Jason Mills Lab

Mills Lab Publications


Willet SG, Thanintorn N, McNeill H, Huh SH, Ornitz DM, Huh WJ, Hoft SG, DiPaolo RJ, Mills JC. SOX9 governs gastric mucous neck cell identity and is required for injury-induced metaplasia. Cell Mol Gastroenterol Hepatol. 2023 Jun 1:S2352-345X(23)00106-6. doi: 10.1016/j.jcmgh.2023.05.009. PMID: 37270061. 

Huang XZ, Pang MJ, Li JY, Chen HY, Sun JX, Song YX, Ni HJ, Ye SY, Bai S, Li TH, Wang XY, Lu JY, Yang JJ, Sun X, Mills JC*, Miao ZF, Wang ZN. Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis. Nat Commun. 2023;14:822. PMID: 36788228; PMCID: PMC9929081. *Co-corresponding author 

Sáenz JB, Vargas N, Cho CJ, Mills JC. Regulation of the double-stranded RNA response through ADAR1 licenses reprogramming in gastric epithelium. JCI Insight. 2022. 7:e153511. PMID: 35132959; PMCID: PMC8855806 

Cho CJ, Park D, Mills JC. ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis. Am J Physiol Gastrointest Liver Physiol. 2022. 322:G49-G65. PMID: 34816763; PMCID: PMC8698547 

Brown JW, Cho CJ, Mills JC. Paligenosis: Cellular Remodeling During Tissue Repair. Annu Rev Physiol. 2022. 84:461-483. PMID: 34705482; PMCID: PMC8831470 (review) 

Radyk MD, Spatz LB, Peña BL, Brown JW, Burclaff J, Cho CJ, Yan Chien-Cheng Shih K, Fitzpatrick JAJ. Mills JC. ATF3 induces RAB7 to govern autodegradation in paligenosis, a conserved cell plasticity program. EMBO Reports 2021. 22:e51806. PMID: 34309175; PMCID: PMC8419698 

Jin RU, Brown JW, Li QK, Bayguinov PO, Wang JS, Whelan SPJ, Fitzpatrick JAJ, Meeker AK, Mills JC. Tropism of SARS-CoV-2 for Barrett's Esophagus may Increase Susceptibility to Developing COVID-19. Gastroenterology 2021160:2165-2168. PMID: 33484686; PMCID: PMC7816599 

Miao ZF, Sun JX, Adkins-Threats M, Pang MJ, Zhao JH, Wang X, Tang KW, Wang ZN, Mills JC. DDIT4 licenses only healthy cells to proliferate during injury-induced metaplasia. Gastroenterology 2021. 160:260-271. PMID: 32956680; PMCID: PMC7857017  

Miao ZF, Lewis MA, Cho CJ, Adkins-Threats M, Park D, Brown JW, Sun JX, Burclaff JR, Kennedy S, Lu J, Mahar M, Vietor I, Huber LA, Davidson NO, Cavalli V, Rubin DC, Wang ZN, Mills JC. A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle. Dev Cell. 2020 55:178-194. PMID: 32768422; PMCID: PMC7606764 (Selected for Cover

Miao ZF, Adkins-Threats M, Burclaff JR, Osaki LH, Sun JX, Kefalov Y, He Z, Wang ZN, Mills JC. A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation. Cell Stem Cell. 2020 26:910-925 PMID: 32243780; PMCID: PMC7275895. 

Burclaff J, Willet SG, Sáenz JB, Mills JC. Proliferation and differentiation of gastric mucous neck and chief cells during homeostasis and injury-induced metaplasia. Gastroenterology 2020 158:598-609 PMID: 31589873; PMCID: PMC7010566 

Osaki LH, Bockerstett KA, Wong CF, Ford EL, Madison BB, DiPaolo RJ, Mills JC. Interferon-γ directly induces gastric epithelial cell death and is required for progression to metaplasia. J Pathol 2019 247: 513-523 PMID: 30511397; PMCID: PMC6402979 

Sáenz JB, Vargas N, Mills JC. Tropism for Spasmolytic Polypeptide-Expressing Metaplasia Allows Helicobacter pylori to Expand its Intragastric Niche. Gastroenterology 2019 156:160-174. PMID: 30287170; PMCID: PMC6309511 

