The ability to engineer synthetic genetic circuits in microorganisms has opened up new opportunities to use engineered microbes to diagnose and treat disease. We are using multiple platforms to sense intestinal inflammation in the human gut and secrete therapeutic proteins to prevent and treat a variety of human diseases. We are working on a non-invasive biosensor to non-invasively detect intestinal inflammation with the ultimate goal of providing an at home solution for patients to monitor gut health. We are also working on multiple therapeutic targets for gut-directed expression to treat rheumatoid arthritis, ulcerative colitis, and radiation induced intestinal injury.
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Ortiz-Velez L, Goodwin A, Schaefer L, Britton RA. Challenges and Pitfalls in the Engineering of Human Interleukin 22 (hIL-22) Secreting Lactobacillus reuteri. Front Bioeng Biotechnol. 2020;8:543. Published 2020 Jun 5. doi:10.3389/fbioe.2020.00543
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