Eberlin Lab

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Eberlin Lab Publications

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  1. M.W. Towers, R.L. DeHoog, T.M. Godfrey, L.A. Towers, E.A. Jones, J.B. Ballantyne, J.W. Suliburk, L.S. Eberlin. Development of Low-Flow High-Resolution Desorption Electrospray Ionization Mass Spectrometry Imaging. Journal of the American Society for Mass Spectrometry, 2026, Vol.37 (1), p.152-162.
  2. E.C. Williams, L. Franzén, L. M. Olsson, G. Hamm, S. Oag, M.M. Majumder, J. Denholm, A. Hamidinekoo, M.J. Escudero, M. Vicari, J. Lundeberg, L. Setyo, T.M. Godfrey, L.S. Eberlin, A. Zakirov, J.J. Hornberg, M. Stamou, P.L. Ståhl, A. Ollerstam, J.Y. Tan, I. Mohorianu. Spatially resolved integrative analysis of transcriptomic and metabolomic changes in tissue injury studies. Nature communications, 2026, Vol.17 (1), p.205.
  3. C.A. Wolfe, S. Povilaitis, M.F. Keating, A.E. Montgomery, B.M. Burt, A.A. Jazaeri, L.S. Eberlin. Next generation MasSpec pen technology: Innovations in instrumentation and medical device development for intraoperative use. International journal of mass spectrometry, 2025, Vol.518, p.117515, Article 117515.
  4. T.V. Mendes, P.R. Hof, D. Meyer, M. Varghese, L.S. Eberlin. Mass spectrometry imaging of Alzheimer's disease vulnerable and resilient neocortical areas in postmortem formalin‐fixed paraffin‐embedded and fresh frozen human brains. Alzheimer's & dementia, 2025, Vol.21 (S1), p.n/a.
  5. K. Sharma, J. Hasen, K. Susztak, L.S. Eberlin, C.R. Anderton, T. Alexandrov, R. Iyengar, “Spatial metabolomics and multiomics integration for breakthroughs in precision medicine for kidney disease”, Nature Reviews Nephrology, 2025, DOI 10.1038/s41581-025-01007-3.
  6. M.W. Towers, R.L. DeHoog, T.M. Godfrey, L.A. Towers, E.A. Jones, J.B. Ballantyne, J.W. Suliburk, L.S. Eberlin. Development of Low-Flow High-Resolution Desorption Electrospray Ionization Mass Spectrometry Imaging. Journal of the American Society for Mass Spectrometry, 2026, Vol.37 (1), p.152-162.
  7. E.C. Williams, L. Franzén, L. M. Olsson, G. Hamm, S. Oag, M.M. Majumder, J. Denholm, A. Hamidinekoo, M.J. Escudero, M. Vicari, J. Lundeberg, L. Setyo, T.M. Godfrey, L.S. Eberlin, A. Zakirov, J.J. Hornberg, M. Stamou, P.L. Ståhl, A. Ollerstam, J.Y. Tan, I. Mohorianu. Spatially resolved integrative analysis of transcriptomic and metabolomic changes in tissue injury studies. Nature communications, 2026, Vol.17 (1), p.205.
  8. C.A. Wolfe, S. Povilaitis, M.F. Keating, A.E. Montgomery, B.M. Burt, A.A. Jazaeri, L.S. Eberlin. Next generation MasSpec pen technology: Innovations in instrumentation and medical device development for intraoperative use. International journal of mass spectrometry, 2025, Vol.518, p.117515, Article 117515.
  9. T.V. Mendes, P.R. Hof, D. Meyer, M. Varghese, L.S. Eberlin. Mass spectrometry imaging of Alzheimer's disease vulnerable and resilient neocortical areas in postmortem formalin‐fixed paraffin‐embedded and fresh frozen human brains. Alzheimer's & dementia, 2025, Vol.21 (S1), p.n/a.
  10. K. Sharma, J. Hasen, K. Susztak, L.S. Eberlin, C.R. Anderton, T. Alexandrov, R. Iyengar, “Spatial metabolomics and multiomics integration for breakthroughs in precision medicine for kidney disease”, Nature Reviews Nephrology, 2025, DOI 10.1038/s41581-025-01007-3.
  11. R. Dehoog , A. Al-Fartosi , M.N.C. Lin, N. Zarrin-Khameh, R.R. Huang, L.S. Eberlin, J. Suliburk, “Analytical Validation of Desorption Electrospray Ionization Mass Spectrometry Imaging for Classification of Thyroid Fine Needle Aspiration Biopsies”, Clinical Chemistry, 2025, DOI 10.1093/clinchem/hvaf086.722.
  12. T. Godfrey, B. Acidi, P. Fernandes, S. Bench, A.González, W.D. Yu, Y.H. Wang, H.T. Cao, L.S. Eberlin, “Ex-Vivo Evaluation of the MasSpec Pen Technology for Hepatocellular Carcinoma Margin Assessment”, Clinical Chemistry, 2025, DOI 10.1093/clinchem/hvaf086.729.
  13. C.A. Wolfe, S. Povilaitis, M.F. Keating , A.E. Montgomery, B.M. Burt, A.A. Jazaeri, L.S. Eberlin, “Next generation MasSpec pen technology: Innovations in instrumentation and medical device development for intraoperative use”, International Journal of Mass Spectrometry, 2025, DOI 10.1016/j.ijms.2025.117515.
  14. A. Salama, O.H. Ou, M. Dwenger , C. Wells, A. Gebreil, J. Miller, K. Abou FarraJ, Y.B. Nong, R. WahiD , H. Abdelhafez, M. Arai, M. Hamouda, P.R. Mathew, W. Elhelaly, J. Huelsmann, S. Bench, S.W. Kang, V. Rodriguez, D. Kraushaar, H.S. Lee,  L.S. Eberlin,  B. Hill, T. Rosengart, R. Abouleisa, T. Mohamed , “Spontaneously proliferating cardiomyocytes are sensitized to proliferate through retinoic acid dependent signaling”, Circulation Research, 2025, DOI 10.1161/res.137.suppl_1.Thu024.
