Email

mullany@bcm.edu

Positions

Assistant Professor

Mol & Cell Biology-Mol.Regulation
Baylor College of Medicine

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Addresses

BCM-Alkek Building for Biomedical Research (Office)

Room: BCM-R412
Houston, TX 77030
United States
Phone: (713) 798-7882
mullany@bcm.edu

Education

PhD from University Of Minnesota

01/2004 - Minneapolis-St. Paul, Minnesota United States

MS from University Of Minnesota

01/1997 - Minneapolis-St. Paul, Minnesota United States

Honors & Awards

Identified as Promising Young Investigator featured in the 2014 edition of Molecular Endocrinology

Molecular Endocrinology

Professional Interests

• Cardiac reprogramming
• Transdifferentiation
• Fibrosis

Professional Statement

Dr. McClendon has a broad academic and research background in immunology, pathobiology, pharmacology, tumor biology, hormone signaling and metabolism. Her most significant early career contribution was the development of the first assay to measure of the affinity of an allergen-specific immune response.

Later studies were focused on interactions between steroid signaling and cell cycle control in liver, breast, prostate and ovarian cancers.

After joining Baylor College of Medicine, Dr. McClendon developed and characterized animal models of ovarian cancer that lead to important and novel findings that the tumor suppressor gene p53 promotes the ovarian cancer phenotype and steroid hormones estradiol and progesterone mediate metastasis of ovarian cancer cells. Follow-up studies identified that specific p53 mutations are associated with unique and common pathways that can be targeted for novel ovarian cancer therapies.

Dr. McClendon’s current research interests are to identify molecular and cellular signaling pathways involved in cardiac cellular reprogramming. This exciting new area of research is being explored as a promising approach to repair damaged heart tissue to improve the lives of patients with congestive heart failure. Dr. McClendon’s recent paper demonstrates a potent small molecule stimulator of steroid receptor coactivators improves cardiac function following myocardial infarction thus serving as an innovative agent for cardiac protection after ischemic injury.

Websites

Selected Publications

• Mullany LK, Nelsen CJ, Hanse EA, Goggin MM, Anttila CK, Peterson M, Bitterman PB, Raghavan A, Crary GS, Albrecht JH "Akt-mediated liver growth promotes induction of cyclin E through a novel translational mechanism and a p21-mediated cell cycle arrest.." J. Biol. Chem..2007/July20;282(29):21244-52. Pubmed PMID: 17517888
• Hanse EA, Nelsen CJ, Goggin MM, Anttila CK, Mullany LK, Berthet C, Kaldis P, Crary GS, Kuriyama R, Albrecht JH "Cdk2 plays a critical role in hepatocyte cell cycle progression and survival in the setting of cyclin D1 expression in vivo.." Cell Cycle.2009/September1;8(17):2802-9. Pubmed PMID: 19652536
• Fan HY, Liu Z, Mullany LK, Richards JS "Consequences of RAS and MAPK activation in the ovary: The good, the bad and the ugly.." Mol. Cell. Endocrinol..2012/June5;356(41276):74-9. Pubmed PMID: 22197887
• Hanse EA, Mashek DG, Becker JR, Solmonson AD, Mullany LK, Mashek MT, Towle HC, Chau AT, Albrecht JH "Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4a.." Cell Cycle.2012/July15;11(14):2681-90. Pubmed PMID: 22751438

Memberships

Beta, Beta, Beta Biological Honor Society

American Association for the Advancement of Sciences

American Society for Pharmacology and Experimental Therapeutics

Endocrine Society

Graduate Women in Science, Xi Chapter