Muralidhar H Premkumar, MBBS, DCH,DNB,MRCPCH, MS
Picture
Positions
- Associate Professor
-
Pediatrics
Neonatology
Baylor College of Medicine
Houston, Texas United States
Addresses
- Pavilion (Clinic)
-
Texas Children's Pavilion for Women
6651 Main St.
Houston, TX 77030
United States
Phone: (832) 826-7980
premkuma@bcm.edu
BCM Neonatology
Education
- M.B.,B.S. from Bangalore Medical College
- 01/1996 - Bangalore, India
- DCH from Mumbai University
- 02/1999 - Mumbai, Maharashtra India
- DNB from Diplomate of National Board of Examinations
- 05/2000 - New Delhi, Delhi India
- MRCPCH from Royal College of Paediatrics and Child Health
- 04/2004 - London, London United Kingdom
- Fellowship in Neonatal-Perinatal from Baylor College of Medicine
- 07/2010 - Houston, Texas United States
- Residency at LTM Medical College
- Mumbai, India
- Pediatrics
- Residency at Royal College of Paediatrics and Child Health
- London, England
- Pediatrics
- MD from Bangalore Medical College
- Bangalore, India
- MS from Baylor College of Medicine
- 01/2017 - Houston, Texas United States
Honors & Awards
- Research Travel Award
- Pediatric Academic Societies Annual Meeting. (05/2010)
- Young Investigator Award
- American Academy of Pediatrics, National Conference and Exhibition 2010, San Franscisco, CA
- AAP-NCE 2010 (10/2010)
- Young Faculty Award
- Southern Society for Pediatric Research Meetings, New Orleans (02/2015)
- SAFMR/SSCI Junior Faculty Research Award
- American Federation of Medical Research/ Southern Society for Pediatric Research (02/2016)
- Norton Rose Fulbright Faculty Excellence Award
- for Teaching and Evaluation
- Baylor College of Medicine (11/2018)
- Star Faculty Award for Excellence in Patient Care
- Baylor College of Medicine (03/2019)
- Outstanding Clinician Award
- Department of Pediatrics (06/2022)
Websites
Division of Neonatology, Texas Children's Hospital, Houston, Tx.
Google Scholar
Twitter page
Selected Publications
- Massieu LA, Anderson DM, Gokulakrishnan G. "Human Milk Supplements: Principles, Practices, and Current Controversies.." Clin Perinatol.. 2020 Jun;47(2):355-368.
- Premkumar MH, Pammi M, Suresh G. "Human milk-derived fortifier versus bovine milk-derived fortifier for prevention of mortality and morbidity in preterm neonates.." Cochrane Database Syst Rev.. 2019 Nov 7;11 Pubmed PMID: 31697857
- Gura K, Premkumar MH, Calkins KL, Puder M "Intravenous Fish Oil Monotherapy as a Source of Calories and Fatty Acids Promotes Age-Appropriate Growth in Pediatric Patients with Intestinal Failure-Associated Liver Disease.." J Pediatr. 2020 Apr;219:98-105. Pubmed PMID: 32059815
- Gura KM, Premkumar MH, Calkins KL, Puder M. "Fish Oil Emulsion Reduces Liver Injury and Liver transplantation in Children with Intestinal Failure-Associated Liver Disease: A Multicenter Integrated Study." 2020 Oct 7;S0022-3476(20)31260-9 Pubmed PMID: 33038344
- Call L1, Molina T2, Stoll B3, Guthrie G4, Chacko S5, Plat J6, Robinson J1, Lin S7, Vonderohe,........Premkumar M, Nielsen J, Fang Z, Olutoye O, Thymann T, Britton R, Sangild P, Burrin D. "Parenteral lipids shape gut bile acid pools and microbiota profiles in the prevention of cholestasis in preterm pigs.." J Lipid Res.. 2020 Apr 29;10.1194/jlr.RA120000652 Pubmed PMID: 32350078
- Robinson JL, Smith VA, Stoll B, Agarwal U, Premkumar MH, Lau P, Cruz SM, Manjarin R, Olutoye OO, Burrin DG, Marini JC. "Prematurity reduces citrulline-arginine-nitric oxide production and precedes the onset of necrotizing enterocolitis in piglets.." Am J Physiol Gastrointest Liver Physiol.. 2018 Jul 26; Pubmed PMID: 30048597
- Erez A, Nagamani SC, Shchelochkov OA, Premkumar MH, Campeau PM, Chen Y, Garg HK, Li L, Mian A, Bertin TK, Black JO, Zeng H, Tang Y, Reddy AK, Summar M, O'Brien WE, Harrison DG, Mitch WE, Marini JC, Aschner JL, Bryan NS, Lee B "Requirement of argininosuccinate lyase for systemic nitric oxide production.." Nat. Med.. 2011;17(12):1619-26. Pubmed PMID: 22081021
