Positions
- Assistant Professor
-
Neuroscience
Baylor College of Medicine
Houston, TX US
Addresses
- BCM-Smith Medical Research Bldg (Lab)
-
Room: BCMS-S607
Houston, TX 77030
United States
Education
- PhD from Nanjing Agricultural University
- 12/2006 - Nanjing, China
- Postdoctoral Fellowship at Institute of Neuroscience, Chinese Academy of Sciences
- 03/2009 - Shanghai, China
- Postdoctoral Fellowship at Vanderbilt University
- 07/2014 - Nashville, TN
Professional Interests
- Chronic pain, comorbidity of chronic pain and mood disorders, opioid analgesic tolerance and addiction.
Professional Statement
The primary research of my group is centered on synaptic and circuitry plasticity mechanisms underlying chronic pain, chronic pain-induced mood disorders, and opioid tolerance and translational studies in chronic pain management. We perform a multi-disciplinary approach to address these issues, including Patch-seq, mouse genetic tools, electrophysiology, behavioral assays, viral-mediated gene transfer, in vitro and in vivo imaging, molecular biology, and biochemistry. We are currently actively recruiting for a postdoctoral fellow, staff scientist, and research assistant with excellent skills/experience in one or more of the following areas: mouse behavior, rodent animal surgery, electrophysiology, imaging, biochemistry.Selected Publications
- Li L, Chen SR, Zhou MH, Wang L, Li DP, Chen H, Lee G, Jayaraman V, and Pan HL "α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly." Cell Rep.2021/July;36(3):109396.
- Chen J, Li L (co-first author), Chen SR, Chen H, Xie JD, Sirrieh RE, Maclean DM, Zhang Y, Jayaraman V, and Pan HL. "A novel α2δ-1-NMDA receptor coupling is critically involved in neuropathic pain and gabapentin action." Cell Rep.2018;22:2307-2321.
- Li L, Chen SR, Chen H, Wen L, Hittelman WN, Xie JD, Pan HL "Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain." Cell Rep.2016/May;15(7):1376-1383.
- Li L, Homan KT, Vishnivetskiy SA, Manglik A, Tesmer JJ, Gurevich VV, Gurevich EV "G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs)." J Bio Chem.2015/April;290(17):10775-90.
- Li L*, Liu S, Lei Y, Cheng Y, Yao C, Zhen X "Robo3.1A suppresses slit-mediated repulsion by triggering degradation of Robo2." J Neurosci Res. 2014 July ; 92(7) : 835-46.
- Li L, Cheng H, Gai J, Yu D "Genome-wide identification and characterization of putative cytochrome P450 genes in the model legume Medicago truncatula." Planta. 2007 June ; 226 (1) : 109-23.
- Li L, Wang X, Gai J, Yu D "Molecular cloning and characterization of a novel microsomal oleate desaturase gene from soybean." J Plant Physiol. 2007 November ; 164(11) : 1516-26.
Memberships
- Society of Neuroscience
- Gulf Coast Consortium for Translational Pain Research
- Therapeutic Innovation Center at BCM
Funding
- Synaptic structural and functional plasticity underlying transition to chronic pain
- $1,440,000.00 (09/01/2020 - 08/31/2024) Grant funding from DoD Chronic Pain Management Research Program
- Synaptic plasticity mechanism underlying the development of opioid analgesic tolerance and opioid-induced hyperalgesia (OIH)
- $200,000.00 (06/01/2020 - 05/31/2022) Grant funding from Mission Connect/TIRR Foundation (seed funding)
- Synaptic plasticity mechanisms underlying chronic pain-induced depression
- $60,000.00 (01/01/2021 - 12/31/2022) Grant funding from Mission Connect/TIRR Foundation (seed funding)
- Synaptic plasticity mechanisms underlying neuropathic pain following spinal cord injury
- $800,000.00 (09/01/2021 - 08/31/2024) Grant funding from DoD Spinal Cord Injury Research Program
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