Weather Update

BCM Family Medicine on Kirby is without electrical power. Patients with appointments on Tuesday at this location will be moved to Baylor Medicine on the McNair Campus:  7200 Cambridge St, 7th floor, Suite 7B. Patients will be contacted. For questions, call 713-798-7700.

Shaji Chacko Lab

Shaji Chacko Lab Publications


Chacko SK, Sunehag AL, Sharma S, Sauer PJ, Haymond MW: Measurement of gluconeogenesis using glucose fragments and mass spectrometry after ingestion of deuterium oxide. J Appl Physiol 2008;104:944-951.

Chacko SK, Sunehag AL: Gluconeogenesis continues in premature infants receiving total parenteral nutrition. Arch Dis Child Fetal Neonatal Ed 2010;95:F413-418.

Chacko SK, Ordonez J, Sauer PJJ, Sunehag AL: Gluconeogenesis is not regulated by either glucose or insulin in extremly low birth weight infants receiving total parenteral nutrition. Journal of pediatrics 2011, 158(6):891-6.

Mohammad MA, Sunehag AL, Chacko SK, Pontius AS, Maningat PD, Haymond MW: Mechanisms to conserve glucose in lactating women during a 42-h fast. Am J Physiol Endocrinol Metab 2009;297:E879-888.

Hertel PM, Chacko SK, Pal S, Sunehag AL, Haymond MW: Subcutaneous infusion and capillary "finger stick" sampling of stable isotope tracer in metabolic studies. Pediatr Res 2006;60:597-601.

Chacko SK, Haymond MW, Sun Y, Marini JC, Sauer PJ, Ma X, Sunehag AL: Effect of ghrelin on glucose regulation in mice. Am J Physiol Endocrinol Metab 2012;302(9):E1055-62.

Riedijk MA, Stoll B, Chacko S, Schierbeek H, Sunehag AL, van Goudoever JB, Burrin DG: Methionine transmethylation and transsulfuration in the piglet gastrointestinal tract. Proc Natl Acad Sci U S A 2007;104:3408-3413.

Verbruggen S, Sy J, Gordon WE, Hsu JW, Wu M, Chacko SK, Zurakowski D, Burrin DG, Castillo L: Ontogeny of methionine utilization and splanchnic uptake in critically ill children. Am J Physiol Endocrinol Metab 2009.

Bauchart-Thevret C, Stoll B, Chacko S, Burrin DG: Sulfur amino acid deficiency upregulates intestinal methionine cycle activity and suppresses epithelial growth in neonatal pigs. Am J Physiol Endocrinol Metab 2009;296:E1239-1250.

Benight NM, Stoll B, Chacko S, da Silva VR, Marini JC, Gregory JF 3rd, Stabler SP, Burrin DG. B-Vitamin deficiency is protective against DSS-induced colitis in mice. Am J Physiol Gastointest Liver Physiol. 2011;301(2):G249-59.

Verbruggen SC, de Betue CT, Schierbeek H, Chacko S, van Adrichem LN, Verhoeven J, van Goudoever JB, Joosten KF. Reducing glucose infusion safely prevents hyperglycemia in post-surgical children. Clin Nutr. 2011; 30(6):786-92.

de Betue CT, Verbruggen SC, Schierbeek H, Chacko SK, Bogers AJ, van Goudoever JB, Joosten KF. Does a reduced glucose intake prevent hyperglycemia in children early after cardiac surgey? A randomized controlled crossover study. Crit Care. 2012; 16(5):R176.

Diaz-Sotomayor M, Quezada-Calvillo R, Avery SE, Chacko SK, Yan LK, LinAH, Ao ZH, Hamaker BR, Nichols BL: Maltase-glucoamylase modulates gluconeogenesis and sucrase-isomaltase dominates starch digestion glucogenesis. J Pediatr Gastroenterol Nutr. 2013;57(6):704-12.

Vlaardingerbroek H, Ng K, Stoll B, Benight N, Chacko S, Kluijtmans LA, Kulik W, Squires EJ, Olutoye O, Schady D, Finegold ML, van Goudoever JB, Burrin DG: New Generation lipid emulsions prevent PNALD in chronic parenterally-fed preterm pigs. J Lipid Res. 2014 Mar; 55(3):466-77.

Chung S, Hsia D, Chacko SK, Rodrguez LM, Haymond MW: Increased gluconeogenesis in youth with newly diagnosed type 2 Diabetes. Diabetologia. 2015 Mar; 58(3):596-603.

Ng K, Stoll B, Chacko S, Saenz de Pipaon M, Laurisden C, Gray M, Squires EJ, Marini J, Zamora IJ, Olutoye OO, Burrin DG: Vitamin E in New-Generation Lipid Emulsions protects against PNALD in parenteral nutrition-fed preterm pigs. JPEN J Parenteral Enteral Nutrition. 2015.