  15. C.C. Lin, T.L. Pulliam, J.J. Han, J.Q. Xu, C.V. ReciO, S.R.. Wilkenfeld, Y. Shi, M. Kushwaha, S. Bench, E. Ruiz, S. Senthilkumar, J. Dileep , P.D.A. Shepherd, N.M. Navone, A.R. Klekers, E.M. Whitley, M.M. Ittmann , L.S. Eberlin,  W.Y. Wang, D.E. Frigo, “Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer”, Cell Reports, 2025, DOI 10.1016/j.celrep.2025.115792.
  16. M. Lin, E.H. Seeley, S. Ledet , C. Salazar , M.T. Breen, L.S. Eberlin, “Mass spectrometry imaging reveals alterations in protein and N-glycan molecular signatures in endometriosis tissues”, Analytical and Bioanalytical Chemistry, 2025, DOI 10.1007/s00216-025-05930-z.
  17. A. Reis, C.P. Carvalho, I.L. de Lima, F.R.P. Mansoldo, A.B. Vermelho, R.C. Simas, L.S. Eberlin, M.N. Eberlin, “"Touch&Play" Wood Typification by the MasSpec Pen”, Journal of Mass Spectrometry, 2025, DOI10.1002/jms.5133.
  18. A.N. Gatmaitan, K. Weaver , S.P. Badal, H.E. Bird, A. Huhn, C. Hussey, W.A. Clarke, L.S. Eberlin, “Development and Application of the Modular MasSpec Pen System for Clinical Opioid Screening”, Analytical Chemistry, 2025, DOI10.1021/acs.analchem.5c00558.
  19.  T.M. Godfrey, Y. Shanneik,W.Q. Zhang,T. Tran, N. Verbeeck, N.H. Patterson, F.E. Jackobs, C. Nagi, M. Ramineni, L.S. Eberlin, “Integrating Ambient Ionization Mass Spectrometry Imaging and Spatial Transcriptomics on the Same Cancer Tissues to Identify RNA-Metabolite Correlations”, Angewandte Chemie-International Edition, 2025, DOI10.1002/anie.202502028.
  20. T.M. Godfrey, Y. Shanneik, W.Q. Zhang, T. Tran, N. Verbeeck, N.H. Patterson, F.E. Jackobs, M. Ramineni, C. Nagi, L.S. Eberlin, “Integrating spatial metabolomics and spatial transcriptomics on the same cancer tissue sections to detect gene-metabolite correlations”, Cancer Research, 2025, DOI10.1158/1538-7445.AM2025-150.
  21. Y. Shanneik, B. Burt, M. Ramineni, L.S. Eberlin, “Advancing non small cell lung cancer detection and subtyping by MasSpec Pen technology”, Cancer Research, 2025, DOI10.1158/1538-7445.AM2025-4584.
  22. L.Q. Yu, K. Liebenberg, Y.C. Shen, F.S. Liu, Z. Xu, X.X. Hao, L. Wu, W.J. Zhang, h.l. Chan, b. Wei, P.L. Lorenzi, Y. Gao, I. Bado , L. Becerra-Dominguez, C.H. Rivas, S. Aguirre, B.C. Pingel , Y.H. Wu, Y.F. Ding, J. Liu, D.G. Edwards, L.S. Eberlin, X.H.F. Zhang, “Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer”, Immunity, 2025, DOI10.1016/j.immuni.2025.03.002.
  23. J.R. Shuluk , C.D. Wight, J.R. Howard, M.E. King, S.R. Moor, R.J. Dehoog, S.D. Dahlhauser, L.S. Eberlin, E.V. Anslyn, “A Workflow Enabling the Automated Synthesis, Chain-End Degradation, and Rapid Mass Spectrometry Analysis for Molecular Information Storage in Sequence-Defined Oligourethanes”, JACS AU, 2025, DOI10.1021/jacsau.4c01070.
  24. A.L. Seidinger, F.L.T. Silva, M.F. Euzébio, A.C. Krieger, J. Meidanis, J.M. Gutierrez,  T.M.S. Bezerra, L. Queiroz, A.A.R. Silva, I.L. Hoffmann, C.M.M. Daiggi, H. Tedeschi, M.N. Eberlin, L.S. Eberlin, J.A. Yunes, A.M. Porcari, I.A. Cardinalli , “Tumor-Promoted Changes in Pediatric Brain Histology Can Be Distinguished from Normal Parenchyma by Desorption Electrospray Ionization Mass Spectrometry Imaging”, Biomedicines, 2025, DOI10.3390/biomedicines12112593.
  25. K.R.K. Reddy,D.W.B. Piyarathna,, J.H. Park, V. Putluri, A.M. Kamal, J. Xu, D. Kraushaar, S.X. Huang,S.Y.  Jung , L.S. Eberlin, , Kittles, RA, Parsawar, K, Siddiqui, MM, Gao, JJ, Gramer, AL, Bollag, RJ, Terris, MK , Lotan, Y, Creighton, CJ , Lerner, SP, Sreekumar, A, Kaipparettu, BA, Putluri, N, “Mitochondrial reprogramming by activating OXPHOS via glutamine metabolism in African American patients with bladder cancer”, JCI INSIGHT, 2024, DOI10.1172/jci.insight.172336.
  26. N.D. Fleming, C.A. Wolfe, M. Keating, M. Sans, K.M. Rangel, C. Sunny, S.N. Westin, A.A. Jazaeri, P.T. Soliman, J.S. Taylor, R.T. Hillman, J.A. How, B. Lawson,A.K.  Sood, L.S. Eberlin, “Feasibility of using the handheld MasSpec pen technology for intraoperative identification of ovarian cancer during tumor reductive surgery”, Journal of Clinical Oncology, 2024, Volume:4, Issue:16, Supplement:S, Meeting Abstract:5573.
  27. M.F Keating, C.A. Wolfe, K. Liebenberg, A. Montgomery, A.M. Porcari, N.D.A. Fleming, A. Makarov, L. S. Eberlin “Data Acquisition and Intraoperative Tissue Analysis on a Mobile, Battery-Operated Orbitrap Mass Spectrometer”, Analytical Chemistry, 2024, in press
  28. C.L. Feider, A.V. Bensussan, M.F. Keating, J.Q. Lin, M.W. Sun, R.Tibshirani, C. Pirko, K.A. Brahmbhatt, A.R. Al-Fartosi, A.M. Thompson, E. Bonefas, J. Suliburk, S.A. Carter, L.S. Eberlin, “Intraoperative Evaluation of Breast Tissues During Breast Cancer Operations Using the MasSpec Pen”, JAMA Network Open, 2024, 7(3), e242684.
