About the Lab
The Functional and Cognitive Neurophysiology laboratory, led by Dr. Sameer Sheth, focuses on the study of human decision-making and cognition, as well as on the development of novel therapies for neuropsychiatric disorders. To accomplish these goals, we take a two-fold approach.
- First, we work with neurosurgical patients undergoing deep brain stimulation (DBS), epilepsy monitoring, and other procedures that require the placement of intracranial electrodes. We use single-neuron and field potential recordings as well as stimulation to understand the circuitry underlying complex cognitive functions such as controlled decision-making, memory formation, and emotional regulation.
- Second, we develop and refine neuromodulatory treatments for refractory neurological and psychiatric disorders such as obsessive-compulsive disorder (OCD), depression, and many others. These disorders often arise from dysfunction in the same circuits mentioned above.
Thus the two efforts advance synergistically, with a constant back-and-forth flow of ideas. Because of the multi-disciplinary nature of this work, the lab interacts closely with many other disciplines, including Neuroscience, Psychiatry, Neurology, Computational Science, Engineering, and others.
- Investigating DBS for Treatment-Resistant Depression
- Investigating the Neural Mechanisms Underlying Ad-Hoc Self-Programmability
- Investigating the Physiology of Controlled Decision-Making in Human Prefrontal Cortex
- Investigating Cortical and Basal Ganglia Networks Involved in Disorders of Mental Health
- Developing Novel Targets and Indications for Neuromodulation
View a listing of the Cognitive Neurophysiology Lab team members along with links to their bios.
Ask Me About My Research
Sameer Sheth, M.D., Ph.D., associate professor and vice-chair of clinical research in the department neurosurgery is joined by a special guest to demonstrate the importance of scientists and researchers talking with others about their work.
Our research projects and studies result in publications in PubMed and other scientific journals.
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Functional and Cognitive Neurophysiology Laboratory
BCM-Smith Medical Research Building
Houston, TX 77030