Email

gloria.echeverria@bcm.edu

Positions

Assistant Professor

Baylor College of Medicine
Houston, Texas US

CPRIT Scholar in Cancer Research

Cancer Prevention and Research Institute of Texas (CPRIT)

Member

Lester and Sue Smith Breast Center

Member

Dan L. Duncan Cancer Center

Member

Department of Medicine

Member

Department of Molecular and Cellular Biology

Addresses

Office: R516 (Lab)

One Baylor Plaza
Houston, TX 77030
United States
gloria.echeverria@bcm.edu
Echeverria Lab website

Office: R516 (Office)

One Baylor Plaza
Houston, TX 77030
United States
gloria.echeverria@bcm.edu
Echeverria Lab website

Education

BS from Texas A&M University

05/2008 - College Station, Texas United States

PhD from Baylor College of Medicine

10/2013 - Houston, Texas United States

Postdoctoral Fellowship at The University of Texas MD Anderson Cancer Center

12/2019 - Houston, Texas United States

Professional Statement

The Echeverria laboratory studies the molecular evolution of triple negative breast cancer (TNBC) therapy resistance and metastasis. Cancers are ecosystems of diverse tumor and stroma cell subpopulations, each capable of contributing to tumor progression. While the existence of this complex intra-tumor heterogeneity has been well documented, its functional repercussions remain unclear. The focus of the lab is to delineate the metabolic and molecular evolution of TNBC using state-of-the art patient-derived xenograft mouse models and in vitro mouse- and patient-derived organoids. The lab utilizes functional genomics approaches, single-cell technologies, multiplexed tissue imaging, and metabolomics with the ultimate goal of combating tumor evolution to improve the lives of women living with TNBC.

Websites

Selected Publications

• Echeverria GV, Ge Z, Seth S, Zhang X, Jeter-Jones S, Zhou X, Cai S, Tu Y, McCoy A, et al. "Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state." Sci Transl Med. 2019 Pubmed PMID: 30996079
• Hsu T, Simon L, Heill N, Marcotte R, Sayad A, Bland C, Echeverria GV, et al. "The spliceosome is a therapeutic vulnerability in MYC-driven cancer.." Nature. 2015 Pubmed PMID: 26331541
• Powell E, Shao J, Yuan Y, Chen H, Cai S, Echeverria GV, et al. "p53 deficiency linked to BTG2 loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in PDX models of triple negative breast cancer.." Breast Cancer Res. 2016 Pubmed PMID: 26818199
• Werden SJ, Sphyris N, Sarkar TR, Paranjape AN, LaBaff AM, Tabue JH, Hollier BG, Ramirez-Pena EQ, Soundarajan R, den Hollander P, Powell E, Echeverria GV, et al. "Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth." Oncogene. 2016 Pubmed PMID: 27292262

Funding

First-Time Faculty Recruitment Award

Grant funding from CPRIT

K22 Career Transition Award

Grant funding from NCI

Early Career Investigator Grant

Grant funding from MetaVivor

Young Investigator Grant

Grant funding from Breast Cancer Alliance