Katherine King Lab



Kain BN, Tran BT, Luna PN, Cao R, Le DT, Florez MA, Maneix L, Toups JD, Morales-Mantilla DE, Koh S, Han H, Jaksik R, Huang Y, Catic A, Shaw CA, King KY. (2023) Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models. iScience online ahead of print. https://doi.org/10.1016/j.isci.2023.

Figueroa M, Ma H, Alfayez M, Morales-Mantilla D, Wang F, Lu Y, Estecia M, King KY, Kleinerman E, Moghaddam S, Daver N, Andreeff M, Konopleva M, DiNardo C, and Chandra J. (2023) Cigarette smoke exposure accelerates AML progression in FLT3-ITD models. Blood Advances. Online ahead of print. PMID: 37486624.

Le DT, Florez MA, Kus P, Tran BT, Kain B, Zhu Y, Christensen K, Jain A, Malovannaya A, and King KY. (2023) BATF2 promotes HSC myeloid differentiation by amplifying IFN response mediators during chronic infection. iScience 26(2):106059 PMID:36824275.

Read JA, Rouce RH, Mo F, Mamonkin M, King KY. (2023) Apoptosis of HSCs contributes to bone marrow suppression following CAR-T therapy. Transplantation and Cellular Therapy. 29(3):165.e1-165.e7. PMID: 36592718.

Morales-Mantilla DE, King KY. (2022) FGD5 marks a subpopulation of hematopoietic stem and progenitor cells that resist interferon-gamma-mediated differentiation. Exp. Hematol. 112-113:35-43. PMID: 35768035.

Bogeska R, Mikecin AM, Kaschutnig P, … King KY, Frenette PS, Rieger MA, Milsom MD. (2022) Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging. Cell Stem Cell. 29(8):1273-1284. PMID: 35858618

Zhang C, Ostrander E, Kukhar O, Mallaney C, Sun J, Haussler E, Celik H, Koh W, King KY, Gontarz P, and Challen G. (2022) Txnip enhances fitness of Dnmt3a-mutant hematopoietic stem cells via p21. Blood Cancer Discovery. 3(3):220-239. PMID: 35394496.

Yan H, Walker FC, Ali A, Han H, Tan L, Veillon L, Lorenzi PL, Baldridge MT, and King KY. (2022) The bacterial microbiota regulates normal hematopoiesis via metabolite-induced type 1 interferon signaling. Blood Advances. 6(6):1754-65. PMID: 35143611.

Morales-Mantilla DE, Kain B, Le D, Flores AR, Paust S, and King KY. (2022) Hematopoietic stem and progenitor cells improve survival from sepsis by boosting immunomodulatory cells. eLife 11:e74561. PMID: 35166205.

Chen Y, Talukder R, Merritt BY, King KY, Kimmel M, Rivero G, and Sosa R. (2021) Genomic trajectory in leukemogenesis of myeloproliferative neoplasms: a case report. BMC Med Genomics. 14(1):137. PMID: 34022887.

Hormaechea-Agulla D, Matatall K, Le DT, Kain B, Long X, Kus P, Jaksik R, Challen GA, Kimmel M, and King KY. (2021) Chronic infection drives Dnmt3a-loss of function clonal hematopoiesis via IFNg signaling. Cell Stem Cell. 28(8):1428-1442. PMID: 33743191.

Demerdash Y, Kain B, Essers MAG, and King KY. (2021) Yin and yang: the dual effects of interferons on hematopoiesis. Exp. Hematol. 96:1-12. PMID: 33571568.

Han H, Yan H, King KY. (2021) Broad-Spectrum Antibiotics Deplete Bone Marrow Regulatory T Cells. Cells. 10(2):277. PMID: 33573218.

Florez M, Matatall KA, Jeong Y, Ortinau L, Shafer P, Lynch A, Jaksik R, Kimmel M, Park D, and King KY. (2020) IFNg mediates hematopoietic stem cell activation and niche relocalization through BST2.  Cell Reports. 33(12):108530. PMID: 33357430.

Morales-Mantilla, DE, Huang X, Erice P, Porter P, Zhang Y, Figueroa M, Chandra M, King KY, Kheradmand F, and Rodriguez A. Cigarette smoke exposure in mice using a whole-body inhalation system. (2020) JoVE. doi: 10.3791/61793. PMID: 33165327.

Chen J, Matatall KA, Feng X, Hormaechea-Agulla D, Maharjan M, Young N, and King KY. Dnmt3a-null hematopoietic progenitor stem cells expand after busulfan
treatment. Exp. Hematol. (2020) PMID: 32961298.