  29. D. Awad, P.H.A. Cao, T.L. Pulliam, M.L. Spradlin, E. Subramani, T.V. Tellman, C.F. Ribeiro, R. Muzzioli, B.E. Jewell, H. Pakula, J.J. Ackroyd, M.M. Murray, J.J. Han, M. Leng, A. Jain, B. Piyarathna, J. Liu, X. Song, J. Zhang, A.R. Klekers, J.M. Drake, M.M. Ittmann, C. Coarfa, D. Piwnica-Worms, M.C. Farach-Carson, M. Loda, L.S. Eberlin, D.E. Frigo, “Adipose triglyceride lipase is a therapeutic target in advanced prostate cancer that promotes metabolic plasticity”, Cancer Research, 2024, 84 (5), 703-724. 
  30. S. Corvigno, S. Badal, M.L Spradlin, M. Keating, I. Pereira, E. Stur, Emine Bayraktar, K.I. Foster, N.W. Bateman, W. Barakat, K.M. Karcy, T.P. Conrads, G.L. Maxwell, P.L. lorenzi, S.K. Lutgendorf, Y. Wen, L. Zhao, P.H. Thaker, M.J. Goodheart, J. Liu, N. Fleming, S. Lee, L.S. Eberlin, A.K. Sood. “In situ profiling reveals metabolic alterations in the tumor microenvironment of ovarian cancer after chemotherapy”, npj Precis. Onc., 2023, 7, 115.
  31. J.R. Chappel, M.E. King, J. Fleming, L.S. Eberlin*, D.M. Reif*, E.S. Baker*, “Aggregated Molecular Phenotype Scores: Enhancing Assessment and Visualization of Mass Spectrometry Imaging Data for Tissue-Based Diagnostics”, Analytical Chemistry, 2023, 95, 34, 12913–12922.
  32. R.J. DeHoog, M.E. King, M.F. Keating, J. Zhang, M. Sans, C.L. Feider, K.Y. Garza, A. Bensussan, A. Krieger, J.Q. Lin, S. Badal, E. Alore, C. Pirko, K. Brahmbhatt, W. Yu, R. Grogan, L.S. Eberlin*, and J. Suliburk*, “Intraoperative Identification of Thyroid and Parathyroid Tissues during Human Cervical Endocrine Surgery using the MasSpec Pen”, JAMA Surgery, 2023, 158 (10), 1050-1059.
    *co-corresponding authors
  33. D. Unsihuay, W.S. Phipps, A.G. Paulovich, J.R. Chapman, A. Ducret, L.S. Eberlin, J.M. Spraggins, R.J.A Goodwin. “Tissue Mass Spectrometry: How Solid Is Our Future?”, Clinical Chemistry, 2023, 69(7):676-683.
  34. R.J. DeHoog, M. Lin, G. Roman, R. Martin, J. Suliburk, and L.S. Eberlin, “Evaluating the Generalizability of Predictive Classifiers Built from DESI Imaging Lipid Data across Mass Spectrometry Platforms”, Journal of the American Society for Mass Spectrometry, 2023, 34, 7, 1532-1537.
    36.    L.S. Eberlin, “Disease Detection and Diagnostics: Multidisciplinary Approaches to Address Medical challenges”, JACS Au, 2023, 3, 5, 1264–1266.
  35. A.C. Krieger, L.A. Macias, J.C. Goodman, J.S. Brodbelt, and L.S. Eberlin, “Mass Spectrometry Imaging Reveals Abnormalities in Cardiolipin Composition and Distribution in Astrocytoma Tumor Tissues”, Cancers, 2023, 15, 2842.
  36. M.E. King, R. Yuan, J. Chen. K. Pradhan, I. Sariol, S. Li, A. Chakraborty, O. Ekpenyong, J.H. Yearley, J.C. Wong, L. Zúñiga, D. Tomazela, M. Beaumont*, J.H. Han*, and L.S. Eberlin*, “Long-chain polyunsaturated lipids associated with responsiveness to anti-PD-1 therapy are colocalized with immune infiltrates in the tumor microenvironment”, Journal of Biological Chemistry, 2023, 299, 3, 102902.
    *co-corresponding authors
  37. M.E. King, M. Lin, M. Spradlin, and L.S. Eberlin, “Advances and Emerging Medical Applications of Direct Mass Spectrometry Technologies for Tissue Analysis”, Annual Reviews in Analytical Chemistry, 2023, 16, 1-25.
  38. D. Glassman, M.S. Kim, M. Spradlin, S. Badal, M. Taki, P. Bhattacharya, P. Dutta, C.V. Kingsley, K.I. Foster, O. Animasahun, J.H. Jeon, A. Achreja, A. Jayaraman, P. Kumar, M. Nenwani, F. Wuchu. E. Bayraktar, Y. Wu, E. Stur, L. Mangala, S. Lee, T.A. Yap, S.N. Westin, L.S. Eberlin, D. Nagrath, A.K. Sood, “Exploiting metabolic vulnerabilities after anti-VEGF antibody therapy in ovarian cancer”, iScience, 2023, 106020.
  39. A.V. Moura, D.C. de Oliveira, A.A.R. Silva, J.R. da Rosa, P.H.D. Garcia, P.H.G. Sanches, K.Y. Garza, F.M.M. Mendes, M. Lambert, J.M. Gutierrez, N.M. Granado, A.C dos Santos, I.L. de Lima, L.D. de Oliveira Negrini, M.A. Antonio, M.N. Eberlin, L.S. Eberlin, A.M. Porcari, “Urine Metabolites Enable Fast Detection of COVID-19 Using Mass Spectrometry”, Metabolites, 2022, 12(11):1056.
  40. S.C. Povilaitis, A. Chakraborty, L.M. Kirkpatrick, R.D. Downey, S.B. Hauger, L.S. Eberlin, “Identifying Clinically Relevant Bacteria Directly from Culture and Clinical Samples with a Handheld Mass Spectrometry Probe”, Clinical Chemistry, 2022, 68, 11, 1459-1470.
