Baylor College of Medicine

Mingxing Teng, Ph.D.

Picture

Teng

Mingxing Teng, Ph.D.

Assistant Professor

Phone

(713) 798-236I

Email

mingxing.teng@bcm.edu

Positions

Assistant Professor: Department of Pathology & Immunology
Center for Drug Discovery
Baylor College of Medicine

Assistant Professor: Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology
Baylor College of Medicine

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine

Addresses

Jan and Dan Duncan Neurological Research Institute Building (Office)
: Room: N.0670.05 (6th Floor)
Houston, TX 77030
United States

Education

PhD from Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences: 07/2015 - Shanghai, China

Postdoctoral Training at Baylor College of Medicine: 07/2018 - Houston, Texas United States

Postdoctoral Training at Dana-Farber Cancer Institute, Harvard Medical School: 01/2022 - Boston, Massachusetts United States

Professional Interests

Chemical Biology
Medicinal Chemistry

Websites

Selected Publications

Miao Q, Kadam VD, Mukherjee A, Tan Z, Teng M.* "Unlocking DCAFs To Catalyze Degrader Development: An Arena for Innovative Approaches." J. Med. Chem. 2023 Sep;66(19):13369-13383. Pubmed PMID: 37738232
Teng M,* Gray NS.* "The rise of degrader drugs." Cell Chem. Biol. 2023 Aug;30(8):864-878. Pubmed PMID: 37494935
Teng M, Jiang J, et al "Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader." Angew. Chem. Int. Ed. Engl. 2023 Apr;62(18):e202302364. Pubmed PMID: 36898968
Teng M,* et al "The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush." J. Med. Chem. 2022 Oct;65(21):14289-14304. Pubmed PMID: 36265019

Teng M, et al "The Dawn of Allosteric BCR-ABL1 Drugs: From a Phenotypic Screening Hit to an Approved Drug." J. Med. Chem. 2022 May;65(11):7581-7594. Pubmed PMID: 35609336
Teng M, Lu W, et al "Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216." J. Med. Chem. 2022 Jan;65(1):747-756. Pubmed PMID: 34965125
Teng M, Jiang J, Ficarro SB, et al "Exploring Ligand-Directed N-Acyl-N-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development." ACS Med. Chem. Lett. 2021 Jul;12(8):1302-1307. Pubmed PMID: 34413960
Teng M, et al "Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface." ACS Med. Chem. Lett. 2020 Apr;11(6):1269-1273. Pubmed PMID: 32551010
Teng M, Jiang J, et al "Development of CDK2 and CDK5 Dual Degrader TMX-2172." Angew. Chem. Int. Ed. Engl. 2020 Aug;59(33):13865-13870. Pubmed PMID: 32415712
Teng M, et al "Discovery of aminocyclohexene analogues as selective and orally bioavailable hNav1.7 inhibitors for analgesia." Bioorg. Med. Chem. Lett. 2017 Nov;27(22):4979-4984. Pubmed PMID: 29037948
Teng M, et al "Total synthesis of the monoterpenoid indole alkaloid (±)-aspidophylline A." Angew. Chem. Int. Ed. Engl. 2014 Jan;53(7):1814-1817. Pubmed PMID: 24481917

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Funding

First-Time Tenure-Track Faculty Recruitment Award - #RR220012: $2,000,000.00 ( 12/01/2021 - 11/30/2026 )