Martin M. Matzuk, M.D., Ph.D.
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Positions
- Department Chair
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Pathology and Immunology
Baylor College of Medicine
- Stuart A. Wallace Chair, Robert L. Moody, Sr. Chair, and Professor
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Pathology and Immunology
Baylor College of Medicine
- Director
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Center for Drug Discovery
Baylor College of Medicine
- Director
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Clinical Chemistry
Ben Taub Hospital
- Professor
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Molecular and Human Genetics
Baylor College of Medicine
- Professor
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Pharmacology and Chemical Biology
Baylor College of Medicine
- Professor
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Molecular and Cellular Biology
Baylor College of Medicine
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Education
- BA from University Of Chicago (with Honors)
- 06/1982 - Chicago, IL United States
- PhD from Washington University
- 01/1989 - St. Louis, MO United States
- MD from Washington University School Of Medicine
- 01/1989 - St. Louis, Missouri United States
- Post-Doctoral Fellowship at Baylor College Of Medicine
- 01/1993 - Houston, Texas United States
Honors & Awards
- Member of the National Academy of Sciences
- 04/2014
- Member of The Academy of Medicine, Engineering, and Science of Texas (TAMEST)
- 04/2014
- Fellow of the National Academy of Inventors
- 12/2016
- 5th Int’l Fundacion IVI Award for Best Basic Research Record in Reproductive Medicine
- 04/2013
- NIH MERIT Award
- National Institute of Child Health and Human Development (05/2001 - 04/2011)
- Trainee Mentoring Award
- The Society for the Study of Reproduction (07/2015)
- Dr. Philip Needleman Prize for Excellence in Pharmacology Research
- Washington University School of Medicine (05/1990)
- John R. Rainey, M.D. Research Award
- Texas Society of Pathology (02/1993)
- Experimental Pathologist-in-Training Award
- American Society for Investigative Pathology (04/1993)
- The Michael E. DeBakey, M.D., Excellence in Research Award
- Baylor College of Medicine (11/1995)
- The Richard E. Weitzman Memorial Award
- The Endocrine Society (06/1996)
- The Bruce Stewart Memorial Lecture
- American Society of Reproductive Medicine (04/1998)
- The Inaugural Ernst Knobil Lecture
- University of Pittsburgh (10/1998)
- The HypoCCS Award
- Eli Lilly (11/1999)
- Pfizer Outstanding Investigator Award
- American Society for Investigative Pathology (04/2002)
- The Roy O. Greep Award
- The Endocrine Society (06/2010)
- Distinguished Alumnus Award
- Baylor College of Medicine (03/2019)
Professional Interests
- Chemical biology and drug discovery
- Mammalian reproduction, germ cell biology, infertility, and contraception
- TGF-beta and cell signaling networks in female reproduction
Professional Statement
Reproductive and embryonic development are complex processes which require the coordinate interaction of multiple proteins. The overall research goals of my laboratory are directed at elucidating the critical proteins involved in both normal and abnormal reproductive development. These studies are focusing on both extragonadal regulators such as luteinizing hormone and follicle stimulating hormone and intragonadal regulators such as the inhibins, activins, bone morphogenetic proteins, and growth/differentiation factor 9 (GDF9). These latter proteins are members of the large TGF-β's superfamily of secreted growth factors and appear to play important roles in multiple tissues as endocrine, paracrine, and autocrine mediators during both embryonic and adult development.To characterize the roles of these proteins in mammalian reproduction and development, we have taken a systematic approach to generate "knock-out" mice deficient in a number of these genes using gene targeting, embryonic stem (ES) cell, and CRISPR/Cas9 technology. Analysis of the mice generated in these "loss of function" experiments have revealed the critical roles of several of these proteins in mammalian reproduction, development, and oncogenesis. Initial studies to generate mice deficient in the inhibins have already demonstrated the power of this approach revealing that inhibin is a novel tumor suppressor with specificity for the gonads and the adrenal gland. Similarly, mice lacking GDF9 have defined it as the first oocyte-derived growth factor required for somatic cell function in vivo. Current studies using these transgenic mice as in vivo tools are enabling us to more fully understand the relationship of these proteins in reproduction and oncogenesis, and to develop small molecular contraceptives for targeting male germ cell-specific proteins.
Websites
Selected Publications
- Kiyozumi, D., Noda, T., Yamaguchi, R., Tobita, T., Matsumura, T., Shimada, K., Kodani, M., Kohda, T., Fujihara, Y., Ozawa, M., Yu, Z., Miklossy, G., Bohren, K., Horie, M., Okabe, M., Matzuk, M.M., and Ikawa, M. "NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility." Science. 2020 Jun;368:1132-1135. Pubmed PMID: 32499443
- Dawadi, S., Simmons, N., Miklossy, G., Bohren, K.M., Faver, J.C., Ucisik, M.N., Nyshadham, P., Yu, Z., and Matzuk, M.M. "Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library." Proc Natl Acad Sci USA. 2020 Jul;117(29):16782-16789. Pubmed PMID: 32641511
- Matzuk MM, McKeown MR, Filippakopoulos P, Li Q, Ma L, Agno JE, Lemieux ME, Picaud S, Yu RN, Qi J, Knapp S, Bradner JE "Small-molecule inhibition of BRDT for male contraception." Cell. 2012 Aug 17;150(4):673-84. Pubmed PMID: 22901802
- Matzuk MM and Lamb DJ "The biology of infertility: research advances and clinical challenges.." Nature Medicine. 2008 Nov;14(11):1197-1213. Pubmed PMID: 18989307
- Rajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM "NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression.." Science. 2004 Aug 20;305(5687):1157-9. Pubmed PMID: 15326356
- Burns KH, Viveiros MM, Ren Y, Wang P, DeMayo FJ, Frail DE, Eppig JJ, Matzuk MM "Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos." Science. 2003 Apr 25;300(5619):633-6. Pubmed PMID: 12714744
- Wu X, Wang P, Brown CA, Zilinski CA, Matzuk MM "Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries." Biol. Reprod.. 2003 Sep;69(3):861-7. Pubmed PMID: 12773403
- Matzuk MM, Burns KH, Viveiros MM, Eppig JJ "Intercellular communication in the mammalian ovary: oocytes carry the conversation.." Science. 2002 Jun 21;296(5576):2178-80. Pubmed PMID: 12077402
- Shou W, Aghdasi B, Armstrong DL, Guo Q, Bao S, Charng MJ, Mathews LM, Schneider MD, Hamilton SL, and Matzuk MM "Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12." Nature. 1998 Jan 29;391(6666):489-92. Pubmed PMID: 9461216
- Kumar TR, Wang Y, Lu N, and Matzuk MM "Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility." Nature Genetics. 1997 Feb;15(2):201-204. Pubmed PMID: 9020850
- Dong J, Albertini DF, Nishimori K, Kumar TR, Lu N, Matzuk MM "Growth differentiation factor-9 is required during early ovarian folliculogenesis." Nature. 1996 Oct 10;383(6600):531-5. Pubmed PMID: 8849725
- Matzuk MM, Kumar TR, Bradley A "Different phenotypes for mice deficient in either activins or activin receptor type II." Nature. 1995 Mar 23;374(6520):356-60. Pubmed PMID: 7885474
- Matzuk MM, Finegold MJ, Su JG, Hsueh AJ, and Bradley A "Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice.." Nature. 1992;360(6402):313-319. Pubmed PMID: 1448148
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