Burclaff J, Mills JC: Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine. Dis Model Mech. 2018 11(9). PMID: 30171151; PMCID: 6177008 (review) 

Burclaff J, Mills JC. Plasticity of differentiated cells in wound repair and tumorigenesis, part I: stomach and pancreas. Dis Model Mech. 2018 11(7). PMID: 30037967; PMCID: PMC6078397 (review) 

Sáenz JB, Mills JC. Acid and the basis for cellular plasticity and reprogramming in gastric repair and cancer. Nat Rev Gastroenterol Hepatol. 2018 15:257-273 PMID:  29463907; PMCID: PMC6016373 (review) 

Radyk MD, Burclaff J, Willet SG, Mills JC. Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief Cells. Gastroenterology 2018 154:839-843.e2. PMID: 29248442; PMCID: PMC5847468 (Commentary in Gastroenterology. 2018 Mar;154:801-803; Faculty of 1000 Prime article) 

Burclaff J, Osaki LH, Liu D, Goldenring JR, Mills JC. Targeted Apoptosis of Parietal Cells is Insufficient to Induce Metaplasia in Stomach. Gastroenterology. 2017; 152:762-766. PMID: 27932312; PMCID: PMC5391042 

Willet SG, Lewis MA, Miao ZF, Liu D, Radyk MD, Cunningham RL, Burclaff J, Sibbel G, Lo HG, Blanc V, Davidson NO, Wang ZN, Mills JC. Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis. EMBO J 2018 37: e98311. PMID: 29467218; PMCID: PMC5881627 (Commentary in EMBO J. 2018 37:7) 

Lo HG, Jin RU, Sibbel G, Liu D, Karki A, Joens MS, Madison BB, Zhang B, Blanc V, Fitzpatrick JA, Davidson NO, Konieczny SF, Mills JC. A single transcription factor is sufficient to induce and maintain secretory cell architecture. Genes Dev. 2017; 31:154-171. PMID: 28174210; PMCID: PMC5322730  

Willet SG, Mills JC: Stomach Organ and Cell Lineage Differentiation: From Embryogenesis to Adult Homeostasis. Cell Mol Gastroenterol Hepatol; 2016:2:546-559. PMID: 27642625; PMC5025260 

Sáenz JB, Burclaff J, Mills JC: Modeling Murine Gastric Metaplasia through Tamoxifen-Induced Acute Parietal Cell Loss. Methods Mol Biol; 2016;1422:329-339. PMID: 27246044; PMCID: PMC5221414 

Mills JC, Sansom OJ. Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract. Sci Signaling; 2015;8(385):re8. PMID: 26175494; PMC4858190 (review) 

Khurana SS, Riehl TE, Moore BD, Fassan M, Rugge M, Romero-Gallo J, Noto J, Peek RM, Stenson WF, Mills JC. The hyaluronic acid receptor CD44 coordinates normal and metaplastic gastric epithelial progenitor cell proliferation. J Biol Chem; 2013;288:16085-16097; PMID: 23589310; PMCID: PMC3668764 (Chosen for Cover Illustration)  

Moore BD, Jin RU, Lo HY, Jung M, Wang H, Battle MA, Wolheim CB, Urano F, Mills JC. Transcriptional regulation of X-Box-Binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4α) is vital to β-cell function. J Biol Chem; 2016; 291:6146-6157. PMID: 26792861; PMCID: PMC4813565 

Jin RU, Mills JC. RAB26 coordinates lysosome traffic and mitochondrial localization. J Cell Sci; 2014; 127:1018-1023. PMID: 24413166; PMCID: PMC3937772 (This article featured by editors in “In This Issue”)  

Stange DE, Koo B-K, Huch M, Sibbel G, Basak O, Lyubimova A, Kujala P, Bartfeld S, Koster J, Geahlen JH, Peters PJ, van Es JH, van de Wetering M, Mills JC, Clevers H. Differentiated Troy+ chief cells act as “reserve” stem cells to generate all lineages of the stomach epithelium. Cell; 2013;155:357-368. PMID: 24120136; PMCID: PMC4094146 

Mills JC, Taghert PH: Scaling Factors: transcription factors regulating subcellular domains. Bioessays; 2012;34:10-6. 3692000 PMID: 22028036; PMCID: PMC3692000 (review)