- Premkumar MH, Sule G, Nagamani SC, Chakkalakal S, Nordin A, Jain M, Ruan MZ, Bertin T, Dawson BC, Zhang J, Schady D, Bryan NS, Campeau PM, Erez A, Lee B. "Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis.." Am J Physiol Gastrointest Liver Physiol.. 2014 Jun 5;ajpgi.00403.201. Pubmed PMID: 24904080
- Premkumar MH, Carter BA, Hawthorne KM, King K, Abrams SA "High rates of resolution of cholestasis in parenteral nutrition-associated liver disease with fish oil-based lipid emulsion monotherapy.." J. Pediatr.. 2013 Apr;162(4):793-798.e1. Pubmed PMID: 23164314
- Premkumar MH, Carter BA, Hawthorne KM, King K, Abrams SA "Fish oil-based lipid emulsions in the treatment of parenteral nutrition-associated liver disease: An ongoing positive experience." Adv Nutr.. 2014 Jan 1;5:65-70. Pubmed PMID: 24425724
- Stettner N, Rosen C, ...Silberman A, Sarver A, Carmel-Neiderman NN, Eilam R, Biton I, Pevsner-Fischer M, Zmora N, Brandis A, Bahar Halpern K, Mazkereth R, di Bernardo D, Brunetti-Pierri N, Premkumar MH, Dank G, Nagamani SCS, Jung S, Harmelin A, Erez A. "Induction of Nitric-Oxide Metabolism in Enterocytes Alleviates Colitis and Inflammation-Associated Colon Cancer.." Cell Rep.. 2018 May 15;23(7):1962-1976. Pubmed PMID: 29768197
- Molina TL1, Stoll B2, Mohammad M2, Mohila CA3, ..........Premkumar M, Robinson J, Smith V, Teets H, Obelitz-Ryom K, Hagan J, Cruz S, Lau P, Puyau M, Shypailo R, Manjarin R, Butte N, Fang Z, Olutoye O, Thymann T, Sangild P, Burrin D. "New generation lipid emulsions increase brain DHA and improve body composition, but not short-term neurodevelopment in parenterally-fed preterm piglets.." Brain Behav Immun.. 2020 Mar;85:46-56. Pubmed PMID: 31026499
- MohanKumar K, Namachivayam K, Chapalamadugu KC, Garzon SA, Premkumar MH, Tipparaju SM, Maheshwari A. "Smad7 interrupts TGF-β signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing enterocolitis.." Pediatr Res. 2016 Jun;79(6):951-961. Pubmed PMID: 26859364
- Smazal AL, Massieu LA, Gollins L, Hagan JL, Hair AB, Premkumar MH. "Small Proportion of Low-Birth-Weight Infants With Ostomy and Intestinal Failure Due to Short-Bowel Syndrome Achieve Enteral Autonomy Prior to Reanastomosis.." JPEN J Parenter Enteral Nutr.. 2020 May 4;
- Booth C, Premkumar MH, Yannoulis A, Thomson M, Harrison M, Edwards AD "Sustainable use of continuous positive airway pressure in extremely preterm infants during the first week after delivery.." Arch Dis Child Fetal Neonatal Ed.. 2006;91(6):F398-402. Pubmed PMID: 16820391
- Posey JE, Dariya V, Edmonds JL, Lee EI, Probst FJ, Premkumar MH. "Syngnathia and obstructive apnea in a case of popliteal pterygium syndrome.." Eur J Pediatr.. 2014 Dec 12;173(12):1741-1744. Pubmed PMID: 25388409
- Greenough A, Premkumar M, Patel D "Ventilatory strategies for the extremely premature infant.." Paediatr Anaesth. 2008 May;18(5):371-7. Pubmed PMID: 18363629
- Nagamani SC, Campeau PM, Shchelochkov OA, Premkumar MH, Guse K, Brunetti-Pierri N, Chen Y, Sun Q, Tang Y, Palmer D, Reddy AK, Li L, Slesnick TC, Feig DI, Caudle S, Harrison D, Salviati L, Marini JC, Bryan NS, Erez A, Lee B "Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria.." Am. J. Hum. Genet.. 2012 May 4;90(5):836-46. Pubmed PMID: 22541557
- Manglani M, Muralidhar HP, Bhoyar A, Shah R, Lokeshwar MR "Leukemic transformation in Fanconi's anemia.." Indian Pediatr. 1999;36(10):1054-6. Pubmed PMID: 10745320
- Premkumar M, Anumakonda V, Cormican L, Ruiz G, Greenough A "Feeding intolerance due to connatal tuberculosis in a prematurely born infant.." Eur J Pediatr.. 2008 Aug;167(8):955-6. Pubmed PMID: 17885763
- Guthrie G, Premkumar M, Burrin DG "Emerging Clinical Benefits of New-Generation Fat Emulsions in Preterm Neonates." Nutr. Clin. Pract.. 2017 Jun;32(3):326-336. Pubmed PMID: 28129045
