Email

chetan.rajpurohit@bcm.edu

Positions

Postdoctoral Associate

Huffington Center on Aging
Baylor College of Medicine

Addresses

One Baylor Plaza (Lab)

Houston
United States

Education

PhD from CSIR-Indian Institute of Toxicology Research

10/2019 - Lucknow, Uttar Pradesh India

MSc from Dayanand College Ajmer

05/2012 - Ajmer, Rajasthan India

Professional Statement

My research at Hui Zheng Lab focuses on understanding the cellular mechanisms underlying Alzheimer's disease (AD) using transgenic human induced pluripotent stem cell (iPSC)-derived brain cells associated with the disease. Specifically, we have differentiated iPSCs with R406W and P301S mutations in the microtubule-associated protein tau into cortical neurons and astrocytes to study the downstream targets of transcription factor EB (TFEB). TFEB is a master regulator of lysosomal biogenesis and autophagy pathways. My goal is to investigate how TFEB activity manages APP and tau aggregation in iPSC-derived neurons and how it alters their characteristics.