Vaishnav Krishnan, M.D., Ph.D.
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Positions
- Assistant Professor
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Neurology, Neuroscience, and Psychiatry & Behavioral Sciences
Baylor College of Medicine
- Principal Investigator
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Laboratory of Epilepsy and Emotional Behavior
Baylor College of Medicine
- Adjunct Assistant Professor
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Electrical and Computer Engineering
Rice University
Addresses
- Laboratory of Epilepsy and Emotional Behavior (Lab)
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6550 Fannin St Smith Tower
Neurosensory BCM NA200
Houston, TX 77030
United States
- Baylor College of Medicine Medical Center (Clinic)
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7200 Cambridge St
9th Floor
Houston, TX 77030
United States
Education
- BS from New York University
- 05/2003 - NY, New York United States
- Neuroscience (Hons), Chemistry
- MD-PhD from University of Texas Southwestern Med. Center Medical Scientist Training Program (MSTP)
- 06/2010 - Dallas, Texas United States
- PhD: Behavioral Neuroscience, Molecular Neuroplasticity
- Internship at Parkland Memorial Hospital/University of Texas Southwestern
- 06/2011 - Dallas, Texas United States
- Internal Medicine
- Residency at Beth Israel Deaconess Medical Center, Harvard Medical School
- 06/2014 - Boston, Massachusetts United States
- Adult Neurology
- Postdoctoral Fellowship at Beth Israel Deaconess Medical Center, Harvard Medical School
- 06/2016 - Boston, Massachusetts United States
- Seizures and autism-related behavior, mouse models of autism and epilepsy
- Clinical Fellowship at Beth Israel Deaconess Medical Center, Harvard Medical School
- 06/2016 - Boston, Massachusetts United States
- Clinical Neurophysiology and Epilepsy
Certifications
- Adult Neurology (2014)
- American Board of Psychiatry and Neurology
- Clinical Neurophysiology (2017)
- American Board of Psychiatry and Neurology
- Epilepsy Medicine (2018)
- American Board of Psychiatry and Neurology
Honors & Awards
- Outstanding Resident Teaching Award
- Harvard Medical School (07/2013)
- NINDS R25 Award
- National Institutes of Neurological Disorders and Stroke (01/2014 - 06/2015)
- Clinical Research Training Fellowship in Epilepsy
- American Academy of Neurology, American Brain Foundation (07/2016 - 08/2018)
- Mentored Clinical Scientist Research Career Development Award K08
- National Institute of Neurological Disorders and Stroke (04/2019 - 03/2024)
- Junior Faculty Seed Grant
- Curtis Hankamer Basic Research Fund (07/2019 - 06/2020)
- Junior Investigator Award
- American Epilepsy Society (10/2020 - 09/2021)
- Mike Hogg Fund Award
- The Mike Hogg Fund (02/2021 - 01/2022)
- Gulf Coast Center for Precision Health Pilot Award
- P30ES030285 (01/2022 - 01/2023)
- Fellow of the American Epilepsy Society (FAES)
- AES (12/2022)
- Associate Course Director: Nervous System (MBNRS MAIN)
- Baylor College of Medicine (07/2020 - 06/2023)
- Course Director: Epilepsy and EEG (MENEU 201)
- Baylor College of Medicine (07/2020 - 06/2023)
- INQUIRY ADVISOR
- Baylor College of Medicine (07/2023)
Professional Interests
- Epilepsy and Mental Health Disorders
- Epilepsy, Intellectual Disability and Neurodevelopmental Delay
- Comorbid treatment-refractory depression AND epilepsy
- Behavioral Phenotyping in Mouse Models of Neuropsychiatric Illness
- Home Cage Monitoring
- Actigraphy and Neuropsychiatric Disability
Professional Statement