Hormaechea-Agulla D, Le DT, King KY. Common Sources of Inflammation and Their Impact on Hematopoietic Stem Cell Biology. Curr Stem Cell Rep. (2020) Aug 17:1-12. doi: 10.1007/s40778-020-00177-z. PMID: 32837857; PMCID: PMC7429415.

Roland D, Van Driest SL, Heerman WJ, King KY, Maitre NL, Fritz SA, and Barkin S. (2020) Navigating success for early stage investigators—practical words of advice. Pediatr Res. https://doi.org/10.1038/s41390-020-0949-8.

King KY, Huang Y, Nakada D, and Goodell MA. (2020) Environmental influences on clonal hematopoiesis. Exp Hematol. 83:66-73. PMID: 318935324.

Zeng H, He H, Guo L, Li J, Lee M, Han W, Guzman AG, Zang S, Zhou Y, Zhang X, Goodell MA, King KY, Sun D, Huang Y. (2019) Antibiotic treatment ameliorates Ten-eleven translocation 2 (TET2) loss-of-function associated hematological malignancies. Cancer Lett. 467:1-8. PMID: 31563562

Niles D, Boguniewicz J, Shakeel O, Margolin J, Chelius D, Gupta M, Paul D, King KY, McNeil JC. (2019) Candida tropicalis thyroiditis presenting with thyroid storm in a pediatric patient with acute lymphocytic leukemia. Ped Infect Dis J. 38(10):1051-3. PMID: 31365478

Kennedy EA, King KY, and Baldridge MT. (2018) Mouse microbiota models: comparing germ-free mice and antibiotics treatment as tools for modifying gut bacteria. Front Physiol. 9:1534. PMID: 30429801

Yan H, Baldridge MT, King KY. (2018) Hematopoiesis and the Bacterial Microbiome. Blood; 132(6):559-564. PMID: 29853538

Morales-Mantilla DE, King KY. (2018) The Role of Interferon-Gamma in Hematopoietic Stem Cell Development, Homeostasis, and Disease. Current Stem Cell Reports; 4(3): 264-271. PMID: 30148048

Matatall KA, Kadmon CS, King KY. (2018) Detecting Hematopoietic Stem Cell Proliferation Using BrdU Incorporation. Methods in Molecular Biology; 1686:91-103. PMID: 29030815

Kadmon CS, Landers CT, Li HS, Watowich SS, Rodriguez A, King KY. (2017) MicroRNA-22 controls interferon alpha production and erythroid maturation in response to infectious stress in mice. Experimental Hematology; 56:7-15. PMID: 28911907

Josefsdottir KS, Baldridge MT, Kadmon CS, and King KY. (2017) Antibiotics impair murine hematopoiesis by depleting intestinal microbiota. Blood. 129(6):729-739. PMID: 7879260

Matatall KA, Jeong M, Chen S, Sun D, Chen F, Mo Q, Kimmel M, and King KY. (2016) Chronic infection depletes hematopoietic stem cells through stress-induced terminal differentiation. Cell Reports. 17, 2584-95. PMID: 27926863

King KY, Matatall KA, Shen C, Goodell MA, Swierczek SI, and Prchal JT. (2015) Comparative Long-term Effects of Interferon Alpha and Hydroxyurea on Human Hematopoietic Progenitor Cells. Experimental Hematology. PMID: 26072330

Matatall, KA, Shen CC, Challen GA, King KY. (2014) Type II interferon promotes differentiation of myeloid-biased hematopoietic stem cells. Stem Cells. PMID: 25078851

King KY, Lew JD, Lin JS, Ma X, Graviss EA, and Goodell MA. (2011) A deletion polymorphism upstream of human IRGM1 is associated with tuberculosis disease susceptibility. PLoS One. 6(1):e16317. PMID: 21283700

King KY, Goodell MA. (2011) Inflammatory modulation of HSCs: viewing the HSC as a foundation to the immune response. Nature Rev Immunol. 11(10):685-92. PMID: 21904387

King KY*, Baldridge MT*, Weksberg DC, Chambers SM, Lukov GL, Wu S, Boles NC, Jung SY, Qin J, Liu D, Songyang Z, Eissa NT, Taylor GA, and Goodell MA. (2011) Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood. 118(6):1525-33. PMID: 21633090

Baldridge MT*, King KY*, Boles NC, Weksberg DC, and Goodell MA. (2010) Quiescent hematopoietic stem cells are activated by IFNg in response to chronic infection. Nature. 465:793-7. PMID: 20535209