  41. K.F. Handley, T.T. Sims, N.W. Bateman, D. Glassman, K.I. Foster, S. Lee, J. Yao, H. Yao, B.M. Fellman, J. Liu, Z. Lu, K.A. Conrads, B.L. Hood, W. Barakat, L. Zhao, J. Zhang, S.N. Westin, MD, J. Celestino, K.M. Rangel, S. Badal, I. Pereira, P.T. Ram, G. L. Maxwell, L.S. Eberlin, A. Futreal, R.C. Bast, N.D. Fleming, T.P. Conrads, A.K. Sood “Classification of High-Grade Serous Ovarian Cancer Using Tumor Morphologic Characteristics”, JAMA network Open, 2022, 5, p.e2236626.
  42. M. Lin, M.S. Blevins, M. Sans, J.S. Brodbelt, L.S. Eberlin, “Deeper Understanding of Solvent-Based Ambient Ionization Mass Spectrometry: Are Molecular Profiles Primarily Dictated by Extraction Mechanisms?”, Analytical Chemistry, 2022, 94, 42, 14734-14744.
  43. A.C. Krieger, S.C. Povilaitis, P. Gowda, L.A. O’Connell, L.S.Eberlin, “Noninvasive Detection of Chemical Defenses in Poison Frogs Using the MasSpec Pen”, American Chemical Society, 2022, 2, 5, 475-484. 
  44. M. Lin, L.S. Eberlin, E. Seeley, “Reduced Hemoglobin Signal and Improved Detection of Endogenous Proteins in Blood-Rich Tissues for MALDI Mass Spectrometry Imaging”, Journal of the American Society for Mass Spectrometry, 2022, 33, 296–303.
  45. L. Macias, K.Y. Garza, C.L. Feider, L.S. Eberlin, J.S. Brodbelt, “Relative Quantitation of Unsaturated Phosphatidylcholines using 193 nm Ultraviolet Photodissociation Parallel Reaction Monitoring Mass Spectrometry”, Journal of the American Chemical Society, 2021, 143, 14622–14634. 
  46. K. Y. Garza, A. A. Silva, J. R. Rosa, M. F. Keating, S. C. Povilaitis, M. Spradlin, P. H. Sanches, A. Varao Moura, J. Marrero Gutierrez, J. Q. Lin, J. Zhang, R. J. DeHoog, A. Bensussan, S. Badal, D. Cardoso de Oliveira, P. H. Dias Garcia, L. Dias de Oliveira Negrini, M. Antonio, T. C. Canevari, M. N. Eberlin, R. Tibshirani, L. S. Eberlin*, and A. M. Porcari*, “Rapid screening of COVID-19 directly from Clinical Nasopharyngeal Swabs using The MasSpec Pen,” Analytical Chemistry, 2021, 93, 12582–12593.
    *co-corresponding authors
  47. M. E. King, J. Zhang, J.Q. Lin, K.Y. Garza, R.J. DeHoog, C.L. Feider, A. Bensussan, M. Sans, A. Krieger, S. Badal, M.F. Keating, S. Woody, S. Dhingra, W. Yu, C. Pirko, K. Brahmbhatt, G.Van Buren, W.E. Fisher, J. Suliburk, and L.S. Eberlin, “Rapid Diagnosis and Tumor Margin Assessment During Pancreatic Cancer Surgery with the MasSpec Pen Technology”, Proceedings of the National Academy of Sciences U.S.A., 2021, 118, e2104411118. 
  48. J. Zhang, M. Sans, R.J. DeHoog, K.Y. Garza, M.E. King, C.L. Feider, A. Bensussan, M.F. Keating, J.Q. Lin, S. Povilaitis, N. Katta, T.E. Milner, W. Yu, C. Nagi, S. Dhingra, C. Pirko, K.A. Brahmbhatt, G. Van Buren, S. Carter, A. Thompson, R.H. Grogan, J. Suliburk, and L.S. Eberlin, “Clinical Translation and Evaluation of the MasSpec Pen Technology for Surgical Use”, Clinical Chemistry, 2021, 67, 1271–1280. 
  49. C.L. Feider, A. Gatmaitan, T. Hooper, A. Chakraborty, P. Gowda, E. Buchanan, and L.S. Eberlin, “Integrating the MasSpec Pen with Sub-Atmospheric Pressure Chemical Ionization for Rapid Chemical Analysis and Forensic Applications”, Analytical Chemistry, 2021, 93, 21, 7549–7556.
  50. A. Vaughn, R.J. DeHoog, L.S. Eberlin, and D. R. Appling, “Metabotype analysis of Mthfd1l-null mouse embryos using desorption electrospray ionization imaging mass spectrometry”, Analytical and Bioanalytical Chemistry, 2021, 413, 3573–3582.
  51. A. N. Gatmaitan, J. Q. Lin, J. Zhang, and L. S. Eberlin, “Rapid Analysis and Authentication of Meat Using the MasSpec Pen Technology,” Journal of Agricultural and Food Chemistry, 2021, 69, 11, 3527–3536. 
  52. A. V. Bensussan, J. Lin, C. Guo, R. Katz, S. Krishnamurthy, E. Cressman, and L. S. Eberlin, “Distinguishing Non-Small Cell Lung Cancer Subtypes in Fine Needle Aspiration Biopsies by Desorption Electrospray Ionization Mass Spectrometry Imaging,” Clinical Chemistry, 2020, 66, 1424-1433. †featured on cover
  53. J. Zhang, M. Sans, K. Y. Garza, and L. S. Eberlin, “Mass Spectrometry Technologies to Advance Care for Cancer Patients in Clinical and Intraoperative Use,” Mass Spectrometry Reviews, 2020, DOI: 10.1002/mas.21664.
  54. G. Zhang, J. Zhang, R.J. DeHoog, S. Pennathur, C.R. Anderton, M.A. Venkatachalam, T. Alexandrov, L.S. Eberlin, and K. Sharma, “DESI MSI and METASPACE indicates lipid abnormalities and altered mitochondrial membrane components in diabetic renal proximal tubules”, Metabolomics, 2020, 16, 11. 
