Sangappa
Middle Name
B
Chadchan, M.Sc., Ph.D.
Middle Name
B
Picture
Sangappa
Middle Name
B
Chadchan, M.Sc., Ph.D.
Middle Name
B
Instructor
Positions
- Instructor
-
Pathology
Baylor College of Medicine
Houston, US
Addresses
- One Baylor Plaza (Office)
-
Houston, TX 77030
United States
Phone: (314) 583-7250
Sangappa.Chadchan@bcm.edu
- One Baylor Plaza (Lab)
-
Houston, TX 77030
United States
Phone: (314) 583-7250
Sangappa.Chadchan@bcm.edu
Education
- PhD from Jawaharlal Nehru University, New Delhi, India
- 03/2017 - New Delhi, New Delhi India
- MSc from Center for Advanced Life sciences, Deogiri College, Aurangabad
- 06/2010 - Aurangabad, Maharashtra India
- BSc from V.G. Shivdare College of Arts, Commerce & Sciences
- 06/2008 - Solapur, Maharashtra India
- Postdoctoral Fellowship at Washington University, School of Medicine in St. Louis
- 03/2022 - Saint Louis, Missouri United States
- Female Reproductive biology
Professional Statement
Highly motivated and goal-oriented research scientist in Female Reproductive Physiology & Pathology with more than 10 years of experience with a strong background in molecular and cellular biology. Skilled in a surgical model of Endometriosis, Embryo implantation, IVF, PCOS, etc. Strong research professional with a Doctor of Philosophy (Ph.D.) focused on the diagnostic or treatment strategy for female infertility diseases like Endometriosis, PCOS and Recurrent Pregnancy loss.Websites
Selected Publications
- Upendra Kumar Soni*, Sangappa B. Chadchan*, Vijay Kumar, Vaibhave Ubba, Mohammad Tariq Ali Khan, Budai Shanmukha Vivek Vinod, Rituraj Konwar, Himangsu Kousik Bora, Srikanta Kumar Rath, Sharad Sharma, Rajesh Kumar Jha "A high level of TGF-B1 promotes endometriosis development via cell migration, adhesiveness, colonization, and invasiveness." Biol Reprod..2019/April1;4:917–938. Pubmed PMID: 30423016
- Sangappa B Chadchan, Vineet K Maurya, Gwendalyn L Krekeler, Emily S Jungheim, Ramakrishna Kommagani "A Role for Malignant Brain Tumor Domain-Containing Protein 1 in Human Endometrial Stromal Cell Decidualization." Front Cell Dev Biol..2020/August11;8:745. Pubmed PMID: 32850854
- Sangappa B Chadchan, Meng Cheng, Lindsay A Parnell, Yin Yin, Andrew Schriefer, Indira U Mysorekar, Ramakrishna Kommagani "Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota." Hum Reprod..2019/June4;6:1106–1116. Pubmed PMID: 31037294
- Satish Agrawal, Monika Dwivedi, Hafsa Ahmad, Sangappa B. Chadchan, Abhishek Arya, Roshan Sikandar, Shweta Kaushik, Kalyan Mitra, Rajesh Kumar Jha, Anil Kumar Dwivedi "CD44 targeting hyaluronic acid coated lapatinib nanocrystals foster the efficacy against triple-negative breast cancer." Nanomedicine.2018/February14;(2):327-337. Pubmed PMID: 29129754
- Sangappa Basanna Chadchan, Vijay Kumar, Vineet Kumar Maurya, Upendra Kumar Soni, Rajesh Kumar Jha "Endoglin (CD105) coordinates the process of endometrial receptivity for embryo implantation." Mol Cell Endocrinol.. 2016 April 15; 425 : 69-83. Pubmed PMID: 26802878
- Vineet Kumar Maurya, Chadchan Sangappa, Vijay Kumar, Sahil Mahfooz, Archana Singh, Singh Rajender, Rajesh Kumar Jha "Expression and activity of Rac1 is negatively affected in the dehydroepiandrosterone induced polycystic ovary of mouse." J Ovarian Res.. 2014 March 14; : Pubmed PMID: 24628852
- Alison J Camden, Maria M Szwarc, Sangappa B Chadchan, Francesco J DeMayo, Bert W O'Malley, John P Lydon, Ramakrishna Kommagani "Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization." Mol Hum Reprod.. 2018 September 1; (9): 646–653. Pubmed PMID: 28911214
- Sangappa B Chadchan, Pooja Popli, Chandrasekhar R Ambati, Eric Tycksen, Sang Jun Han 3, Serdar E Bulu, Nagireddy Putluri, Scott W Biest, Ramakrishna Kommagani "Gut microbiota-derived short-chain fatty acids protect against the progression of endometriosis." LSA. 2021 September 30; 4 (12): Pubmed PMID: 34593556
