Timothy Gerald Palzkill, Ph.D.
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Positions
- Chair/Professor
-
Pharmacology and Chemical Biology
Baylor College of Medicine
Houston, TX US
- Cullen Trust for Higher Education Academic Chair
-
Baylor College of Medicine
Houston, Texas United States
Addresses
- Department of Pharmacology (Office)
-
Room: BCMN-N520.1
Houston, TX 77030
United States
Education
- BS from Creighton University
- 05/1983 - Omaha, Nebraska United States
- Biology
- PhD from University Of Iowa
- 04/1988 - Iowa City, Iowa United States
- Genetics
- Post-Doctoral Fellowship at Stanford University
- 01/1991 - Stanford, California United States
Honors & Awards
- Award for Beta-lactamase Research
- E.P. Abraham (01/2009)
- Endowed Chair, The Cullen Trust for Higher Education Academic Chair
- Baylor College of Medicine (07/2007)
- Fellow
- American Academy of Microbiology (01/2002)
- MERIT Award
- National Institutes of Allergy and Infectious Diseases, National Institutes of Health (01/2001)
- Best Overall Course Award for BCM Graduate School Core Curriculum for Molecular Methods course.
- Baylor College of Medicine (06/1998)
- Divisional Lecturer
- Division A Lecture
- American Society for Microbiology (01/1997)
- Excellence in Graduate Education Award
- Baylor College of Medicine, Department of Microbiology and Immunology (06/1996)
- ICAAC Young Investigator Award
- (ICAAC, Interscience Conference on Antimicrobial Agents and Chemotherapy)
- American Society for Microbiology (01/1994)
- Young Investigator Award
- American Society for Microbiology Vector Laboratories (01/1994)
Professional Interests
- Protein structure/function and functional genomics
- Enzymology
- Structural Biology
- Membrane Proteins
- Drug Resistance Mechanisms
- Drug Discovery and Medicinal Chemistry
Websites
Selected Publications
- Palzkill T. "Structural and Mechanistic Basis for Extended-Spectrum Drug-Resistance Mutations in Altering the Specificity of TEM, CTX-M, and KPC ß-lactamases." Front Mol Biosci. 2018 Feb 23;5:16. Pubmed PMID: 29527530
- Chen J, Jiang X, Zhang C, MacKenzie KR, Stossi F, Palzkill T, Wang MC, Wang J "Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria." ACS Sens. 2017 Sep 22;2(9):1257-1261. Pubmed PMID: 28809477
- Patel MP, Hu L, Stojanoski V, Sankaran B, Prasad BVV, Palzkill T. "The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M ?-lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation." Biochemistry. 2017 Jun 14;56(27):3443-3453. Pubmed PMID: 28613873
- Adamski CJ, Palzkill T. "Systematic substitutions at BLIP position 50 result in changes in binding specificity for class A ?-lactamases." BMC Biochem. 2017 Mar 6;18(1):2. Pubmed PMID: 28264645
- Adamski CJ, Palzkill T. "BLIP-II Employs Differential Hotspot Residues To Bind Structurally Similar Staphylococcus aureus PBP2a and Class A ?-Lactamases." Biochemistry. 2017 Feb 17;56(8):1075-1084. Pubmed PMID: 28182405
- Hurwitz AM, Huang W, Kou B, Estes MK, Atmar RL, Palzkill T "Identification and Characterization of Single-Chain Antibodies that Specifically Bind GI Noroviruses." Plos One. 2017 Jan 17;12(1):e0170162. Pubmed PMID: 28095447
- Hurwitz AM, Huang W, Estes MK, Atmar RL, Palzkill T "Deep Sequencing of Phage-displayed Peptide Libraries Reveals Sequence Motif that Detects Norovirus." Protein Eng Des Sel. 2017 Feb;30(2):129-139. Pubmed PMID: 28035012
- Chow DC, Rice K, Huang W, Atmar RL, Palzkill T "Engineering Specificity from Broad to Narrow: Design of a β-Lactamase Inhibitory Protein (BLIP) Variant That Exclusively Binds and Detects KPC β-Lactamase." ACS Infect Dis.. 2016 Dec 9;2(12):969-979. Pubmed PMID: 27756125
- Stojanoski V, Sankaran B, Prasad BV, Poirel, Nordmann, Palzkill T "Structure of the catalytic domain of the colistin resistance enzyme MCR-1." BMC Biol. 2016 Sep 21;14(1):81. Pubmed PMID: 27655155
- Sun Z, Mehta SC, Adamski CJ, Gibbs RA, Palzkill T. "Deep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-?-Lactamase is Fragile to Mutations." Sci Rep.. 2016 Sep;12(6):33195. Pubmed PMID: 27616327
Funding
- Role of Beta-Lactamase Mutations in Antibiotic Resistance - #R01 AI32956-25
- $250,000.00 (07/01/1992 - 12/31/2021) Grant funding from NIH/NIAID
- The goal of this project is to understand how the amino acid sequence determines the structure and activity of class A β-lactamases. This is being accomplished using a random mutagenesis approach to identify amino acid residues in the enzyme that are critical for structure and function. In addition, site-directed mutagenesis, enzyme kinetics and X-ray crystallography are used to understand the molecular basis of substrate specificity and molecular evolution of these enzymes.
- Analysis of metallo-beta-lactamase sequence constraints at high resolution - #R01 AI106863-03
- $250,000.00 (05/15/2013 - 04/30/2018) Grant funding from NIH/NIAID
- The goal of this project is to utilize combinatorial libraries and genetic selections for function in combination with ultra-high-throughput DNA sequencing to define the sequence requirements for metallo-beta-lactamase function with various beta-lactam antibiotics.
- Molecular dissection of Norovirus replication and pathogenesis to develop therapeutics - #P01 AI057788-11
- $251,722.00 (06/01/2015 - 05/31/2020) Grant funding from NIH/NIAID
- (Estes, PI) (Palzkill, Core Director; Co-project director) Program project grant to develop diagnostics and therapeutics for caliciviruses. Projects in this grant include the development of new methods to detect caliciviruses. Palzkill’s role is as director of the Small Molecule and Protein Chemistry Core and co-director of the diagnostic development aspect of the program project.
- Development of Coactivator-Dependent, First-In-Class Therapies for Breast Cancer - #W81XWH-23-1
- $50,000.00 (08/01/2013 - 07/31/2018) Grant funding from DOD
- The goal of this grant is to develop small molecule drugs for cancer therapy via targeting of transcriptional co-activator proteins.
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