Positions
- Professor
-
Center for Precision Environmental Health
Baylor College of Medicine
Houston, Texas United States
- Professor
-
Molecular and Cellular Biology
Baylor College of Medicine
Houston, Texas United States
- Professor
-
Medicine
Baylor College of Medicine
Houston, TX
- Professor
-
Molecular and Human Genetics
Baylor College of Medicine
Houston, TX United States
- Clinical Professor
-
Dell Research Institute
Dell Medical School
Austin, TX
- Faculty Senator
-
Baylor College of Medicine
Houston, Texas United States
Addresses
- Neurosensory Building (Office)
-
One Baylor Plaza
Neurosensory Bldg, BCM 946
Houston77030-3411
United States
richard.finnell@bcm.edu
Education
- PhD from University of Oregon Medical School
- Portland, Oregon United States
- Medical Genetics
- Postdoctoral Fellowship at University of Zurich
- Zurich, Zurich Switzerland
- Embryology
Certifications
- Ph.D. Medical Genetics
- American Board of Medical Genetics and Genomics
- Lifetime certification
Professional Interests
- Neural and cardiovascular developmental defects, and complex human birth defects
- Mentorships
Selected Publications
- Kim J, Lei Y, Guo J, Kim SE, Wlodarczyk BJ, Cabrera RM, Lin YL, Nilsson TK, Zhang T, Ren A, Wang L, Yuan Z, Zheng YF, Wang HY, Finnell RH. "Formate rescues neural tube defects caused by mutations in Slc25a32." Proceedings of the National Academy of Sciences of the United States of America. 2018 May 1;115(18):4690-469. Pubmed PMID: 29666258
- Finnell RH "Clinical and experimental studies linking oxidative metabolism to phenytoin-induced teratogenesis." Science. 1981;211:483-483. Pubmed PMID: 1574173
- Buehler, B.A., D. Delimont, M. van Waes and R.H. Finnell. "Prenatal prediction of risk of the fetal hydantoin syndrome.." New England Journal of Medicine. 1990;322(22):1567-1572. Pubmed PMID: 2336087
- Lu H-C, Tan Q, Rousseaux MWC, Kim J-Y, Wan Y-W, Yeh S-Y, Patel JM, Liu X, Lee Y, Fryer JD, Han J, Finnell RH,. et al. "Regionally distinct roles of ATXN1-CIC complex in ADHD and autism." Nature Genetics. 2017;49:527-536. Pubmed PMID: 28288114
- Fathe K, Person MD and Finnell RH. "The application of a chemical determination of N-homocysteinylation levels in developing mouse embryos: implication for folate responsive birth defects.." Journal of Nutritional Biochemistry. 2015;26:312-318. Pubmed PMID: 25620692
- Piedrahita, J.A., B. Oetama, G.D. Bennett, J. van Waes, B.A. Kamen, J.A. Richardson, S.W. Lacey, R.G.W. Anderson, and R.H. Finnel "Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development." Nature Genetics. 1999;23:228-232. Pubmed PMID: 10508523
- Kim J, Lei Y, Guo J, Kim SE, Wlodarczyk BJ, Cabrera RM, Lin YL, Nilsson TK, Zhang T, Ren A, Wang L, Yuan Z, Zheng YF, Wang HY, Finnell RH "Ormate rescues neural tube defects caused by mutations in Slc25a32." Proc Natl Acad Sci U S A. 2018;115(18):4690-4695. Pubmed PMID: 29666258
- Finnell RH "Phenytoin-induced teratogenesis: a mouse model." Science. 1981;211:483-483. Pubmed PMID: 7455686
- Buehler, B.A., D. Delimont, M. van Waes and R.H. Finnell "Prenatal prediction of risk of the fetal hydantoin syndrome." New England Journal of Medicine. 1991;322(22):1567-1572.
- Cabrera RM, Souder JP, Steele JW, Yeo L, Tukeman G, Gorelick DA and Finnell RH "The antagonism of folate receptor by dolutegravir: developmental toxicity reduction by supplemental folic acid." AIDS. 2019;33(3):1967-1976. Pubmed PMID: 31259764
- Chen Z, Lei Y, Zheng Y, Aguiar-Pulido V, Ross ME, Peng R, Jin L, Zhang T, Finnell RH and Wang H "Threshold for neural tube defect risk by accumulated singleton loss-of-function variants." Cell Res. 2018;28(10):1039-1041. Pubmed PMID: 29976953
Projects
- Folic Acid, Parental Mutation Rates and Risk for Neural Tube Defects
- NIH (08/2015 - 07/2020)
- Finnell Birth Defects Laboratory, BCM
- The project involves testing the hypothesis that folic acid protects embryos from developing neural tube defects by suppressing the spontaneous mutation rate. The studies are conducted in both human and mouse samples.
- Intervention Strategies for Non-Folic Acid Responsive Neural Tube Defects
- NIH (02/2015 - 01/2021)
- Finnell Birth Defects Laboratory, BCM
- This research program is focused on mitochondrial one carbon metabolism and folate transport as it relates to neural tube closure. The work includes characterization of a new mouse knockout Slc25a32 created in the laboratory, and a knockout for Mthfd1l.
- Risk Genes and Environmental Interactions
- NIH (07/2011 - 06/2021)
- Finnell Laboratory BCM and Weill Cornell Medical College
- This is a program project grant where my laboratory works on relationships between one carbon metabolism and reactive oxidative stress. We utilize metabolic and genomic approaches as well. Focus on mouse experiments on GPR161 mutants.
- Epigenetic Studies of Folate Transport and Neural Tube Defects
- March of Dimes (07/2016 - 06/2019)
- Finnell Birth Defects Laboratory BCM and Mt. Sinai Medical Center
- Utilizing our Folr1 knockout mouse and the Mthfd1l knockout mouse developing in the Appling laboratory we hope to better understand how epigenetic signals can interact with folate transport to compromise neural tube closure. We will also perform targeted DNA re-sequencing of selected candidate genes in a NTD cohort with appropriate controls.
- Genomic Signature of Risk for Anti-epileptic Drug Compromised Pregnancies
- (08/2015 - present)
- Finnell Birth Defects Laboratory, BCM
- Infants exposed in utero to the commonly prescribed drugs for controlling seizures in mothers with epilepsy have 3X the risk of being born with a significant structural or developmental defect. We have collected DNA samples from mothers and affected children which we will perform whole genome sequencing to try to develop a risk signature for selected drug exposures and adverse outcomes.
Memberships
- American Society for Human Genetics
- Member
Languages
French, German
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