Susan Hamilton Lab

Hamilton Lab Publications


Patricia Pate, Javier Mochca-Morales, Yuejin Wu, Jia-Zheng Zhang, George G. Rodney, Irina I. Serysheva, Barbara Y. Williams, Mark Anderson, and Susan L. Hamilton. Determinants for Calmodulin Binding on Voltage Dependent Ca2+ Channels. J. Biol. Chem., 2000; 275(50):39786-92. PMID: 11005820

Rodney, G.G., Krol, J., Williams, B.Y., Beckingham, K. and Hamilton, S. L. The Carboxy-Terminal Calcium Binding Sites of Calmodulin Control Calmodulin’s Switch from and Activator to an Inhibitor of RYR1. Biochemistry, 2001; 40:12430-5. PMID: 11591164

Tang, W., Ingalls, C., Durham, W., Snider, J., Reid, M., Wu, G-Y, Matzuk, M.M., and Hamilton, S.L. Altered Excitation-Contraction Coupling with FKBP12 Skeletal Muscle Specific Deficiency. FASEB J., 2004 Oct; 18(13):1597-9. PMID: 15289441

Serysheva, I.I., Hamilton, S.L., Chiu, W., and Ludtke, S.J. Structure of Ca2+ Release Channel at 14-Å Resolution. J. Molecular Biology, 2005 Jan 21; 345(3):427-31. PMCID: PMC2978512

Chelu, M. G., Goonasekera, S. A., Durham, W. J., Tang, W., Lueck, J. D., Riehl, J., Pessah, I. N., Zhang, P., Bhattacharjee, M. B., Dirksen, R. T., and Hamilton, S. L. Heat- and Anesthesia-Induced Malignant Hyperthermia in an RyR1 Knock-in Mouse. FASEB J. , 2006;20(2):329-330. PMID: 16284304

Kannankeril, P. J., Goonasekera, S.A., Mitchell, B.M., Chelu, M.G., Zhang, W., Kearney, D.L., De Biasi, M., Pautler, R.G., Roden, D.M., Taffet, G.E., Dirksen, R.T., Anderson, M.E., and Hamilton, S.L. Mice with the R176Q Cardiac Ryanodine Receptor Mutation Exhibit Catecholamine-Induced Ventricular Tachycardia and Mild Cardiomyopathy. Proc. Natl. Acad. Sci. USA, 2006; 103(32):12179-84. PMCID: PMC1567715

Long, C., Cook, L.G., Hamilton, S.L., Wu, G-Y., and Mitchell, B.M. FK506 Binding Protein 12/12.6 Depletion Increases Endothelial Nitric Oxide Synthase Threonine 495 Phosphorylation and Blood Pressure. Hypertension Jan 2007; 49(3): 569- 576. PMID: 17261647

Hoeffer, C.A., Tang, W., Santillan, A., Patterson, R.J., Martinez, L. A., Tejada-Simon, M. V., Hamilton, S.L. and Klann, E. Removal of FKBP12 Enhances mTOR-Raptor Interactions LTP, Memory, and Perseverance/Repetitive Behavior. 2008; Neuron 60(5):832-45 PMCID: PMC2630531

Serysheva, I., Ludke, S.J., Baker, M.L., Cong, Y., Topf, M., Sali, A., Hamilton, S.L. and Chiu, W. Subnanometer Resolution Cryo-EM Based Domain Models for the Cytoplasmic Region of Skeletal Muscle RyR Channel. 2008; Proc. Natl. Acad. Sci. USA 105(28):9610-15. PMCID: PMC2474495

Durham WJ, Aracena-Parks P, Long C, Rossi AE, Goonasekera SA, Boncompagni S, Galvan DL, Gilman CP, Baker MR, Shirokova N, Protasi F, Dirksen R, Hamilton SL. RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice. 2008; Cell 133(1):53-65. PMCID: PMC2366094

Fallon, J.L., Baker, M., Xiong, L., Loy, R. E., Yang, G., Dirksen, R.T., Hamilton, S.L., and A. Quiocho, F.A., Crystal Structure of Dimeric Cardiac L-Type Calcium Channel Regulatory Domains Bridged by Ca2+Calmodulin. Proc. Natl. Acad. Sci. USA, 2009; 106(13):5135-40. PMCID: PMC2654391

Halling, D.B., Black, D.J., Yang, G., Fallon, J.L., Quiocho, F. A., Pedersen, S. E., and Hamilton S.L. Determinants in CaV1 Channels that Regulate the Ca2+ Sensitivity of Bound Calmodulin. J. Biol. Chem, 2009 July 284 (30): 20041-51. PMCID: PMC2740430

Lanner, J., Georgiou, D.K., Dagnino-Acosta, A., 1Ainbinder, A., Cheng, Q., Joshi, A., Chen, Z., Yarotskyy,V., Oakes, J., Lee, C.S., Monroe, T., Santillan, A., Dong, K., Goodyear, L., Ismailov, I., Rodney, G.G., Dirksen, R., and Hamilton, S. AICAR Prevents Heat Induced Malignant Hyperthermia in RyR1 Mutant Mice Independent of AMPK Activation. Nature Medicine,18: 252-9, 2012 PMCID: PMC3274651.

Knoblauch,M., Dagnino-Acosta, A, Hamilton, S.L. Mice with RyR1 mutation (Y524S) undergo hypermetabolic response to simvastatin Skeletal Muscle 2013, 3:22 (3 September 2013).

Lee, C.S., Georgiou, D., Dagnino-Acosta, A., Xu,J., Ismailov, I., Knoblauch, M., Monroe, T., Ji, R., Hanna,A., Joshi, A. Long, C., Oakes, J., Tran,T., Corona,B., Lorca,S., Ingalls, C., Narkar, V., Lanner,J.,Bayle,J., Durham, W. and Hamilton, S. Ligands for FKBP12 Increase Ca2+ Influx and Protein Synthesis to Improve Skeletal Muscle Function. J. Biol. Chem. published 22 July 2014, 10.1074/jbc.M114.5862 PMCID: PMC4162161

Xiong, L., Kleerekoper, Q.K., He, R., Putkey, J. and Hamilton, S.L. Sites on calmodulin that interact with the C-terminal tail of Cav1.2 channel. J. Biol. Chem., 2005 Feb 25;280(8):7070-9.

Lee CS, Dagnino-Acosta A, Yarotskyy V, Hanna A, Lyfenko A, Knoblauch M, Georgiou DK, Poché RA, Swank MW, Long C, Ismailov II, Lanner J, Tran T, Dong K, Rodney GG, Dickinson ME, Beeton C, Zhang P, Dirksen RT, Hamilton SL. Ca2+ permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca2+ signaling to sustain muscle function. Skelet Muscle. 2015 Jan 29;5:4. doi: 10.1186/s13395-014-0027-1. eCollection 2015. PMCID: PMC4340672.

Georgiou. D. K., Dagnini-Acosta, A., Lee, C..S., Griffin, D.M., Wang, H., Lagor, W. R., Pautler, R.G., Dirksen, R.T., and Hamilton, S.L. Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism. J. Biol. Chem. jbc.M115.643544. First Published on August 5, 2015, doi:10.1074/jbc.M115.643544. PMCID: PMC4583036