  55. M. F. Keating, J. Zhang, C. L. Feider, S. Retailleau, R. Reid, A. Antaris, B. Hart, G. Tan, T. E. Milner, K. Miller, and L. S. Eberlin, “Integrating the MasSpec Pen to the da Vinci Surgical System for In Vivo Tissue Analysis during a Robotic Assisted Porcine Surgery,” Analytical Chemistry, 2020, 92, 11535-11542.
  56. C.L. Feider, L.A. Macias, J. Brodbelt, and L.S. Eberlin, “Double Bond Characterization of Free Fatty Acids Directly from Biological Tissues by Ultraviolet Photodissociation”, Analytical Chemistry, 2020, 92, 8396-8395.
  57. M. Sans, A. Krieger, B.R. Wygant, K.Y. Garza, B.C. Mullins, and L.S. Eberlin, “Spatially Controlled Molecular Analysis of Biological Samples Using Nanodroplet Arrays and Direct Droplet Aspiration,” Journal of the American Society for Mass Spectromtry. 2020, 31, 418-428. 
  58. J. Zhang, S. Q. Li, J. Q. Lin, W. Yu, and L. S. Eberlin, “Mass Spectrometry Imaging enables Discrimination of Renal Oncocytoma from Renal Cell Cancer Subtypes and Normal Kidney Tissues,” Cancer Research, 2020, 80, 689-698.
  59. L.A. Macias, C.L. Feider, L.S. Eberlin, and J.S. Brodbelt, “Hybrid 193 nm Ultraviolet Photodissociation Mass Spectrometry Localizes Cardiolipin Unsaturations,” Analytical Chemistry, 2019, 91, 12509-12516
  60. R. DeHoog, J. Zhang, E. Alore, J.Q. Lin, W. Yu, S. Woody, C. Almendariz, M. Lin, A.F. Engelsman, S.B. Sidhu, R. Tibshirani, J. Suliburk, and L.S. Eberlin, “Preoperative Metabolic Classification of Thyroid Nodules using Mass Spectrometry Imaging of Fine Needle Aspiration Biopsies,” Proceedings of the National Academy of Sciences U.S.A. 2019, 116, 21401-21408.
  61. C.L. Feider, S. Woody, S. Ledet, J. Zhang, K. Sebastian, M.T. Breen, and L.S. Eberlin, “Molecular Imaging of Endometriosis Tissues using Desorption Electrospray Ionization Mass Spectrometry,” Scientific Reports. 2019, 9, 15690.
  62. C.L. Feider, A. Krieger, R.J. DeHoog, and L.S. Eberlin, “Ambient Ionization Mass Spectrometry: Recent Developments and Applications,” Analytical Chemistry, 2019, 91, 4266-4290
  63. M. Sans, J. Zhang, J.Q. Lin, C.L. Feider, N. Giese, M.T. Breen, K. Sebastian, J. Liu, A.K. Sood, and L.S. Eberlin, “Performance of the MasSpec Pen for Rapid Diagnosis of Ovarian Cancer,” Clinical Chemistry 2019, 65, 674-683. *featured on cover
  64. C.L. Feider, R.J. DeHoog, M. Sans, J. Zhang, A. Krieger, and L.S. Eberlin, “DESI Spray Stability in the Negative Ion Mode Is Dependent on Relative Humidity,” Journal of the American Society for Mass Spectrometry, 2019, 30, 376-380.
  65. O. Simoska, M. Sans, M.D. Fitzpatrick, C.M. Crittenden, L.S. Eberlin, J.B. Shear, and K.J. Stevenson, “Real-Time Electrochemical Detection of Pseudomonas aeruginosa Phenazine Metabolites Using Transparent Carbon Ultramicroelectrode Arrays,” ACS Sensors, 2019, 4, 170-179.
  66. A.M. Porcari, J. Zhang, K.Y. Garza, R.M. Rodrigues-Peres, J. Lin, J.H. Young, R. Tibshirani, C. Nagi, G.R. Paiva, S.A. Carter, L.O. Sarian, M.N. Eberlin, and L.S. Eberlin, “A Multi-Center Study Using Desorption Electrospray Ionization Mass Spectrometry Imaging for Breast Cancer Diagnosis” Analytical Chemistry, 2018, 90, 11324–11332. 
  67. D.R. Klein, C.L. Feider, K.Y. Garza, J.Q. Lin, L.S. Eberlin, and J.S. Brodbelt, “Desorption Electrospray Ionization Coupled with Ultraviolet Photodissociation for Characterization of Phospholipid Isomers in Tissue Sections,” Analytical Chemistry, 2018, 90, 10100-10104. 
  68. K.Y. Garza, C. Feider, D.R. Klein, J. Rosenberg, J.S. Brodbelt, and L.S. Eberlin, “Desorption Electrospray Ionization Mass Spectrometry Imaging of Proteins Directly from Biological Tissue Sections,” Analytical Chemistry 2018, 90, 7785-7789. 
  69. Gharpure, S. Pradeep, M. Sans, R. Rupaimoole, C. Ivan, S.Y. Wu, A.S. Nagaraja, L.S. Mangala, X. Zhang, M. Haemmerle, W. Hu, C. Rodriguez-Aguayo, M. McGuire, G.A. Pena, R. Kondetimmanahalli, R. Nini, P. Koppula, P. Ram, S.L. Tucker, G. Lopez-Berestein, K. Baggerly, L.S. Eberlin, and A.K. Sood, “FABP4 as a molecular determinant of residual disease in ovarian cancer”, Nature Communications, 2018, 9:2923.
  70. M. Sans, C.L. Feider, and Livia S. Eberlin, “Advances in Mass Spectrometry Imaging coupled to Ion Mobility Spectrometry for Enhanced Imaging of Biological Tissues”, Current Opinion in Chemical Biology, 2017, 42, 138-146. 
  71. J. Zhang, J. Rector, J. Lin, J.H. Young, M. Sans, N. Katta, N. Giese, W. Yu, C. Nagi, J. Suliburk, J. Liu, A. Bensussan, R.J. DeHoog, K.Y. Garza, B. Ludolph, A.G.Sorace, A. Syed, A. Zahedivash, T. Milner, and L.S. Eberlin, “Nondestructive Tissue Analysis for Ex Vivo and In Vivo Cancer Diagnosis using a Handheld Mass Spectrometry System”, Science Translational Medicine, 2017, 9, eaan3968. †featured in the cover; Altmetric Score: 1679
    76. 
