Email

lingappa@bcm.edu

Positions

Associate Professor

Pediatrics-Newborn
Baylor College of Medicine
Houston, TX US

Addresses

Neonatology (Office)

Texas Children's Hospital - Feigin Center
1102 Bates Ave
Houston, TX 77030
United States
Phone: (832) 824-3208
lingappa@bcm.edu
BCM Neonatology

Education

MBBS from Kilpauk Medical College

Chennai, India

Residency at Post Graduate Institute of Medical Education and Research

Chandigarh, India

Residency at Miami Children's Hospital

Miami, FL

Pediatrics

Residency at University Of Chicago

Chicago, IL United States

Fellowship at Baylor College Of Medicine

Houston, TX United States

MS from Baylor College of Medicine

Houston, Texas United States

PhD from Baylor College of Medicine

Houston, Texas United States

Certifications

Pediatrics

American Board of Pediatrics

Neonatal-Perinatal Medicine

American Board of Pediatrics

Honors & Awards

Southern Society of Pediatric Research (SSPR) Faculty Award for Research

2015 and 2016

Southern Society of Pediatric Research (SSPR) Young Investigator Award

2012

Woman of Excellence

Baylor College of Medicine

Norton Rose Fulbright Faculty Excellence Award for Teaching and Evaluation

Baylor College of Medicine

Young Investigator Award

Department of Pediatrics, Baylor College of Medicine

Professional Statement

I am currently Associate Professor (with tenure) of Pediatrics in the Division of Neonatology at Baylor College of Medicine. I have dedicated myself to neonatology as a researcher, educator and a clinician. I lead my own independent lab in the section of neonatology and am currently funded by the NIH. My unique niche is to elucidate the mechanisms sex-specific differences in neonatal hyperoxic lung injury with the goal to develop individualized therapeutic options to decrease morbidity in preterm babies. I also take particular interest in evidence-based medicine (EBM) and lead several EBM initiatives in the fellowship program and the Department of Pediatrics. I have been fortunate to have leadership experience at national and regional organizations. As the leader for several national-level groups, I have been able to create a unique niche for myself as a leader in the neonatology subspecialty with my involvement in the American Academy of Pediatrics (AAP), Section of neonatal-perinatal medicine (SONPM), NIH-funded lung basic-science research, evidence-based clinical neonatology practice and trainee engagement and education.

Websites

Selected Publications

• Lingappan K, Srinivasan C, Jiang W, Wang L, Couroucli X, Moorthy B. "Analysis of the transcriptome in hyperoxic lung injury and sex-specific alterations in gene expression.." PLoS One.. 2014 Jul 8;9(7):e101581. Pubmed PMID: 25003466
• Lingappan K, Jiang W, Wang L, Wang G, Couroucli X, Shivanna B, Welty SE, Barrios R, Khan MF, Nebert DW, Roberts LJ, Moorthy B. "Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress.." Toxicol Sci.. 2014 Sep;141(1):68-77. Pubmed PMID: 24893714
• Lingappan K, Jiang W, Wang L, Moorthy B. "Sex-specific differences in neonatal hyperoxic lung injury.." Am J Physiol Lung Cell Mol Physiol.. 2016 Aug 1;311(2):L481-93. Pubmed PMID: 27343189

Memberships

American Academy of Pediatrics

American Thoracic Society

Funding

Mechanisms of sex specific differences in neonatal hyperoxic lung injury - #HL144775

$355,342.00 (07/01/2019 - 06/30/2024)

Grant funding from NIH/NHLBI

Bronchopulmonary dysplasia (BPD), a debilitating lung disease with long-term consequences, is the most common morbidity in extremely premature neonates. Male babies have a higher incidence of BPD compared to females. In this proposal, we will study how small RNAs lead to sex-specific differences in lung injury in repair. This will lead to the development of novel approaches and individualized therapeutic options for BPD.

Role of Growth Differentiation Factor 15 (GDF15) in alveolarization and pulmonary angiogenesis

American Lung Association

Leveraging multi-omics and advanced mouse models to delineate mechanisms underlying sex‐specific differences in recovery and repair after neonatal hyperoxia exposure in the developing lung - #HL146395

$240,000.00 (05/15/2020 - 04/30/2024)

Grant funding from NIH/NHLBI

Bronchopulmonary dysplasia (BPD), a debilitating lung disease with long-term consequences, is the most common morbidity in extremely premature neonates. Male babies have a higher incidence of BPD compared to females. In this proposal, we will study how lung injury and repair is different between male and female neonates and elucidate the molecular mechanisms modulating these sex-specific differences.

SEX AS BIOLOGICAL VARIABLE IN BRONCHOPULMONARY DYSPLASIA: ROLE OF THE NOTCH PATHWAY - #HD100862

$150,000.00 (06/23/2020 - 05/31/2022)

Grant funding from NIH/NICHD

In this proposal, we will study how the Notch pathway could lead to sex-specific differences in lung repair after exposure to hyperoxia. This will lead to the development of novel approaches and individualized therapeutic options for BPD.