Positions

Assistant Professor of Surgery

Surgery
Thoracic Surgery
Baylor College of Medicine
HOUSTON, Texas United States

Director

Systems Onco-Immunology Lab

Member

Dan L Duncan Comprehensive Cancer Center

Addresses

Laboratory (Lab)

Alkek Building for Biomedical Research
Houston, TX 77030
United States

Education

Research Fellowship at Systems Biology, UT MD Anderson Cancer Center

HOUSTON, Texas United States

Clinical Fellowship at Thoracic Surgery, Center for Lung Cancer, National Cancer Center

Goyang, Republic of Korea

PhD from Yonsei University College of Medicine

Seoul, Republic of Korea

Residency at Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine

Seoul, Republic of Korea

MD from Yonsei University College of Medicine

Seoul, Republic of Korea

Honors & Awards

Young Investigator Award

Geneva, Swiss

European Association of Cardio-Thoracic Surgery (EACTS) (10/2007)

President’s Award

ISMICS 2010, Berlin, Germany

International Society for Minimally Invasive Cardiothoracic Surgery (06/2010)

KSEA collaboration award

KSEA (11/2017)

KSEA collaboration award

KSEA (11/2018)

Science Advisory Board

the Mesothelioma Applied Research Foundation (02/2021 - 12/2023)

Michael E. DeBakey Faculty Research Award

BAYLOR COLLEGE OF MEDICINE (07/2021 - 06/2022)

Professional Interests

• Systems Immunology
• CyTOF (Time-Of-Flight Mass Cytometry)
• Imaging Mass Cytometry (IMC)
• Malignant pleural mesothelioma
• Lung cancer
• Thymic epithelial tumors
• Single-Cell Multi-Omics

Professional Statement

Dr. Lee has more than 10 years of experience in studying lung cancer and esophageal cancer as a thoracic surgeon, 3 years of research experience in the Department of Systems Biology at UT MD Anderson Cancer Center, and 4 years of immunology experience in the Michael E. DeBakey Department of Surgery at Baylor College of Medicine. He is particularly enthusiastic about “Systems Immunology” in the field of immuno-oncology with specific experience in comprehensively integrating high dimensional single cell time-of-flight mass cytometry (CyTOF), imaging mass cytometry (IMC), mass spectrometry, and next generation sequencing data. He has recently generated a comprehensive atlas of the immunologic cellular networks within human malignant pleural mesothelioma (MPM) using CyTOF. Dr. Lee has applied innovative immunoproteomic and immunogenomic approaches to this framework to understand mechanisms underlying clinical outcomes and response to immunotherapy in this disease. He continues to characterize and unravel the cellular immune network by analyzing human and mouse CyTOF and IMC data, and correlating immune composition with immunogenomic determinants in order to predict clinical prognosis and response to immune checkpoint inhibitors. He is also conducting systems immunologic analyses of a mouse model of cancer, which will provide a rationale for human studies along these lines and can shed light on the development of novel immunotherapeutic molecules targeting immunotherapy-resistant patients. His strongest expertise lies in clinical implication and resources of thoracic oncology as a bridging role for the translational research. Dr. Lee's overarching goals are to identify potential therapeutic targets and to develop strong prognostic or predictive determinants for management of thoracic cancer including lung cancer, esophageal cancer, thymic epithelial tumors, and MPM by applying “comprehensive and integrated systems immunology” approaches.

Websites

Selected Publications

• Jang HJ, Lee HS, Burt BM, Lee GK, Yoon KA, Park YY, Sohn BH, Kim SB, Kim MS, Lee JM, Joo J, Kim SC, Yun JS, Na KJ, Choi YL, Park JL, Kim SY, Lee YS, Han L, Liang H, Mak D, Burks JK, Zo JI, Sugarbaker DJ, Shim YM, Lee JS. "Integrated genomic analysis of recurrence-associated small non-coding RNAs in oesophageal cancer." Gut.2017/February;66(2):215-225. Pubmed PMID: 27507904
• Wang DH, Lee HS, Yoon D, Berry G, Wheeler TM, Sugarbaker DJ, Kheradmand F, Engleman E, Burt BM "Progression of EGFR-Mutant Lung Adenocarcinoma is Driven By Alveolar Macrophages.." Clin Cancer Res.2017/February;23(3):778-788. Pubmed PMID: 27496865
• Lee HS, Jang HJ, Shah R, Yoon D, Hamaji M, Wald O, Lee JS, Sugarbaker DJ, Burt BM "Genomic Analysis of Thymic Epithelial Tumors Identifies Novel Subtypes Associated with Distinct Clinical Features." Clin Cancer Res.2017/April11;: Pubmed PMID: 28400429
• Hyun-Sung Lee, Hee-Jin Jang, Jong Min Choi, Jun Zhang, Veronica Lenge de Rosen, Thomas M. Wheeler, Ju-Seog Lee, Thuydung Tu, Peter T. Jindra, Ronald H. Kerman, Sung Yun Jung, Farrah Kheradmand, David J. Sugarbaker, and Bryan M. Burt "Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma." Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma JCI Insight.2018/April5;:

Funding

Individual Investigator Research Awards 2020

(03/01/2020 - 02/28/2023) Grant funding from CPRIT

the Cancer Prevention and Research Institute of Texas

Mini-pilot grant from Proteomics Core

(02/01/2020 - 01/31/2021) Grant funding from CPRIT

Investigator-Initiated Sponsored Research

(06/01/2021 - 05/31/2024) Grant funding from Samyang Biopharm USA

Therapeutic targeting of MIC-NKG2D signal to overcome resistance to checkpoint immunotherapy

Faculty Research Grant

(07/01/2021 - 06/30/2022) Grant funding from BCM Michael E. DeBakey Department of Surgery