  72. M. Sans, K. Gharpure, R. Tibshirani, J. Zhang, L. Liang, J. Liu, A.K. Sood, and L. S. Eberlin, “Metabolic Markers and Statistical Prediction of Serous Ovarian Cancer Aggressiveness by Ambient Ionization Mass Spectrometry Imaging”, Cancer Research, 2017, 77, 2903-2913.
  73. J. Zhang, C. Feider, C. Nagi, W. Yu, S. A. Carter, J. Suliburk, H. S. Tran Cao, and L. S. Eberlin, “Detection of Metastatic Breast and Thyroid Cancer in Lymph Nodes by Desorption Electrospray Ionization Mass Spectrometry Imaging”, Journal of the American Society of Mass Spectrometry, 2017, 28, 1166-1174. 
  74. C.L. Feider, N. Elizondo, and L.S. Eberlin, “Ambient Ionization and FAIMS Mass Spectrometry for Enhanced Imaging of Multiply Charged Molecular Ions in Biological Tissues”, Analytical Chemistry, 2016, 88, 11533-11541.
  75. J. Zhang, W. Yu, S. Ryu, J. Lin, G. Buentello, R. Tibshirani, J. Suliburk, and L.S. Eberlin, “Cardiolipins are biomarkers of mitochondria-rich thyroid oncocytic tumors”, Cancer Research, 2016, 76, 6588-6597.
  76.  J. Zhang, W. Yu, J. Suliburk, and L.S. Eberlin, “Will ambient ionization mass spectrometry become an integral technology in the operating room of the future?”, Clinical Chemistry, 2016, 62, 1172-1174.
  77. D.R. Ifa and L.S. Eberlin, “Ambient Ionization Mass Spectrometry for Cancer Diagnosis and Surgical Margin Evaluation”, Clinical Chemistry, 2016, 62, 111-123.
  78. A.M. Gouw, L.S. Eberlin, K. Margulis, D.K. Sullivan, G.G. Toal, L. Tong, R.N. Zare, D.W. Felsher, “Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma”, Proceedings of the National Academy of Sciences U.S.A., 2017, 114, 4300-4305.
  79. L.S. Eberlin, K. Margulis, I. Planell-Mendez, R.N. Zare, R. Tibshirani, T.A. Longacre, M. Jalali, J.A. Norton, and G.A. Poultsides, “Pancreatic Cancer Surgical Resection Margins: Molecular Assessment by Mass Spectrometry Imaging”, Plos Medicine, 2016, 13, e1002108.
  80. M.T. Dulay, L.S. Eberlin, and R.N. Zare, “Protein Analysis by Ambient Ionization Mass Spectrometry Using Trypsin-Immobilized Organosiloxane Polymer Surfaces”, Analytical Chemistry, 2015, 87, 12324-12330.  
  81. E.H. Shroff, L.S. Eberlin, V.M. Dang, A.M. Guow, M. Gabay, S.J. Adam, D.I. Bellovin, P.T. Tran, W.M. Philbrick, A. Garcia-Ocana, S.C. Casey, Y.L. Li, C.V. Dang, R.N. Zare and D.W. Felsher, “MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism”, Proceedings of the National Academy of Sciences U.S.A., 2015, 112, 6539-6544.   
  82. K.D. Bemis, A. Harry, L.S. Eberlin, C. Ferreira, S.M. van de Ven, P. Mallick, M. Stolowitz, O. Vitek, “Cardinal: an R package for statistical analysis of mass spectrometry-based imaging experiments”, Bioinformatics, 2015, 31, 2418-2420.
  83. E.H. Shroff, L.S. Eberlin, V.M. Dang, A.M. Guow, M. Gabay, S.J. Adam, D.I. Bellovin, P.T. Tran, W.M. Philbrick, A. Garcia-Ocana, S.C. Casey, Y.L. Li, C.V. Dang, R.N. Zare and D.W. Felsher, “MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism”, Proceedings of the National Academy of Sciences of the U.S.A., 2015, 112, 6539-6544.   
  84. L.S. Eberlin, M. Gabay, A.C. Fan, R. Tibshirani, D. Felsher, and R.N. Zare, “Alteration of the Lipid Profile in Lymphomas Induced by MYC Overexpression”, Proceedings of the National Academy of Sciences of the U.S.A., 2014, 111, 10450-10455.   
  85. L.S. Eberlin, J.V. Mulcahy, A. Tzabazis, J. Zhang, M. Logan, H.J. Roberts, G.K. Lee, D.C. Yeomans, J. Du Bois, and R.N. Zare, “Visualizing Dermal Permeation of Sodium Channel Modulators by Mass Spectrometric Imaging”, Journal of the American Chemical Society, 2014, 136, 6401-6405. 
  86. L.S. Eberlin, R. Tibshirani, J. Zhang, T.A. Longacre, G. Berry, D.B. Bingham, J.A. Norton, R.N. Zare and G.A. Poultsides, “Molecular Assessment of Gastric Cancer Surgical Resection Margins by Mass Spectrometric Imaging”, Proceedings of the National Academy of Sciences of the U.S.A., 2014, 111, 2436-2441.
  87. S. Santagata*, L.S. Eberlin*, I. Norton, D. Calligaris, D.R. Feldman, J.L. Ide, X. Liu, J.S. Wiley, M.L. Vestal, S.H. Ramkissoon, D.A. Orringer, K.K. Gill, I.F. Dunn, D. Dias-Santagata, K.L. Ligon, F.A. Jolesz, A.J. Golby, R.G. Cooks, and N.Y.R. Agar, “Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery”, Proceedings of the National Academy of Sciences of the U.S.A., 2014, 111, 11121-11126. [*equal contribution]
  88. D. Calligaris, I. Norton, D.R. Feldman, J.L. Ide, I.F. Dunn, L.S. Eberlin, R.G. Cooks, F.A. Jolesz, A.J. Golby, S. Santagata and N.Y.R. Agar, “ Mass spectrometry imaging as a tool for surgical decision-making”, Journal of Mass Spectrometry, 2013, 48, 1178-1187.  
