Hyun-Sung Lee, M.D., Ph.D.
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Hyun-Sung Lee, M.D., Ph.D.
Assistant Professor of Surgery
Positions
- Assistant Professor of Surgery
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Surgery
Thoracic Surgery
Baylor College of Medicine
HOUSTON, Texas United States
- Director
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Systems Onco-Immunology Lab
- Member
-
Dan L Duncan Comprehensive Cancer Center
Addresses
- Laboratory (Lab)
-
Alkek Building for Biomedical Research
Houston, TX 77030
United States
Education
- Research Fellowship at Systems Biology, UT MD Anderson Cancer Center
- HOUSTON, Texas United States
- Clinical Fellowship at Thoracic Surgery, Center for Lung Cancer, National Cancer Center
- Goyang, Republic of Korea
- PhD from Yonsei University College of Medicine
- Seoul, Republic of Korea
- Residency at Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine
- Seoul, Republic of Korea
- MD from Yonsei University College of Medicine
- Seoul, Republic of Korea
Honors & Awards
- Young Investigator Award
- Geneva, Swiss
- European Association of Cardio-Thoracic Surgery (EACTS) (10/2007)
- President’s Award
- ISMICS 2010, Berlin, Germany
- International Society for Minimally Invasive Cardiothoracic Surgery (06/2010)
- KSEA collaboration award
- KSEA (11/2017)
- KSEA collaboration award
- KSEA (11/2018)
- Science Advisory Board
- the Mesothelioma Applied Research Foundation (02/2021 - 12/2023)
- Michael E. DeBakey Faculty Research Award
- BAYLOR COLLEGE OF MEDICINE (07/2021 - 06/2022)
Professional Interests
- Systems Immunology
- CyTOF (Time-Of-Flight Mass Cytometry)
- Imaging Mass Cytometry (IMC)
- Malignant pleural mesothelioma
- Lung cancer
- Thymic epithelial tumors
- Single-Cell Multi-Omics
Professional Statement
Dr. Lee has more than 10 years of experience in studying lung cancer and esophageal cancer as a thoracic surgeon, 3 years of research experience in the Department of Systems Biology at UT MD Anderson Cancer Center, and 4 years of immunology experience in the Michael E. DeBakey Department of Surgery at Baylor College of Medicine. He is particularly enthusiastic about “Systems Immunology” in the field of immuno-oncology with specific experience in comprehensively integrating high dimensional single cell time-of-flight mass cytometry (CyTOF), imaging mass cytometry (IMC), mass spectrometry, and next generation sequencing data. He has recently generated a comprehensive atlas of the immunologic cellular networks within human malignant pleural mesothelioma (MPM) using CyTOF. Dr. Lee has applied innovative immunoproteomic and immunogenomic approaches to this framework to understand mechanisms underlying clinical outcomes and response to immunotherapy in this disease. He continues to characterize and unravel the cellular immune network by analyzing human and mouse CyTOF and IMC data, and correlating immune composition with immunogenomic determinants in order to predict clinical prognosis and response to immune checkpoint inhibitors. He is also conducting systems immunologic analyses of a mouse model of cancer, which will provide a rationale for human studies along these lines and can shed light on the development of novel immunotherapeutic molecules targeting immunotherapy-resistant patients. His strongest expertise lies in clinical implication and resources of thoracic oncology as a bridging role for the translational research. Dr. Lee's overarching goals are to identify potential therapeutic targets and to develop strong prognostic or predictive determinants for management of thoracic cancer including lung cancer, esophageal cancer, thymic epithelial tumors, and MPM by applying “comprehensive and integrated systems immunology” approaches.Websites
industry-sponsored research grant
Selected Publications
- Jang HJ, Lee HS, Burt BM, Lee GK, Yoon KA, Park YY, Sohn BH, Kim SB, Kim MS, Lee JM, Joo J, Kim SC, Yun JS, Na KJ, Choi YL, Park JL, Kim SY, Lee YS, Han L, Liang H, Mak D, Burks JK, Zo JI, Sugarbaker DJ, Shim YM, Lee JS. "Integrated genomic analysis of recurrence-associated small non-coding RNAs in oesophageal cancer." Gut.2017/February;66(2):215-225. Pubmed PMID: 27507904
