Email

marco.gallo@bcm.edu

Positions

Associate Professor

Department of Pediatrics
Section of Hematology-Oncology
Baylor College of Medicine
Houston, TX

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, TX

Education

PhD from University of British Columbia

Vancouver, BC Canada

BSc from Simon Fraser University

Burnaby, BC Canada

Postdoctoral Fellowship at Hospital for Sick Children

Toronto, ON Canada

Professional Statement

The goal of Dr. Marco Gallo's research is to discover the mechanisms by which the epigenome and non-coding genome drive tumorigenesis in pediatric and adult brain tumors. His laboratory consists of an integrated team of bioinformaticians and wet lab scientists who investigate the function of epigenetic and chromatin factors and 3D genome architecture in programming stem-like states in brain tumors.

Among other contributions, his research has shed light on the intratumoral organization and evolution of genetic subclones in pediatric high-grade gliomas (Cancer Research, 2019), the link between 3D genome organization and expression of targetable antigens in adult glioblastoma (Genome Research, 2019), how subclonalgenetics influences chromatin organization (Science Advances, 2021) and identified chromatin factors that promote cell state transitions (Nature Communications, 2023).

He has received awards from provincial, national and international organizations, including: the Institute of Cancer Research at the Canadian Institutes of Health Research (CIHR), the Society for Neuro-Oncology and Stand Up To Cancer.

Websites

Selected Publications

• Nikolic A, ... Gallo M "macroH2A2 antagonizes epigenetic programs of stemness in glioblastoma." Nature Communications. 2023;14:3062. Pubmed PMID: 37244935
• Nikolic A, ... Gallo M "Copy-scAT: Deconvoluting single-cell chromatin accessibility of genetic subclones in cancer." Science Advances. 2021;7:abg6045. Pubmed PMID: 34644115
• Johnston M, ... Gallo M "High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma." Genome Research. 2019;29:1211-1222. Pubmed PMID: 31249064
• Chute M, ... Gallo M "Intratumoral genetic and functional heterogeneity in pediatric glioblastoma." Cancer Research. 2019;79:2111-2123. Pubmed PMID: 30877103