  89. L.S. Eberlin, I. Norton, D. Orringer, I. F. Dunn, X. Liu, J.L. Ide, A.K. Jarmusch, K.L. Ligon, F.A. Jolesz, A.J. Golby, S. Santagata, N.Y. R. Agar and R.G. Cooks, “Ambient Mass Spectrometry for the Intraoperative Molecular Diagnosis of Human Brain Tumors”, Proceedings of the National Academy of Sciences of the U. S.A., 2013, 110, 1611-1616.
  90. B. Gholami, I. Norton, L.S. Eberlin, N.Y.R. Agar, “A Statistical Modeling Approach for Tumor-Type Identification in Surgical Neuropathology Using Tissue Mass Spectrometry Imaging”, IEEE Journal of Biomedical and Health Informatics, 2013, 17, 734-744
  91. C. Wu, A.L. Dill, L.S. Eberlin, R.G. Cooks and Demian R. Ifa, “Mass Spectrometry Imaging under Ambient Conditions”, Mass Spectrometry Reviews, 2013, 32, 218-243.
  92. A.H.L. Machado, H.M.S. Milagre, L.S. Eberlin, A.A. Sabino, C.R.D. Correia, M.N. Eberlin, “Dba-free palladium intermediates of the Heck-Matsuda reaction”, Organic & Biomolecular Chemistry, 2013, 11, 3277-3281.
  93. A.F. Gonzalez-Serrano, V. Pirro, C.R. Ferreira, P. Oliveri, L.S. Eberlin, J. Heinzmann, A. Lucas-Hahn, H. Niemann and R.G. Cooks, “Desorption Electrospray Ionization Reveals Lipid Metabolism of Individual Oocytes and Embryos”, PloS ONE, 2013, 8, e74981.
  94. L.S. Eberlin, I. Norton, A.L. Dill, A.J. Golby, K.L. Ligon, S. Santagata, R.G. Cooks and N.Y.R. Agar, "Classifying Human Brain Tumors by Lipid Imaging with Mass Spectrometry", Cancer Research, 2012, 72, 645-654.
  95. A.K. Badu-Tawiah, L.S. Eberlin, Z. Ouyang and R.G. Cooks, "Chemical Aspects of the Extractive Methods of Ambient Ionization Mass Spectrometry", Annual Review of Analytical Chemistry, 2013, 64,481-505.
  96. C.R. Ferreira, V. Pirro, L.S. Eberlin, J.E. Hallett and R.G. Cooks, "Developmental Phases in Individual Mouse Preimplantation Embryos Characterized by Lipid Signatures in Desorption Electrospray Ionization Mass Spectrometry", Analytical and Bioanalytical Chemistry, 2012, 404, 2915-2926.
    101.    D.I. Campbell, C.R. Ferreira, L.S. Eberlin, R.G. Cooks, "Improved spatial resolution in the imaging of biological tissue using desorption electrospray ionization", Analytical and Bioanalytical Chemistry, 2012, 404, 389 -398.
  97. X. Xiong, W. Xu, L.S. Eberlin, J.M. Wiseman, X.Fang, Y. Jiang, Z. Huang, Y. Zhang, R.G. Cooks, Z. Ouyang, “Data processing for 3D mass spectrometry imaging”, Journal of the American Society of Mass Spectrometry, 2012, 23, 1147 - 1156.
  98. V. Pirro, L.S. Eberlin, P. Oliveri, R.G. Cooks, “Interactive hyperspectral approach for exploring and interpreting DESI-MS images of cancer and normal tissue sections”, Analyst, 2012, 137, 2374 - 2380.
  99. C.R. Ferreira, L.S. Eberlin, J.E. Hallett, R.G. Cooks, "Single oocyte and single embryo lipid analysis by desorption electrospray ionization mass spectrometry", Journal of Mass Spectrometry, 2012, 47, 28-32.
    105.    L.S. Eberlin, X. Liu, C.R. Ferreira, S. Santagata, N.Y.R. Agar, R.G. Cooks, "Desorption electrospray ionization then MALDI mass spectrometry imaging of lipid and protein distributions in single tissue sections", Analytical Chemistry, 2011, 83, 8366-8371.
  100. L.S. Eberlin, C.R. Ferreira, A.L. Dill, L.Cheng and R.G. Cooks, "Non-Destructive, Histologically Compatible Tissue Imaging by Desorption Electrospray Ionization Mass Spectrometry", ChemBioChem, 2011, 12, 2129 -2132.
  101. A.L. Dill, L.S. Eberlin, A.B. Costa, D.R. Ifa, R.G. Cooks, "Data Quality in Tissue Analysis using Desorption Electrospray Ionization", Analytical and Bioanalytical Chemistry, 2011, 401, 1949 -1961.
  102. L.S. Eberlin, C.R. Ferreira, A.L. Dill, D.R. Ifa, R.G. Cooks, “Desorption Electrospray Ionization Mass Spectrometry for Lipid Characterization and Biological Tissue Imaging”, Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2011, 1811, 946 -960.
  103. T.A. Masterson, A.L. Dill, L.S. Eberlin, M.Mattarozzi, L. Cheng, S.D. W. Beck, F. Bianchi, R.G. Cooks, "Distinctive Glycerophospholipid Profiles of Human Seminoma and Adjacent Normal Tissues by Desorption Electrospray Ionization Imaging Mass Spectrometry", Journal of the American Society of Mass Spectrometry, 2011, 22, 1326-1333. 
  104. D.R. Ifa, A. Srimany, L.S. Eberlin, H.R. Naik, V. Bhat, R.G. Cooks, T. Pradeep, "Tissue Imprint Imaging by Desorption Electrospray Ionization Mass Spectrometry", Analytical Methods, 2011, 3, 1910-1912.
  105. A.L. Dill, L.S. Eberlin, A.B. Costa, C. Zheng, D.R. Ifa, L. Cheng, T.A. Masterson, M.O. Koch, O. Vitek, and R.G. Cooks, "Statistical Classification of Human Bladder Carcinomas using Ambient Ionization Imaging Mass Spectrometry", Chemistry-A European Journal, 2011, 17, 2897–2902.
