Email

eric.vannostrand@bcm.edu

Positions

Assistant Professor

Biochemistry
Baylor College of Medicine

Education

PhD from Stanford University School of Medicine

09/2012 - Stanford, California United States

BS from Massachusetts Institute of Technology

06/2005 - Cambridge, Massachusetts United States

Postdoctoral Fellowship at University of California San Diego

03/2020 - La Jolla, California United States

Professional Interests

• RNA genomics technologies
• Mechanisms of RNA processing
• Host:RNA viral interactions
• Bioinformatics

Professional Statement

I am an Assistant Professor in the Department of Biochemistry and Molecular Biology, and member of the Therapeutic Innovation Center.

“I know that mutation of my RNA binding protein causes disease – but how do I know which of thousands of targets drive this phenotype?” The simplicity of this question belies the challenges involved in both identifying the direct and regulatory targets of the RNA binding protein (RBP), as well as narrowing the list of (often thousands or more) targets down to a set of phenotypically-relevant ones. My group uses a variety of genomics, molecular biology, and computational approaches to map and understand RNA processing regulatory networks, with the goals of uncovering new mechanisms in RNA processing and characterizing their roles in human physiology. We particularly focus on two biological systems: how RNA viruses hijack host RNA processing machineries to ensure proper replication and assembly, and how altered regulation of mRNA translation drives breast cancer.

Websites

Selected Publications

• Van Nostrand EL, Pratt GA, Yee BA, Wheeler EC, Blue SM, Mueller J, Park SS, Garcia KE, Gelboin-Burkhart C, Nguyen TB, Rabano I, Stanton R, Sundararaman B, Wang R, Fu XD, Graveley BR, Yeo GW "Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins." Genome Biology. 2020 Apr 6; Pubmed PMID: 32252787
• Van Nostrand EL*, Freese P*, Pratt GA*, Wang X*, Wei X*, Xiao R*, et al, Fu XD, Lécuyer E, Burge CB, Graveley BR, Yeo GW "A Large-Scale Binding and Functional Map of Human RNA Binding Proteins." Nature. 2020 Jul;583:711-719.
• Yee BA, Pratt GA, Graveley BR, Van Nostrand EL†, Yeo GW† "RBP-Maps enables robust generation of splicing regulatory maps." RNA. 2019 Feb; Pubmed PMID: 30413564
• Van Nostrand EL, Pratt GA, Shishkin AA, Gelboin-Burkhart C, Fang MY, Sundararaman B, Blue SM, Nguyen TB, Surka C, Elkins K, Stanton R, Rigo F, Guttman M, Yeo GW "Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)." Nature Methods. 2016 Jun; Pubmed PMID: 27018577