Research

Publications: Center for Lysosome Regulation and Signaling Research

Master
Content

Gedam, M., Comerota, M.M., Propson, N.E., Chen, T., Jin, F., Wang, M.C., and Zheng, H. Complement C3aR depletion reverses HIF-1α-induced metabolic impairment and enhances microglial response to Aβ pathology. J. Clin. Invest. 2023; 133(12):e167501. PMCID: PMC10266793.

Comerota, M., Gedam, M., Xiong, W., Jin, F., Deng, L., Wang, M.C., Wang, J., and Zheng, H. Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s disease. Mol. Neurodegen. 2023;18(1):56. PMCID: PMC10426131.

Nguyen, Q. Wood, C.A., Kim, P.J, and Jankowsky, J.L. TMEM106B T186S coding variant increases neurite arborization and synaptic density in primary neurons. Front. Neurosci. 17:1275959 (2023) PMCID: PMC10603297

Zhang, T., Pang, W., Feng, T., Guo, J., Wu, K., Nunez Santos, M., Arthanarisami, A., Nana, A.L., Nguyen, Q., Kim, P.J., Jankowsky, J.L., Seeley, W.L., Hu, F. TMEM106B regulates microglial proliferation and survival in response to demyelination. Sci Adv. (in press). PMID: 37146150

Edwards, G.A. III, Wood, C.A., He, Y., Nguyen, Q., Kim, P.J., Gomez-Gutierrez, R., Park, K.-W., Xu, Y., Zurhellen, C., Al-Ramahi, I., and Jankowsky, J.L. TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy. Acta Neuropathol. 147:61 10.1007/s00401-024-02701-5 (2024) PMID: 38526616

Wang, B., Martini-Stoica, H., Qi, C., Lu, T.-C., Wang, S., Xiong, W., Qi, Y., Sardiello, M., Li, H., and Zheng, H. TFEB-vacuolar ATPase signaling regulates lysosomal function and microglia activation in tauopathy. Nat. Neurosci. 2024; 27, 48-62. PMCID: PMC9934527.

Xu, Y., Propson, N.E., Du, S., Xiong, W., and Zheng, H. Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading. Proc. Natl. Acad. Sci. USA 2021; 118(27): e2023418118. PMCID: 8271658

Xu, Y., Du, S., Marsh, J.A., Horie, K., Sato, C., Ballabio, A., Karch, C.M., Holtzman, D.M., and Zheng, H. TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading. Mol. Psych. 2020; https://doi.org/10.1038/s41380-020-0738-0. PMCID: 7609570

Xu, Y., Zhang, S., and Zheng, H. The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein Tau). Autophagy 2019; 15(4): 583-98. PMCID: 6526869

Holt MV, Wang T, Young NL. High-Throughput Quantitative Top-Down Proteomics: Histone H4. J Am Soc Mass Spectrom. 2019 Dec;30(12):2548-2560. doi: 10.1007/s13361-019-02350-z. Epub 2019 Nov 18. PMID: 31741267

Pal R, Xiong Y, Sardiello. Abnormal glycogen storage in tuberous sclerosis complex caused by impairment of mTORC1-dependent and -independent signaling pathways. M.Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2977-2986. doi: 10.1073/pnas.1812943116. Epub 2019 Feb 6. PMID: 30728291

Martini-Stoica, H., Cole, A.L., Swartzlander, D.B., Chen, F., Wan, Y.-W., Bajaj, L., Bader, D.A., Lee, V.M.-Y., Trojankowski, J.Q., Liu, Z., Sardiello, M., and Zheng, H. TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. J. Exp. Med. 2018; 215(9): 2355-77. PMCID: 6122971

Jiang T, Hoover ME, Holt MV, Freitas MA, Marshall AG, Young NL. Middle-Down Characterization of the Cell Cycle Dependence of Histone H4 Posttranslational Modifications and Proteoforms. Proteomics. 2018 Jun;18(11):e1700442. doi: 10.1002/pmic.201700442. PMID: 29667342

di Ronza A, Bajaj L, Sharma J, Sanagasetti D, Lotfi P, Adamski CJ, Collette J, Palmieri M, Amawi A, Popp L, Chang KT, Meschini MC, Leung HE, Segatori L, Simonati A, Sifers RN, Santorelli FM, Sardiello M. CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosomebiogenesis. Nat Cell Biol. 2018 Dec;20(12):1370-1377. doi: 10.1038/s41556-018-0228-7. Epub 2018 Nov 5. PMID: 30397314

Pal R, Palmieri M, Chaudhury A, Klisch TJ, di Ronza A, Neilson JR, Rodney GG, Sardiello M. Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction. Nat Commun. 2018 Oct 19;9(1):4351. doi: 10.1038/s41467-018-06844-4. PMID: 30341294