* "High-fructose corn syrup enhances intestinal tumor growth in mice." Science. 2019 Pubmed PMID: 30898933

Memberships

Gulf Coast Center for Precision Environmental Health (GC-CPEH)

Member (01/2020)

Funding

CPRIT Scholar

Cancer Prevention Research Institute of Texas (CPRIT)

Career Transition Award (K22)

National Cancer Institute

V Scholar Award for Cancer Research

V Foundation

Pew-Steward Scholar for Cancer Research

Pew Foundation