- Stephanie A Michalski*, Sangappa B Chadchan*, Emily S Jungheim, Ramakrishna Kommagani "Isolation of Human Endometrial Stromal Cells for In Vitro Decidualization." J Vis Exp.. 2018 September 1; : Pubmed PMID: 30222162
- Raj Kumar Verma, Upendra Kumar Soni, Sangappa B. Chadchan, Vineet Kumar Maurya, Mohini Soni, Sudarsan Sarkar, J Venkatesh Pratap, Rajesh Kumar Jha "miR-149-PARP-2 Signaling Regulates E-cadherin and N-cadherin Expression in the Murine Model of Endometrium Receptivity." Reprod Sci.. 2022 March 29; : Pubmed PMID: 34460092
- Upendra Kumar Soni, Sangappa B. Chadchan, Rakesh Kumar Gupta, Vijay Kumar, Rajesh Kumar Jha "miRNA-149 targets PARP-2 in endometrial epithelial and stromal cells to regulate the trophoblast attachment process." 2021 May 29; gaab039 : Pubmed PMID: 34051087
- Anubha Joshi, Sahil Mahfooz , Vineet Kumar Maurya, Vijay Kumar, Sangappa B. Chadchan, Gurpreet Kaur, Kashif Hanif, Rajesh Kumar Jha "PARP1 during embryo implantation and its upregulation by oestradiol in mice." Reproduction. 2014 June 1; : Pubmed PMID: 24516177
- Upendra Kumar Soni*, Sangappa B. Chadchan*, Anubha Joshi, Vijay Kumar, Vineet Kumar Maurya, Raj Kumar Verma, Rajesh Kumar Jha "Poly(ADP-ribose) polymerase-2 is essential for endometrial receptivity and blastocyst implantation, and regulated by caspase-8." Mol Cell Endocrinol.. 2020 December 1; : Pubmed PMID: 32679243
- Vaibhave Ubba, Upendra Kumar Soni, Sangappa Chadchan, Vineet Kumar Maurya, Vijay Kumar, Ruchika Maurya, Himanshu Chaturvedi, Rajender Singh, Anila Dwivedi, Rajesh Kumar Jha "RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced Polycystic Ovary in Rat Model." Reprod Sci.. 2017 May 24; 24 (5): Pubmed PMID: 27662902
- Yan Yin, Meade E Haller, Sangappa B Chadchan, Ramakrishna Kommagani, Liang Ma "Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization." JCI Insight. 2021 September 8; : Pubmed PMID: 34292881
- Pooja Popli, Megan M Richters, Sangappa B Chadchan, Tae Hoon Kim, Eric Tycksen, Obi Griffith, Premal H Thaker, Malachi Griffith, Ramakrishna Kommagani "Splicing factor SF3B1 promotes endometrial cancer progression via regulating KSR2 RNA maturation." Cell Death Dis.. 2020 October 10; : Pubmed PMID: 33040078
- Arin K Oestreich, Sangappa B Chadchan, Pooja Popli, Alexandra Medvedev, Marina N Rowen, Claire S Stephens, Ran Xu, John P Lydon, Francesco J Demayo, Emily S Jungheim, Kelle H Moley, Ramakrishna Kommagani "The Autophagy Gene Atg16L1 is Necessary for Endometrial Decidualization." 2020 January 1; bqz039 : Pubmed PMID: 31875883
- Arin K Oestreich, Sangappa B Chadchan, Alexandra Medvedeva, John P Lydon, Emily S Jungheim, Kelle H Moley, Ramakrishna Kommagani "The autophagy protein, FIP200 (RB1CC1) mediates progesterone responses governing uterine receptivity and decidualization." Biol Reprod.. 2020 April 15; (4): 843–851. Pubmed PMID: 31901086
- Sangappa B Chadchan*, Pooja Popli*, Vineet K Maurya*, Ramakrishna Kommagani "The SARS-CoV-2 receptor, angiotensin-converting enzyme 2, is required for human endometrial stromal cell decidualization." Biol. Reprod.. 2021 February 11; 2 : Pages 336–343. Pubmed PMID: 33205194
- Vineet Kumar Maurya, Rajesh Kumar Jha, Vijay Kumar, Anubha Joshi, Sangappa B. Chadchan, Jasna Jagan Mohan, Malini Laloraya "Transforming growth factor-beta 1 (TGF-B1) liberation from its latent complex during embryo implantation and its regulation by estradiol in mouse." Biol Reprod.. 2013 October 10; 84 : 1-17. Pubmed PMID: 23926286
Memberships
- Society for the Study of Reproduction
- Trainee Member (01/2018 - 05/2022)
Skills
- Female Reproductive Physiology and Pathology
Languages
Hindi, Marathi, Kannada
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