Shixia Huang, Ph.D.
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Shixia Huang, Ph.D.
Associate Professor
Positions
- Associate Professor
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Mol & Cell Biology
Baylor College of Medicine
- Director, Antibody-Based Proteomics Core
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Advanced Technology Cores
Baylor College of Medicine
Houston, Texas United States
- Associate Professor
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Education, Innovation & Technology
Baylor College of Medicine
- Faculty Senator
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Baylor College of Medicine
- Chair, Research Subcommittee
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Inclusion and Excellence Council
Baylor College of Medicine
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
- DEI Council Member
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Association of Biomolecular Resource Facilities
Education
- PhD from Michigan State University
- East Lansing, Michigan United States
- Genetics
- Postdoctoral Fellowship at National Cancer Institute
- Bethesda, Maryland United States
- Postdoctoral Fellowship at Memorial Sloan-Kettering Cancer Center
- New York, New York United States
- MS from Yangzhou University
- Yangzhou, Jiangsu China, People's Rep
- Infectious Disease & Preventive Veterinary Medicine
- BS from Hunan Agricultural University
- Changsha, Hunan China, People's Rep
- Veterinary Medicine
Professional Statement
Developing high-throughput antibody-based proteomic platforms for protein biomarker discovery and validation, especially for low abundance regulatory proteins and their activation states such as phosphorylation and histone translational modifications.Combining my advance technology expertise and passion in education to build biotechnology education programs with a focus on diversity and inclusion.
Websites
The Antibody-based Proteomics Core provides cutting-edge antibody-based proteomic platforms for both validation and protein biomarker discovery, particularly for low abundance regulatory proteins and activation states of proteins with phosphorylated antibodies.
Selected Publications
- Huang S, Li Y, Chen Y, Podsypanina K, Chamorro M, Olshen AB, Desai KV, Tann A, Petersen D, Green JE, Varmus HE "Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice.." Genome Biol..2005;6(10):R84. Pubmed PMID: 16207355
- Huang S, Flanders KC, Roberts AB "Characterization of the mouse Smad1 gene and its expression pattern in adult mouse tissues.." Gene.2000/November27;258(41276):43-53. Pubmed PMID: 11111041
- Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X, Rowlands T, Egeblad M, Cowin P, Werb Z, Tan LK, Rosen JM, Varmus HE "Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.." Proc. Natl. Acad. Sci. U.S.A..2003/December23;100(26):15853-8. Pubmed PMID: 14668450
- Lu, H.-Y., Xiong, j., Perera, D. N., Rajapakshe, K., Wang, X., Costello M., Holloway K. R., Ramos, C., Grimm, S. L., Wulfkuhle, J., Coarfa, C., Edwards, D. P., Zhu, M. X., and Huang, S. "High-throughput Evaluation of Metabolic Activities Using Reverse Phase Protein Array (RPPA) Technology." Book chapter in: Tong, Q., 1st ed. Neuronal Signaling in Metabolism.2021/June;1st Edition:25.
- Coarfa C, Grimm SL, Rajapakshe K, Perera D, Lu HY, Wang X, Christensen KR, Mo Q, Edwards DP, Huang S. "Reverse-Phase Protein Array: Technology, Application, Data Processing, and Integration." J Biomol Tech.. 2021 April ; 32 (1): 15-29. Pubmed PMID: 34025221
- Dong J, Huang S, Caikovski M, Ji S, McGrath A, Custorio MG, Creighton CJ, Maliakkal P, Bogoslovskaia E, Du Z, Zhang X, Lewis MT, Sablitzky F, Brisken C, Li Y "ID4 regulates mammary gland development by suppressing p38MAPK activity.." Development. 2011 December ; 138 (23): 5247-56. Pubmed PMID: 22069192
- Huang S, Chen Y, Podsypanina K, Li Y "Comparison of expression profiles of metastatic versus primary mammary tumors in MMTV-Wnt-1 and MMTV-Neu transgenic mice.." Neoplasia. 2008 February ; 10 (2): 118-24. Pubmed PMID: 18283333
- Huang S, Tang B, Usoskin D, Lechleider RJ, Jamin SP, Li C, Anzano MA, Ebendal T, Deng C, Roberts AB "Conditional knockout of the Smad1 gene.." Genesis. 2002 February ; 32 (2): 76-9. Pubmed PMID: 11857782
Projects
- Program Director: Baylor College of Medicine Biotechnology Research Incubator for TEachers (BCM-BRITE)
- Baylor College of Medicine
- Houston, Texas
- To educate the next generation thinkers and problem solvers in secondary school, science teachers’ passion and understanding in bioscience research and technology are critically important. The objective of BCM-BRITE program is a professional development experience for passionate educators. Teachers are paired with scientists for a scientific immersion experience, translating into high-quality classroom experiences for their students and sustaining STEMM (Science Technology Engineering, Mathematics, and Medicine) education at a rigorous level. Goals: 1. Improve the quality of STEMM education through providing intensive two-weeks hands-on technology-research immersion opportunities as a professional training program to middle/high school teachers. 2) Enhance teachers’ understanding of rigorous research and biotechnology literacy in STEMM. 3) Facilitate students’ STEMM education through evaluation and following-up with BCM-BRITE teachers’ success and their lesson plans and with scientist mentor's visits to their classrooms/career fairs to share careers in STEMM and scientific exploration.
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