- Oosterloo BC, Premkumar M, Stoll B, Olutoye O, Thymann T, Sangild PT, Burrin DG. "Dual purpose use of preterm piglets as a model of pediatric GI disease.." Vet Immunol Immunopathol.. 2014 Feb 24; Pubmed PMID: 24656979
- Premkumar MH, Colen JS, Roth DR, Fernandes CJ "Could scrotoschisis mimic an iatrogenic injury? A case report.." Urology. 2009 Apr;73(4):795-6. Pubmed PMID: 19211136
- Sharma RA, Hiwarkar P, Manglani MV, Muralidhar HP "Acquired pure red cell aplasia in a child.." J Postgrad Med.. 2002 Jan;48:37-8. Pubmed PMID: 12082327
- Premkumar, Muralidhar "Acquired Diseases of the GI tract: Enteritis and Colitis. Organization of Neonatal-Perinatal Medicine Training Program Director's National Neonatal Flipped Classroom Program.." American Academy of Pediatrics. 2018;
- Kesman RA Jr, Mehollin-Ray AR, Lantin-Hermoso R, Colquitt J, Fernandes CJ, Premkumar MH. "When the course deviates from expected: Misplacement of an epicutaneo-caval catheter in a neonate.." 2021 Mar 21; Pubmed PMID: 33706604
- Yakah W, Singh P, Brown J, Stoll B, Burrin DG, Premkumar MH, Otu HH, Gu X, Dillon ST, Liberman TA, Freedman SD, Martin CR. "Parenteral lipid emulsions induce unique ileal fatty acid and metabolomic profiles but do not increase the risk of necrotizing enterocolitis in preterm pigs.." 2020 Nov 25;
- Roxana Fatemizadeh 1, Laura Gollins 2, Joseph Hagan 3, Anne Debuyserie 3, Kristi King 2, Adam M Vogel 4, Kristin L Van Buren 5, Amy B Hair 1, Muralidhar H Premkumar 1 "In neonatal onset surgical short bowel syndrome survival is high, and enteral autonomy is related to residual bowel length." JPEN J Parenter. Enteral Nutr.. 2021 Apr 21; Pubmed PMID: 33881791
- Gura KM, Calkins KL, Premkumar MH, Puder M. "Use of Intravenous Soybean and Fish Oil Emulsions in Pediatric Intestinal Failure-Associated Liver Disease: A Multicenter Integrated Analysis Report on Extrahepatic Adverse Events." J Pediatr.. 2022 Feb;241:173-180. Pubmed PMID: 34695449
- Ahmad I, Premkumar MH, Hair AB, Sullivan KM, Zaniletti I, Sharma J, Nayak SP, Reber KM, Padula M, Brozanski B, DiGeronimo R, Yanowitz TD "Variability in antibiotic duration for necrotizing enterocolitis and outcomes in a large multicenter cohort.." J Perinatol.. 2022 Nov;42(11):1458-1464. Pubmed PMID: 35760891
- Premkumar MH "Short Bowel Syndrome and Dysmotility.." Clin Perinatol. 2022 Jun;49(2):521-536. Pubmed PMID: 35659101
- Premkumar MH, Soraisham A, Bagga N, Massieu LA, Maheshwari A. "Nutritional Management of Short Bowel Syndrome." Clin Perinatol.. 2022 Jun;49(2):555-572. Pubmed PMID: 35659103
- Huff KA, Nayak SP, Ahmad I, DiGeronimo R, Hair A, Kim JH, Markel T, Piazza A, Reber K, Roberts J, Sharma J, Sullivan K, Ahmad KA, Yanowitz T, Premkumar MH. "Patterns of lipid-injectable emulsion use in neonatal intensive care units across the United States: A multi-institution survey.." JPEN J Parenter Enteral Nutr.. 2023 Jan;47(1):51-58. Pubmed PMID: 35689505
- Muralidhar H. Premkumar, MBBS, MRCPCH, MS. ; and Kara L. Calkins, MD, MS. "A Neonatologist’s Perspective: Is the Quest for an “Ideal” Lipid Emulsion Over?." JPEN. 2018 Jan;42(1):12-13. Pubmed PMID: 29359468
Memberships
- Society for Pediatric Research
- Member (12/2013)
- Royal College of Paediatrics and Child Health, London, UK
- Member (03/2004)
- Southern Society for Pediatric Research
- Member (02/2013)
- American Academy of Pediatrics
- Member (07/2007)
Funding
- The intestinal microbiome profile in infants with short bowel syndrome
- $20,000.00 (03/01/2013 - 02/28/2014) Center for Metagenomics and Microbiome Research
- The Role of Cell Specific Contributions of Nitric Oxide in the Pathogenesis of Necrotizing Enterocolitis
- $25,000.00 (03/01/2011 - 02/29/2012) Digestive Diseases Centre- Texas Medical Centre
Languages
Hindi, Kannada
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