Positions
- Instructor
-
Pathology and Immunology
Baylor College of Medicine
Houston, Texas United States
- Microbial Genetics and Genomics
-
Pathology
Investigative and Genomic Pathology
Texas Children's Microbiome Center
Houston, Texas United States
Addresses
- Texas Children's Hospital (Lab)
-
Texas Children's Microbiome Center
1102 Bates Ave, Feigin Tower
Houston, TX 77030
United States
Phone: (832) 824-8251
spinler@bcm.edu
Education
- Ph.D. from University Of Colorado Health Sciences Center
- 01/2005 - Denver, Colorado United States
- B.S. from Southwest Texas State University
- 01/1998 - San Marcos, Texas United States
- Postdoctoral Training at Baylor College Of Medicine Affiliate Hospitals
- 01/2010 - Houston, Texas United States
Professional Interests
- Microbial Genomics, Non-traditional Therapeutics, Next-generation Probiotics, Antimicrobial Resistance and Microbiome Research
- Health Empowering Humanity
Websites
TCMC - Jennifer K. Spinler, Ph.D.
Videos
Selected Publications
- Spinler JK, Sontakke A, Hollister EB, Venable SF, Oh PL, Balderas MA, Saulnier DM, Mistretta TA, Devaraj S, Walter J, Versalovic J, Highlander SK "From prediction to function: Human-specific ecotypes of Lactobacillus reuteri have diverse probiotic functions." Genome Biol Evol. 2014 Jun 19;6(7):1772-89. Pubmed PMID: 24951561
- Boonma P, Spinler JK, Venable SF, Versalovic J, Tumwasorn S "Lactobacillus rhamnosus L34 and Lactobacillus casei L39 suppress Clostridium difficile-induced IL-8 production by colonic epithelial cells." BMC Microbiol. 2014 Jul 2;14(1):177. Pubmed PMID: 24989059
- Hemarajata P, Spinler JK, Balderas MA, Versalovic J "Identification of a proton-chloride antiporter (EriC) by Himar1 transposon mutagenesis in Lactobacillus reuteri and its role in histamine production." Antonie Van Leeuwenhoek. 2014 Mar;105(3):579-92. Pubmed PMID: 24488273
- Boonma P, Spinler JK, Qin X, Jittaprasatsin C, Muzny DM, Doddapaneni H, Gibbs R, Petrosino J, Tumwasorn S, Versalovic J "Draft genome sequences and description of Lactobacillus rhamnosus strains L31, L34, and L35." Stand Genomic Sci. 2014 Feb 15;9(3):744-54. Pubmed PMID: 25197459
- Thiraworawong T, Spinler JK, Werawatganon D, Klaikeaw N, Venable SF, Versalovic J, Tumwasorn S "Anti-inflammatory properties of gastric-derived Lactobacillus plantarum XB7 in the context of Helicobacter pylori infection." 2014 Jan 5; Pubmed PMID: 24387083
- Hemarajata P, Gao C, Pflughoeft KJ, Thomas CM, Saulnier DM, Spinler JK, Versalovic J "Lactobacillus reuteri-specific immunoregulatory gene rsiR modulates histamine production and immunomodulation by Lactobacillus reuteri." 2013 Jan;195(24):5567-76. Pubmed PMID: 24123819
- Santos F, Spinler JK, Saulnier DM, Molenaar D, Teusink B, de Vos WM, Versalovic J, Hugenholtz J "Functional identification in Lactobacillus reuteri of a PocR-like transcription factor regulating glycerol utilization and vitamin B12 synthesis.." Microb. Cell Fact.. 2011;10:55. Pubmed PMID: 21777454
- Spinler JK, Taweechotipatr M, Rognerud CL, Ou CN, Tumwasorn S, Versalovic J "Human-derived probiotic Lactobacillus reuteri demonstrate antimicrobial activities targeting diverse enteric bacterial pathogens.." Anaerobe. 2008 Jun;14(3):166-71. Pubmed PMID: 18396068
- Oram DM, Must LM, Spinler JK, Twiddy EM, Holmes RK "Analysis of truncated variants of the iron dependent transcriptional regulators from Corynebacterium diphtheriae and Mycobacterium tuberculosis.." FEMS Microbiol. Lett.. 2005 Feb 1;243(1):41282. Pubmed PMID: 15667993
- Spinler JK, Brown A, Ross CL, Boonma P, Conner ME, Savidge TC "Administration of probiotic kefir to mice with Clostridium difficile infection exacerbates disease." Anaerobe. 2016 May 13;40:54-7. Pubmed PMID: 27180007
- Saulnier DM, Santos F, Roos S, Mistretta TA, Spinler JK, Molenaar D, Teusink B, Versalovic J "Exploring Metabolic Pathway Reconstruction and Genome-Wide Expression Profiling in Lactobacillus reuteri to Define Functional Probiotic Features.." PLoS ONE. 2011;6(4):e18783. Pubmed PMID: 21559529
Funding
- Reuterin - Investigation of a Novel Signaling Mechanism in Gut-Microbial Health - #P30 DK056338 Grant funding from Texas Medical Center Digestive Diseases Center Pilot Funds
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