  106. L.S. Eberlin, A.L. Dill, A.J. Golby, K.L. Ligon, J.M. Wiseman, R.G. Cooks, N.Y. R. Agar, "Discrimination of Human Astrocytoma Subtypes by Lipid Analysis using Desorption Electrospray Ionization Imaging Mass Spectrometry", Angewandte Chemie International Edition, 2010, 49, 5953-5956.
  107. L.S. Eerlin, R. Haddad, R.C.S. Neto, R.G. Cosso, D.R.J. Maia, A.O. Maldaner, J.J. Zacca, G.B. Sanvido, W. Romao, B.G. Vaz, D.R. Ifa, A.L. Dill, R.G. Cooks, M.N. Eberlin, “Instantaneous Chemical Profiles of Banknotes by Ambient Mass Spectrometry”, Analyst, 2010, 135, 2533-2539.
  108. A.L. Dill, L.S. Eberlin, C. Zheng; A.B. Costa; D.R. Ifa; L. Cheng; T.A. Masterson; M.O. Koch; O. Vitek; R.G. Cooks, "Statistical Differentiation of Renal Cell Carcinomas based on Lipidomic Analysis by Ambient Ionization Imaging Mass Spectrometry", Analytical and Bioanalytical Chemistry, 2010, 398, 2969-2978.
  109. R.G. Cooks, N.E. Manicke, A.L. Dill, D.R. Ifa, L.S. Eberlin, A.B. Costa, H. Wang, G. Huang, Z. Ouyang, "New ionization methods and miniature mass spectrometers in biomedicine: DESI imaging for cancer diagnostics and paper spray ionization for therapeutic drug monitoring", Faraday Discussions, 2010, 149, 247-267.
  110. L.S. Eberlin, A.L. Dill, A.B. Costa, D.R. Ifa, L.Cheng, T.Masterson, M.Koch, T.L. Ratliff, and R.G. Cooks, "Cholesterol Sulfate Imaging in Human Prostate Cancer Tissue by Desorption Electrospray Ionization Mass Spectrometry", Analytical Chemistry, 2010, 82, 3430-3434.
  111. L.S. Eberlin, D.R. Ifa, C.Wu, R.G. Cooks, "Three-Dimensional Visualization of Mouse Brain by Lipid Analysis Using Ambient Ionization Mass Spectrometry", Angewandte Chemie International Edition, 2010, 49, 873-876.
  112. A.L. Dill, L.S. Eberlin, D.R. Ifa and R.G. Cooks, "Perspectives in Imaging using Mass Spectrometry", Chemical Communications, 2010, 47, 2741 -2746.
  113. P. Albors, L.D. Slep, L.S. Eberlin, Y.E. Corilo, M.N. Eberlin, G. Bentez, M.E. Vela, R.C. Salvarezza and L.M. Baraldo, "From Monomers to Geometry-Constrained Molecules: One Step Further Toward Cyanide Bridged Wires", Inorganic Chemistry, 2009, 48, 11226-11235.
  114. L.S. Eberlin, P.V. Abdelnur, A. Passero, G.F. de Sa, R.J. Daroda, V. Souza and M.N. Eberlin, "Analysis of biodiesel and biodiesel–petrodiesel blends by high performance thin layer chromatography combined with easy ambient sonic-spray ionization mass spectrometry", Analyst, 2009, 134, 1652-1657.
  115. L.S. Eberlin, Y. Xia, H. Chen and R.G. Cooks, "Atmospheric Pressure Thermal Dissociation of Phospho- and Sulfopeptides", Journal of the American Society of Mass Spectrometry, 2008, 19, 1897-1905.
  116. P.V. Abdelnur, L.S. Eberlin, G.F. de Sá, V.Souza and M.N. Eberlin, "Single-Shot Biodiesel analysis: Nearly Instanteneous Typification and Quality Control Solely by Ambient Mass Spectrometry", Analytical Chemistry, 2008, 80, 7882-7886.
  117. M. Benassi, L.A.B. Moraes, L.G. Cabrini, L.C. Dias, A.M. Aguilar, G.A. Romeiro, L.S. Eberlin, M.N. Eberlin. "Recognition of cyclic, acyclic, exocyclic, spiro acetals via structurally diagnostic ion/molecule reactions with the (CH3)2N-C+=O acylium ion", Journal of Organic Chemistry, 2008, 73, 5549-5557.
  118. H. Chen, L.S. Eberlin, M. Nefliu, R. Augusti, R.G. Cooks, "Organic Reactions of Ionic Intermediates Promoted by Atmospheric-Pressure Thermal Activation", Angewandte Chemie International Edition, 2008, 47, 3422-3425.
  119. H. Chen, L.S. Eberlin and R.G. Cooks, "Neutral Fragment Mass Spectra after Ambient Thermal Dissociation of Peptide and Protein Ions", Journal of the American Chemical Society, 2007, 129, 5880-5886.
  120. D.R. Ifa, L. Gumaelius, L.S. Eberlin, N.E. Manicke and R.G. Cooks, "Forensic Analysis of Inks by Imaging Desorption Electrospray Ionization Mass Spectrometry", Analyst, 2007, 132, 461-467.
  121. A.H. Junior, L. Firn, A.J. Bortoluzzi, B.Szpoganicz, M.S. Silva, M.A. Novak, M.B. Neto, L.S. Eberlin, R.R. Catharino, M.N. Eberlin, C.Fernandes. "Solid state and solution characterization of a new dinuclear nickel (II) complex: The search for synthetic models for urease", Journal of Molecular Structure, 2006, 797, 154-164.
  122. R. Sparrapan, L.S. Eberlin, R. Haddad, R.G. Cooks, M.N. Eberlin and R. Augusti, "Ambient Eberlin Reactions via Desorption Electrospray Ionization", Journal of Mass Spectrometry, 2006, 41, 1242 -1264.
  123. R. Augusti, H. Chen, L.S. Eberlin, M. Nefliu and R.G. Cooks, "Atmospheric pressure Eberlin transacetalization reactions in the heterogeneous liquid/gas phase", International Journal of Mass Spectrometry, 2006, 253, 281-287.