Yingbin Fu, Ph.D.
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Yingbin Fu, Ph.D.
Professor - Sarah Campbell Blaffer Endowed Chair
Positions
- Professor - Sarah Campbell Blaffer Endowed Chair
-
Ophthalmology
Baylor College of Medicine
Houston, TX US
Addresses
- Neurosensory Center (Office)
-
Room: NEUR-C 506
Houston, TX 77030
United States
Education
- PhD from Michigan State University
- 05/1998 - Lansing, Michigan United States
- Biochemistry
- Postdoctoral Fellowship at Johns Hopkins University School of Medicine
- 05/2006 - Baltimore, Maryland United States
- Visual Neurophysiology
- BS from Peking University
- 05/1991 - Beijing, China
- Biochemistry
Honors & Awards
- Audacious Goals Challenge Prize
- https://rebrand.ly/nih-award1
- National Eye Institute (02/2013)
- The Helen Juanita Reed Award for Macular Degeneration Research
- BrightFocus Foundation (04/2018)
- 2021 NEI Audacious Goals Initiative Grant Award
- https://www.nei.nih.gov/about/news-and-events/news/learning-how-transplanted-neurons-fit-0
- National Eye Institute (09/2021 - 08/2026)
Professional Interests
- Angiogenesis, cholesterol metabolism, and inflammation
- Age-related macular degeneration, retinal degeneration
- Gene therapy
Professional Statement
The Fu lab is interested in using the visual system to study angiogenesis, cholesterol metabolism, inflammation, and the biological mechanisms underlying various types of neurodegeneration, and to develop innovative treatment strategies. The lab has made significant contributions toward the understanding of the role of a multifunctional serine protease HTRA1 in age-related macular degeneration (AMD), the pathogenesis of polypoidal choroidal vasculopathy (PCV, a variant of wet type AMD), and the role of cone opsins in cone photoreceptor degeneration. Our recent research includes the following projects: 1) the role of the apolipoprotein-A-I binding protein (AIBP) in AMD; 2) the mechanism and treatment strategies for anti-VEGF resistance in wet AMD; 3) lipid metabolism and AMD, and 4) generating novel models of photoreceptor degeneration for regenerative cell therapy (NIH U24 project). Our recent studies have identified a mechanism for anti-VEGF resistance in wet AMD and developed the first potential AIBP/apoa-I/anti-VEGF combination treatment to overcome anti-VEGF resistance (PCT/IB2021/055463 patent pending).The PI has won the National Institute of Health/National Eye Institute Audacious Goals Challenge Awards (https://rebrand.ly/nih-award1; https://rebrand.ly/nei-award1). We place emphasis in Translational Research-- discovering disease mechanisms and developing innovative treatment strategies. Due to the translational nature of our research, students and postdocs will have good employment opportunities in both academia and industry. With diverse research projects (from basic to translational), there is ample opportunity for incoming students. We welcome rotation students!The Fu lab currently has one position open for a postdoc/research associate. Highly motivated candidates who are interested in addressing major health challenges facing our modern society are encouraged to apply at: https://jobs.bcm.edu/job/Houston-Postdoctoral-Associate-Texa/1004294800/.
Websites
Selected Publications
- Kumar S, Nakashizuka H, Jones A, Lambert A, Zhao X, Shen M, Parker M, Wang S, Berriochoa Z, Fnu A, VanBeuge S, Chévez-Barrios P, Tso M, Rainier J, Fu Y. "Proteolytic Degradation and Inflammation Play Critical Roles in Polypoidal Choroidal Vasculopathy." Am J Pathol.. 2017 Dec 20;187(12):2841-2857. Pubmed PMID: 28941979
- Zhang T, Cao LH, Kumar S, Enemchukwu NO, Zhang N, Lambert A, Zhao X, Jones A, Wang S, Dennis EM, Fnu A, Ham S, Rainier J, Yau KW, Fu Y "Dimerization of visual pigments in vivo.." Proc Natl Acad Sci U S A.. 2016 Jul 26; Pubmed PMID: 27462111
- Zhang T, Enemchukwu NO, Jones A, Wang S, Dennis E, Watt CB, Pugh EN Jr, Fu Y. "Genetic deletion of S-opsin prevents rapid cone degeneration in a mouse model of Leber congenital amaurosis.." Hum Mol Genet.. 2015 Mar 15;24(6):1755-63. Pubmed PMID: 25416279
- Jones A, Kumar S, Zhang N, Tong Z, Yang JH, Watt C, Anderson J, Amrita, Fillerup H, McCloskey M, Luo L, Yang Z, Ambati B, Marc R, Oka C, Zhang K, Fu Y. "Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice.." Proc Natl Acad Sci U S A.. 2011 Aug 30;108(35):14578-83. Pubmed PMID: 21844367
- Zhang T, Zhang N, Baehr W, Fu Y. "Cone opsin determines the time course of cone photoreceptor degeneration in Leber congenital amaurosis.." Proc Natl Acad Sci U S A.. 2014 May 24;108(21):8879-84. Pubmed PMID: 21555576
- Fu Y, Kefalov V, Luo DG, Xue T, Yau KW. "Quantal noise from human red cone pigment.." Nat Neurosci.. 2008 May;11(5):565-71. Pubmed PMID: 18425122
- Kumar S, Berriochoa Z, Ambati BK, Fu Y. "Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium.." Invest Ophthalmol Vis Sci.. 2014 May 22;55(6):3482-50. Pubmed PMID: 24854852
- Zhu L, Parker M, Enemchukwu N, Shen M, Zhang G, Yan Q, Handa J, Fang L, and Fu Y "Combination of apolipoprotein-A-I/apolipoprotein-A-I binding protein and anti-VEGF treatment overcomes anti-VEGF resistance in choroidal neovascularization in mice." 2020 Jul 16;3(1):386. Pubmed PMID: 32678293
- Xu H, Enemchukwu N, Zhong X, Zhang O, and Fu Y "Deletion of M-opsin prevents “M cone” degeneration in a mouse model of Leber congenital amaurosis." Am J Pathol .. 2020 May;190(5):1059-1067. Pubmed PMID: 32084365
- Xu H, Jin N, Chuang J-Z, Zhang Zhao, Zhong X, Zhang Zhijing, Sung C-H, Ribelayga CP, Fu Y "Visual pigment–deficient cones survive and mediate visual signaling despite the lack of outer segments." Proc Natl Acad Sci U S A.. 2022 Mar 1;119(9) Pubmed PMID: 35197287
- a. Pan, Y., Fu, Y., Baird, P.N., Guymer, R.H., Das, T., and Iwata, T. "Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration." 2022; Pubmed PMID: 36581531
- d. Zhang, Z., Shen, M. M. & Fu, Y. "Combination of AIBP, apoA-I, and Aflibercept Overcomes Anti-VEGF Resistance in Neovascular AMD by Inhibiting Arteriolar Choroidal Neovascularization." 2022;63(12):2. Pubmed PMID: 36318195
Memberships
- Association for Research in Vision and Ophthalmology
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