- Wang DH, Lee HS, Yoon D, Berry G, Wheeler TM, Sugarbaker DJ, Kheradmand F, Engleman E, Burt BM "Progression of EGFR-Mutant Lung Adenocarcinoma is Driven By Alveolar Macrophages.." Clin Cancer Res.2017/February;23(3):778-788. Pubmed PMID: 27496865
- Lee HS, Jang HJ, Shah R, Yoon D, Hamaji M, Wald O, Lee JS, Sugarbaker DJ, Burt BM "Genomic Analysis of Thymic Epithelial Tumors Identifies Novel Subtypes Associated with Distinct Clinical Features." Clin Cancer Res.2017/April11;: Pubmed PMID: 28400429
- Hyun-Sung Lee, Hee-Jin Jang, Jong Min Choi, Jun Zhang, Veronica Lenge de Rosen, Thomas M. Wheeler, Ju-Seog Lee, Thuydung Tu, Peter T. Jindra, Ronald H. Kerman, Sung Yun Jung, Farrah Kheradmand, David J. Sugarbaker, and Bryan M. Burt "Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma." Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma JCI Insight.2018/April5;:
- Ahn JH, Lee HS, Lee JS, Lee YS, Park JL, Kim SY, Hwang JA, Kunkeaw N, Jung SY, Kim TJ, Lee KS, Jeon SH, Lee I, Johnson BH, Choi JH, Lee YS "nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer." Nat Commun. 2018 March 21; 9 : Pubmed PMID: 29563500
- Jang HJ, Lee HS, Ramos D, Park IK, Kang CH, Burt BM, Kim YT "Transcriptome-based Molecular Subtyping of Non-Small Cell Lung Cancer May Predict Response to Immune Checkpoint Inhibitors." J Thorac Cardiovasc Surg. 2020 April ; 159 (4): 1598-1610. Pubmed PMID: 31879171
- Burt BM, Lee HS, Lenge De Rosen V, Hamaji M, Groth SS, Wheeler TM, Sugarbaker DJ "Soluble Mesothelin-Related Peptides to Monitor Recurrence After Resection of Pleural Mesothelioma." Ann Thorac Surg. 2017 November ; 104(5) : 1679-1687. Pubmed PMID: 28964420
- Burt BM, Lee HS, Raghuram AC, Strange C, Mason J, Strange T, Delgado J, Sugarbaker DJ "Preoperative Prediction of Unresectability in Malignant Pleural Mesothelioma." Ann Thorac Surg. 2020 June ; 159 (6): 2512-2520. Pubmed PMID: 32087959
- Lee HS, Jang HJ, Lo EM, Truong CY, Groth SS, Friedberg JS, Sugarbaker DJ, Burt BM "Povidone-iodine results in rapid killing of thymic epithelial tumour cells through cellular fixation." Interact Cardiovasc Thorac Surg. 2019 March 1; 28 (3): 353-359. Pubmed PMID: 30165653
- Im WR, Lee HS, Lee YS, Lee JS, Jang HJ, Kim SY, Park JL, Lee Y, Kim MS, Lee JM, Kim IH, Jeon SH, Lee YS "A Regulatory Noncoding RNA, nc886, Suppresses Esophageal Cancer by Inhibiting the AKT Pathway and Cell Cycle Progression." Cells. 2020 March 26; 9 (4): 801. Pubmed PMID: 32225025
- Lee HS, Hamaji M, Palivela N, Jang HJ, Splawn T, Ramos D, Lee AK, Raghuram AC, Ramineni M, Amos CI, Ripley RT, Burt BM "Prognostic Role of Programmed Cell Death 1 Ligand 1 (PD-L1) in Resectable Pleural Mesothelioma." Ann Thorac Surg. 2020 November 26; : Pubmed PMID: 33248997
- Jang HJ, Truong CY, Lo EM, Holmes HM, Ramos D, Ramineni M, Lee JS, Wang DY, Pietropaolo M, Ripley RT, Burt BM, Lee HS "Inhibition of CDK4/6 Overcomes Primary Resistance to PD-1 Blockade in Malignant Mesothelioma." Ann Thorac Surg. 2021 September ; :
Funding
- Individual Investigator Research Awards 2020 (03/01/2020 - 02/28/2023) Grant funding from CPRIT
- the Cancer Prevention and Research Institute of Texas
- Mini-pilot grant from Proteomics Core (02/01/2020 - 01/31/2021) Grant funding from CPRIT
- Investigator-Initiated Sponsored Research (06/01/2021 - 05/31/2024) Grant funding from Samyang Biopharm USA
- Therapeutic targeting of MIC-NKG2D signal to overcome resistance to checkpoint immunotherapy
- Faculty Research Grant (07/01/2021 - 06/30/2022) Grant funding from BCM Michael E. DeBakey Department of Surgery
- DLDCCC Pilot Award (11/01/2021 - 10/31/2022) Grant funding from Dan L Duncan Comprehensive Cancer Center Pilot Grant
- Proteogenomic Intratumoral Heterogeneity of Malignant Pleural Mesothelioma
- Fiscal Year 2021 Peer Reviewed Cancer Research Program Impact Award - Clinical Trial ( Grant funding from Department Of Defense
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