Positions
- Associate Professor
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Pathology & Immunology
Baylor College of Medicine
Houston, TX US
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- Department of Pathology and Immunology (Office)
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Baylor College of Medicine
Houston, TX 77030
United States
- Department of Pathology and Immunology (Lab)
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Baylor College of Medicine
Houston, TX 77030
United States
Education
- BS from University of Science and Technology of China
- Hefei, China
- PhD from University of Southern California
- Los Angeles, California
- Postdoctoral Training at NIAMS, NIH
- Bethesda, Maryland
Professional Interests
- Autophagy and apoptosis in immune regulation
- Autoimmunity and inflammation
- Regulation of Memory B cell development and function
- Memory T cell development and function
- HIV cure
- Dendritic cells in immune regulation
Professional Statement
Molecular regulation of autoimmunity and inflammation.We have found that autophagy plays a critical role in the long-term survival of memory B cells against virus infection. In autoimmune and inflammatory diseases, the harmful T lymphocytes and B lymphocytes may activate autophagy and other mechanisms in order to persist in the disease process. We are investigating whether autophagy help to protect the long-term survival of autoimmune memory T cell and memory B cells for the development of autoimmune diseases, and whether autophagy deficiency suppress autoimmune and inflammatory responses.
Mitochondrial autophagy in the regulation of immune responses.
We have previously shown that a Bcl-2 family member, Nix, is critical for the regulation of mitochondrial autophagy during erythroid cell development. However, the mechanisms for Nix in mediated mitochondrial autophagy and its functions in immune responses remain to be elucidated. We identified Nix-interacting proteins by mass spectrometry analyses. We are using the CRISPR/Cas9-mediated gene targeting to delete genes encoding these proteins in cell lines and in mice. We will investigate the functions of these novel Nix-interacting proteins in the regulation of mitochondrial autophagy in immune memory cells.
Websites
Selected Publications
- Gupta SS, Sharp R, Hofferek C, Kuai L, Dorn GW 2nd, Wang J, Chen M. "NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells.." Cell Rep.. 2019 Nov 12;29(7):1862-1877. Pubmed PMID: 31722203
- Chen M, Hong MJ, Sun H, Wang L, Shi X, Gilbert BE, Corry DB, Kheradmand F, Wang J "Essential role for autophagy in the maintenance of immunological memory against influenza infection." Nature Medicine. 2014 May;20:503-510. Pubmed PMID: 24747745
- Kodali, S., Li, M., Budai, M.M., Chen, M., and Wang, J. "Protection of Quiescence and Longevity of Memory B cells by Mitochondrial Autophagy." J. Immunol. 2022;208:1085- 1098. Pubmed PMID: 35101890
- Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, Wang J "Essential role for Nix in autophagic maturation of erythroid cells." Nature. 2008 Jul 10;454:232-235. Pubmed PMID: 18454133
- Jang, A., Sharp, R., Wang, J.M., Feng, Y., Wang, J. and Chen, M. "Dependence on Autophagy for Autoreactive Memory B Cells in the Development of Pristane-Induced Lupus.." Front. Immunology. 2021 Jul 16; Pubmed PMID: 34335611
- Chen M, Kodali S, Jang A, Kuai L, Wang J "Requirement for autophagy in the long-term persistence but not initial formation of memory B cells." J Immunol.. 2015 Mar 15;194:2607-2615. Pubmed PMID: 25672753
- Li M, Liu W, Bauch T, Graviss EA, Arduino RC, Kimata JT, Chen M, Wang J. "Clearance of HIV infection by selective elimination of host cells capable of producing HIV.." Nat Commun.. 2020 Aug 13;11(1) Pubmed PMID: 32792548
- Chen, M. , Li, M., Budai, M.M., Rice, A.P., Kimata, J.T., Mohan, M., and Wang, J. "Clearance of HIV-1 or SIV Reservoirs by Promotion of Apoptosis and Inhibition of Autophagy: Targeting Intracellular Molecules in Cure-Directed Strategies.." J Leukoc Biol. 2022 Mar 31; Pubmed PMID: 35362118
- Gupta SS, Wang J, Chen M. "Metabolic Reprogramming in CD8+ T Cells During Acute Viral Infections.." Front Immunol.. 2020; Pubmed PMID: 32670270
- Chen M, Wang YH, Wang Y, Huang L, Sandoval H, Liu YJ, Wang J "Dendritic cell apoptosis in the maintenance of immune tolerance." Science. 2006 Feb 24;311(5764):1160-4. Pubmed PMID: 16497935
- Zhang J, Kodali S, Chen M, Wang J. "Maintenance of Germinal Center B Cells by Caspase-9 through Promotion of Apoptosis and Inhibition of Necroptosis.." J Immunol.. 2020 Jul 1;205(1):113-120. Pubmed PMID: 32434938
- Chen M, Felix K, Wang J "Critical role for perforin and Fas-dependent killing of dendritic cells in the control of inflammation." Blood. 2012 Jan 5;119(1):127-36. Pubmed PMID: 22042696
- Chen M, Huang L, Wang J "Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity." Blood. 2007 May 15;109:4360-4367. Pubmed PMID: 17227827
- Chen M, Wang J "Initiator caspases in apoptosis signaling pathways." Apoptosis. 2002 Aug;7:313-319. Pubmed PMID: 12101390
- Chen M, Guerrero AD, Huang L, Shabier Z, Pan M, Tan TH, Wang J. "Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members.." J Biol Chem.. 2007 Nov 16;282:33888-33895. Pubmed PMID: 17893147
Memberships
- The American Association of Immunologists
- American Heart Association
- The American Society of Hematology
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