Shen, M.D., Ph.D.
Shen, M.D., Ph.D.
Division of Cardiothoracic Surgery
Baylor College of Medicine
- Director, Aortic Disease Research Laboratory
Baylor College of Medicine
- Cardiothoracic Surgery Research Laboratory (Lab)
Texas Heart Institute
6770 Bertner Ave.
Houston, TX 77030
Phone: (832) 355-9952
- PhD from University Of New South Wales
- Sydney, NSW Australia
- MD from Beijing Medical College
- Beijing, China
- Aortic aneurysms and dissections
- Diabetic vascular diseases
- Vascular biology and diseases
Professional StatementDr. Ying Shen's research focuses on Vascular Diseases. One of her main interests is in the molecular mechanisms of aortic aneurysms and dissections. During the past few years, she has developed several projects investigating the signaling pathways that control aortic destruction, healing, and remodeling. She has also established mouse models of aortic aneurysms and dissections and used various techniques to evaluate the aortic structure and function. The ultimate goal of Dr. Shen’s research is to use pharmacological treatment to prevent progressive aortic destruction and disease deterioration.
VIICTR Research Database
- Li XN, Song J, Zhang L, LeMaire SA, Hou X, Zhang C, Coselli JS, Chen L, Wang XL, Zhang Y, Shen YH "Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin.." Diabetes.2009/October;58(10):2246-57. Pubmed PMID: 19592618
- Wang XL, Zhang L, Youker K, Zhang MX, Wang J, LeMaire SA, Coselli JS, Shen YH "Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase." Diabetes.2006/August;55(8):2301-10. Pubmed PMID: 16873694
- Wu D, Ren P, Zheng Y, Zhang L, Xu G, Xie W, Lloyd EE, Zhang S, Zhang Q, Curci JA, Coselli JS, Milewicz DM, Shen YH, LeMaire SA. "NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation.." Arterioscler Thromb Vasc Biol.2017/April;37(4):694-706. Pubmed PMID: 28153878
- Mao Y, Luo W, Zhang L, Wu W, Yuan L, Xu H, Song J, Fujiwara K, Abe JI, LeMaire SA, Wang XL, Shen YH. "STING–IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity." Arterioscler Thromb Vasc Biol..2017/May;37(5):920-929. Pubmed PMID: 28302626
- Yuan L, Mao Y, Luo W, Wu W, Xu H, Wang XL, Shen YH "Palmitic acid dysregulates the Hippo-YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS-STING-IRF3 signaling mechanism.." J Biol Chem. 2017 September ; 292(36) : 15002-15015. Pubmed PMID: 28698384
- Luo W, Wang Y, Zhang L, Ren P, Zhang C, Li Y, Azares AR, Zhang M, Guo J, Ghaghada KB, Starosolski ZA, Rajapakshe K, Coarfa C, Li Y, Chen R, Fujiwara K, Abe JI, Coselli JS, Milewicz DM, LeMaire SA, Shen YH "Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture." Circulation. 2020 January ; 141(1) : 42-66. Pubmed PMID: 31887080
- Shen YH, Utama B, Wang J, Raveendran M, Duraisamy S, Waldman WJ, Belcher J, Vercellotti G, Martin D, Mitchelle B, Wang XL "Human cytomegalovirus causes endothelial injury through the ataxia telangiectasia mutant and p53 DNA damage signaling pathways." Circ Res. 2004 May ; 94(10) : 1310-7. Pubmed PMID: 15105295
- Ren P, Hughes M, Krishnamoorthy S, Zou S, Zhang L, Wu D, Zhang C, Curci JA, Coselli JS, Milewicz DM, LeMaire SA, Shen YH. "Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.." Sci Rep. 2017 September 27; 7(1): : 12351.. Pubmed PMID: 28955046
- LeMaire SA, Zhang L, Luo W, Ren P, Azares AR, Wang Y, Zhang C, Coselli JS, Shen YH. "Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice.." JAMA Surg. 2018 September ; 153(9) : e181804.. Pubmed PMID: 30046809
- Wu W, Xu H, Wang Z, Mao Y, Yuan L, Luo W, Cui Z, Cui T, Wang XL, Shen YH "PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury." PLoS One. 2015 10(7) : e0132499. Pubmed PMID: 26161534
- Shen YH, Zhang L, Ren P, Nguyen MT, Zou S, Wu D, Wang XL, Coselli JS, Lemaire SA "AKT2 Confers Protection Against Aortic Aneurysms and Dissections." Circ Res. 2013 February ; 112(4) : 618-32. Pubmed PMID: 23250987
- Li Y, Ren P, Dawson A, Vasquez HG, Ageedi W, Zhang C, Luo W, Chen R, Li Y, Kim S, Lu HS, Cassis LA, Coselli JS, Daugherty A, Shen YH, LeMaire SA. "Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue." Circulation. 2020 October ; 142(14) : 1374-1388. Pubmed PMID: 33017217
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