Weather Update

BCM Family Medicine on Kirby is without electrical power. Patients with appointments on Tuesday at this location will be moved to Baylor Medicine on the McNair Campus:  7200 Cambridge St, 7th floor, Suite 7B. Patients will be contacted. For questions, call 713-798-7700.

Kevin Phillips Lab



* Denotes author of correspondence.

Amato AA, Rajagopalan S, Lin JZ, Carvalho BM, Figueira ACM, Lu J, Ayers SD, Mottin M, Silveira RL, Souza PCT, Mourão RHV, Saad MJA, Togashi M, Simeoni LA, Abdalla DSP, Skaf MS, Polikparpov I, Lima MCA, Galdino SL, Brennan RG, Baxter JD, Pitta IR, Webb P, Phillips KJ*, Neves FAR*. GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain. J Biol Chem. 2012 Aug 10;287(33):28169-79.

Biter AB, de la Peña AH, Thapar R, Lin JZ, Phillips KJ*. DSF guided refolding as a novel method of protein production. Sci Rep. 2016 Jan 19;6:18906.

Bittker JA, Phillips KJ, Liu DR. Recent advances in the in vitro evolution of nucleic acids. Curr Opin Chem Biol. 2002 Jun;6(3):367-74.

Deng T, Lyon CJ, Minze LJ, Lin J, Zou J, Liu JZ, Ren Y, Zhen L, Hamilton D, Reardon PR, Sherman V, Wang HY, Phillips KJ, Webb P, Wong ST, Wang RF, Hsueh WA. Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab. 2013 Mar 5;17(3):411–22.

Estébanez-Perpiñá E, Arnold LA, Jouravel N, Togashi M, Blethrow J, Mar E, Nguyen P, Phillips KJ, Baxter JD, Webb P, Guy RK, Fletterick RJ. Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Mol Endocrinol. 2007 Dec;21(12):2919-28.

Filgueira CS, Nicolov E, Hood RL, Ballerini A, Garcia-Huidobro J, Lin JZ, Fraga D, Webb P, Sabek OM, Gaber AO, Phillips KJ, Grattoni A. Sustained zero-order delivery of GC-1 from a nanochannel membrane device alleviates metabolic syndrome. Int J Obes (Lond). 2016 Nov;40(11):1776-83.

Horton LB, Shanker S, Mikulski R, Brown NG, Phillips KJ, Lykissa E, Venkataram Prasad BV, Palzkill T. Mutagenesis of zinc ligand residue Cys221 reveals plasticity in the IMP-1 metallo-β-lactamase active site. Antimicrob Agents Chemother. 2012 Nov;56(11):5667-77.

Lawrence MS, Phillips KJ, Liu DR. Supercharging proteins can impart unusual resilience. J Am Chem Soc. 2007 Aug 22;129(33):10110-2. This work was featured as a Research Highlight in Nature 448, 973 (2007) and as a News and Views article in Nature 449, 555 (2007).

Liberato MV, Nascimento AS, Ayers SD, Lin JZ, Cvoro A, Silveira RL, Martínez L, Souza PCT, Saidemberg D, Deng T, Amato AA, Togashi M, Hsueh WA, Phillips K, Palma MS, Neves FAR, Skaf MS, Webb P, Polikarpov I. Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists. PLoS ONE 2012;7(5):e36297.

Lin JZ, Martagón AJ, Cimini SL, Gonzalez DD, Tinkey DW, Biter A, Baxter JD, Webb P, Gustafsson JÅ, Hartig SM, Phillips KJ*. Pharmacological activation of thyroid hormone receptors elicits a functional conversion of white to brown fat. Cell Rep. 2015 Nov 24;13(8):1528-37.

Lin JZ, Martagón AJ, Hsueh WA, Baxter JD, Gustafsson JÅ, Webb P, Phillips KJ*. Thyroid hormone receptor agonists reduce serum cholesterol independent of the LDL receptor. Endocrinology. 2012 Dec;153(12):6136-44. This work was featured as a Research Highlight in Nature Reviews Endocrinology 2012;9(1):3 and as a Recommended Article by the Faculty of 1000, Nov 8, 2012.

Lou X, Toresson G, Benod C, Suh JH, Phillips KJ, Webb P, Gustafsson JA. Structure of the retinoid X receptor α-liver X receptor β (RXRα-LXRβ) heterodimer on DNA. Nat Struct Mol Biol. 2014 Mar;21(3):277–81.

Martagón AJ, Lin JZ, Cimini SL, Webb P, Phillips KJ*. The amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob/ob mice. PLoS One. 2015 Apr 7;10(4):e0122987.

Martínez L, Nascimento AS, Nunes FM, Phillips K, Aparicio R, Dias SMG, Figueira ACM, Lin JH, Nguyen P, Apriletti JW, Neves FAR, Baxter JD, Webb P, Skaf MS, Polikarpov I. Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20717-22.

Phillips K*, de la Peña AH. The combined use of the Thermofluor assay and ThermoQ analytical software for the determination of protein stability and buffer optimization as an aid in protein crystallization. Curr Protoc Mol Biol. 2011 Apr;Chapter 10:Unit10.28.

Phillips KJ, Rosenbaum DM, Liu DR. Binding and stability determinants of the PPARgamma nuclear receptor-coactivator interface as revealed by shotgun alanine scanning and in vivo selection. J Am Chem Soc. 2006 Aug 30;128(34):11298-306.

Rajagopalan S, Teter SJ, Zwart PH, Brennan RG, Phillips KJ*, Kiley PJ*. Studies of IscR reveal a unique mechanism for metal-dependent regulation of DNA binding specificity. Nat Struct Mol Biol. 2013 Jun;20(6):740–7.

Riu A, Grimaldi M, le Maire A, Bey G, Phillips K, Boulahtouf A, Perdu E, Zalko D, Bourguet W, Balaguer P. Peroxisome proliferator-activated receptor γ is a target for halogenated analogs of bisphenol A. Environ Health Perspect. 2011 Sep;119(9):1227-32.

Webb P, Phillips KJ, Baxter JD. Mechanisms of thyroid hormone action. In: Jameson JL, DeGroot LJ, eds. Endocrinology: adult and pediatric, 6th ed. Philadelphia, PA; London: Saunders; 2010.