I am proud to be a physician-scientist at the Baylor College of Medicine’s Comprehensive Epilepsy Center and the Peter Kellaway Section of Clinical Neurophysiology. In the clinical domain, I am an adult neurologist with subspecialty expertise in the treatment of epilepsy and related disorders (such as functional/psychogenic seizures). As a board-certified clinical neurophysiologist, I read and interpret clinical electroencephalography (EEG) and other intraoperative neurophysiological monitoring studies. My clinical interests focus on caring for patients with epilepsy who are affected by one or more psychiatric comorbidities (including depression, psychogenic nonepileptic seizures, schizophrenia, anxiety disorders and autism), a neurobiological niche that is the scientific focus of my basic science laboratory. In addition to bedside and EEG lab-side teaching, I formally participate in didactic education for medical, graduate and undergraduate students. My prior research focused on applying systems neuroscience to study mouse models of neuropsychiatric disease. For my PhD at the UTSouthwestern Medical Scientist Training Program, I examined how specific molecular changes in mesolimbic dopamine neurons underlie whether a mouse may display a vulnerable or resilient behavioral profile following repeated social stress. During and after residency/fellowship training at the Beth Israel Deaconess Medical Center, I returned to the bench to explore how recurrent seizures induce cascades of neuroplasticity that function to impede sociability/social drive. Today, my laboratory’s research program combines multimodal behavioral telemetry in mice and wearable technologies in patient volunteers to study how seizures, seizure risk (epilepsy) and antiseizure treatments impact spontaneous behavior. This work seeks to improve on treatments for epilepsy spectrum disorders by devising new, translationally fluid behavioral endpoints designed to tease out the determinants of interictal behavior. In doing so, our research defines a new quantitative and objective approach to ascertain the mental status of a mouse.Websites
Selected Publications
- Abboud MA, Kamen JL, Bass JS, Lin, Gavvala JR, Rao S, Smagula SF, Krishnan V "Actigraphic correlates of neuropsychiatric symptoms in adults with focal epilepsy." Epilepsia. 2023 Apr 24; Pubmed PMID: 37029747
- Schirmer C, Abboud MA, Lee SC, Bass JS, Mazumder AG, Kamen JL, Krishnan V. "Home-cage behavior in the Stargazer mutant mouse." Sci Rep. 2022 Jul 27; Pubmed PMID: 35896608
- Bass JS, Tuo AH, Ton LT, Jankovic MJ, Kapadia PK, Schirmer C, Krishnan V "On the Digital Psychopharmacology of Valproic Acid in Mice." Front Neurosci. 2020 Nov 6;14:594612. Pubmed PMID: 33240040
- Krishnan V "Depression and Anxiety in the Epilepsies: from Bench to Bedside." Curr Neurol Neurosci Rep. 2020; Pubmed PMID: 32666148
- Jankovic MJ, Kapadia PP, Krishnan V "Home-cage monitoring ascertains signatures of ictal and interictal behavior in mouse models of generalized seizures.." PLoS One. 2019; Pubmed PMID: 31697745
- Krishnan V, Stoppel DC, Nong Y, Johnson MA, Nadler MJ, Ozkaynak E, Teng BL, Nagakura I, Mohammad F, Silva MA, Peterson S, Cruz TJ, Kasper EM, Arnaout R, Anderson MP. "Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1.." Nature. 2017; Pubmed PMID: 28297715
- Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, Laplant Q, Graham A, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Kumar A, Eisch AJ, Self DW, Lee FS, Tamminga CA, Cooper DC, Gershenfeld HK, Nestler EJ "Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions.." Cell. 2007; Pubmed PMID: 17956738
- Krishnan V, Nestler EJ. "The molecular neurobiology of depression.." Nature. 2008; Pubmed PMID: 18923511
- Krishnan V, Nestler EJ "Linking molecules to mood: new insight into the biology of depression.." Am J Psychiatry. 2010; Pubmed PMID: 20843874
- Krishnan V, Leung LY, Caplan LR. "A neurologist's approach to delirium: diagnosis and management of toxic metabolic encephalopathies.." Eur J Intern Med. 2014; Pubmed PMID: 24332366
- Krishnan, V., Krishnamurthy, KB "Interictal 12-lead electrocardiography in patients with epilepsy.." Epilepsy Behav. 2013; Pubmed PMID: 23992874
- Krishnan V, Nestler EJ "Animal models of depression: molecular perspectives.." Curr Top Behav Neurosci.. 2011; Pubmed PMID: 21225412
Memberships
- American Academy of Neurology
- American Epilepsy Society
- NINDS/AES Epilepsy Benchmark Stewards Committee
- AES Committee on Psychosocial Comorbidities of Epilepsy
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