Discoveries to Disease
In the Texas Medical Center, there are no boundaries separating research and clinical care. Basic, translational and clinical researchers share buildings with clinical care providers and labs are mere steps away from clinics and hospitals. Whether working at the molecular, cellular or organismal level, our researchers maintain perspective on how their work may impact human disease and health.
BCM’s contributions to advancing the study of genetics and genomics have included:
- Determining the sequences of chromosomes 3, 12 and part of X as part of their role as one of three centers to complete the Human Genome Project
- Leading sequencing of many animal genomes, including the mouse, rat, fruit fly, rhesus monkey, honey bee, sea urchin, marmoset, orangutan, and cow
- Describing the first case of uniparental disomy, in which a child receives both copies of a gene from one parent
- Pioneering DNA microarray technology that streamlines diagnosis of genetic and chromosomal diseases
- Discovering the gene that causes Rett syndrome, a post-natal genetic disorder that affects mainly girls, and many other neurodevelopmental and neurological diseases
- Identifying new genetic variants in a cartilage protein that results in a lethal form of the brittle bone disease called osteogenesis imperfecta, and many other skeletal disorders
- Sequencing and annotating the first personalized genome sequence, that of Dr. James Watson, Nobel laureate who described DNA’s double helix
- Conducting the first successful surgery on the human genome.
As you begin your career in research it is impossible to predict where your investigations will lead. Therefore, it is essential to have access to diverse resources. This includes not only equipment, but experienced individuals available to help you identify the resources you need and master their use.