Kathryn Patras, PhD
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Kathryn Patras, PhD
Assistant Professor
Positions
- Assistant Professor
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Molecular Virology and Microbiology
Alkek Center for Metagenomics and Microbiome Research
Baylor College of Medicine
Houston, Texas United States
Education
- Postdoctoral Fellowship at UC San Diego
- La Jolla, California United States
- Pediatrics
- PhD from San Diego State University and UC San Diego
- San Diego, California United States
- Biology
- BS from University of Nebraska-Lincoln
- Lincoln, NE
- Animal Science
Professional Interests
- Mucosal immunity and microbiota of the female urogenital tract
- Group B Streptococcus
- Urinary Tract Infection
Professional Statement
My intent is to understand biological mechanisms dictating interactions between mucosal immunity and microbiota of the female urogenital tract, with applications in both disease pathogenesis and overall women’s reproductive health.Websites
Selected Publications
- "Group B Streptococcus CovR regulation modulates host immune signalling pathways to promote vaginal colonization." ; Pubmed PMID: 23298320
- "Characterization of host immunity during persistent vaginal colonization by Group B Streptococcus." ; Pubmed PMID: 25850655
- "Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches." ; Pubmed PMID: 29520354
- "The murine vaginal microbiota and its perturbation by the human pathogen group B Streptococcus." ; Pubmed PMID: 30477439
- "Augmentation of Urinary Lactoferrin Enhances Host Innate Immune Clearance of Uropathogenic Escherichia coli." ; Pubmed PMID: 31055580
- "Determinants of Group B streptococcal virulence potential amongst vaginal clinical isolates from pregnant women." ; Pubmed PMID: 31851721
- "A novel C5a-derived immunobiotic peptide reduces Streptococcus agalactiae colonization through targeted bacterial killing." ; Pubmed PMID: 23979760
- "Group B streptococcal serine-rich repeat proteins promote interaction with fibrinogen and vaginal colonization." ; Pubmed PMID: 24620021
- "Analysis of two-component systems in group B Streptococcus shows that RgfAC and the novel FspSR modulate virulence and bacterial fitness." ; Pubmed PMID: 24846378
- "Streptococcus salivarius K12 Limits Group B Streptococcus Vaginal Colonization." ; Pubmed PMID: 26077762
- "A Murine Model of Group B Streptococcus Vaginal Colonization." ; Pubmed PMID: 27911391
- "Group B Streptococcus Biofilm Regulatory Protein A Contributes to Bacterial Physiology and Innate Immune Resistance." ; Pubmed PMID: 29868829
- "Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract." ; Pubmed PMID: 28829050
- "Tamm-Horsfall Protein Protects the Urinary Tract against Candida albicans." ; Pubmed PMID: 30297523
Funding
- Characterizing the role of the vaginal microbiota in group B Streptococcus colonization and dissemination Burroughs Wellcome Fund Next Gen Pregnancy Initiative
- Contribution of immune modulation, metabolism, and microbiota to Group B Streptococcal urinary tract infection NIH (NIDDK) R01 DK128053
- Microbiome Discovery and Mechanisms to Combat Antibiotic Resistance at Mucosal surfaces NIH (NIAID) U19 AI157981
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