Chung ST, Chacko SK, Sunehag AL, Haymond MW. Measurements of Gluconeogenesis and Glycogenolysis: A Methodological Review. Diabetes. 2015 Dec; 64(12):3996-4010.

Hsu JW, Thame MM, Gibson R, Baker TM, Tang GJ, Chacko SK, Jackson AA, Jahoor F. Unlike pregnant adult women, pregnant adolescent girls cannot maintain glycine flux during late pregnancy because of decreased synthesis from serine. Br J Nutr. 2016 Mar 14; 115(5):759-63.

Nichols BL, Diaz-Sotomayor M, Avery SE, Chacko SK, Hadsell DL, Baker SS, Hamaker BR, Yan LK, Lin HM, Quezada-Calvillo R. Milk glucosidase activity enables suckled pup starch digestion. Mol Cell Pediatr. 2016 Dec; 3(1):4.

Blesson CS, Schutt AK, Balakrishnan MP, Pautler RG, Pedersen SE, Sarkar P, Gonzales D, Zhu G, Marini JC, Chacko SK, Yallampalli U, Yallampalli C. Novel lean type 2 diabetic rat model using gestational low-protein programming. Am J Obstet Gynecol. 2016 Apr; 214(4):540.e1-7.

Webster CC, Noakes TD, Chacko SK, Swart J, Kohn TA, Smith JA. Gluconeogenesis during endurance exercise in cyclists habituated to a long-term low carbohydrate high fat diet. J Physiol. 2016 Aug 1;594(15):4389-405.

Nichols BL, Avery SE, Quezada-Calvillo R, Kilani SB, Lin AH, Burrin DG, Hodges BE, Chacko SK, Opekun AR, Hindawy ME, Hamaker BR, Oda SI. Improved Starch Digestion of Sucrase Deficient Shrews Treated with Oral Glucoamylase Enzyme Supplements. J Pediatr Gastroenterol Nutr. 2017 Mar 6. PMID: 28267073.

Axelsson AS, Tubbs E, Mecham B, Chacko S, Nenonen HA, Tang Y, Fahey JW, Derry JMJ, Wollheim CB, Wierup N, Haymond MW, Friend SH, Mulder H, Rosengren AH. Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 Diabetes. Sci Transl Med. 2017 Jun 14;9(394).

Shi X, Chacko S, Li F, Li D, Burrin D, Chan L, Guan X. Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity. Mol Metab. 2017 Nov;6(11):1350-1359. PMID: 29107283. PMCID: PMC5681239.

Tan HC, Yew TW, Chacko S, Tai ES, Kovalik JP, Ching J, Myo Thant S, Khoo CM. Comprehensive assessment of insulin resistance in non-obese Asian Indian and Chinese men. J Diabetes Investig. 2018 Mar 27. Doi: 10.1111/jdi.12844 PMID: 29582571.

Chung ST, Courville AB, Onuzuruike AU, Galvan-De La Cruz M, Mabundo LS, DuBose CW, Kasturi K, Cai H, Gharib AM, Walter PJ, Garraffo HM, Chacko S, Haymond MW, Sumner AE. Gluconeogenesis and risk for fasting hyperglycemia in Black and White women. JCI Insight. 2018 Sep 20:3(18). PMID:30232289.

Tan HC, Hsu JW, Khoo CM, Tai ES, Yu S, Chacko S, Lai OF, Jahoor F. Alterations in branched-chain amino acid kinetics in nonobese but insulin-resistant Asian men. Am J Clin Nutr. 2018 Dec 1;108(6):1220-1228. PMID:30358799.

Cade WT, Bohnert KL, Peterson LR, Patterson BW, Bittel AJ, Okunade AL, de Las Fuentes L, Steger-May K, Bashir A, Schweitzer GG, Chacko SK, Wanders RJ, Pacak CA, Byrne BJ, Reeds DN. Blunted fat oxidation upon submaximal exercise is partially compensated by enhanced glucose metabolism in children, adolescents and yound adults with barth syndrome. J Inherit Metab Dis. 2019 Mar 29. Doi:10.1002/jimd.12094. PMID:30924938.

Blesson CS, Schutt A, Chacko S, Marini JC, Mathew PR, Tanchico D, Balakrishnan M, Yallampalli C. Sex dependent regulation of hepatic glucose production in lean type 2diabetic rats. Front Endocrinol (Lausanne). 2019;10:538. doi: 10.3389/fendo.2019.00538. 2019. PMID: 31447783; PMCID: PMC6691354.

Guthrie G, Stoll B, Chacko S, Lauridsen C, Plat J, Burrin D. Rifampicin, not vitamin E, suppresses parenteral nutrition-associated liver disease development through the pregnane X receptor pathway in piglets. Am J Physiol Gastrointest Liver Physiol. 2020 1;318(1):G41-G52.doi:10.1152/ajpgi.00193.2019.PMID:31604032; PMCID: PMC6985848.

Sekizkardes H, Chung ST, Chacko S, Haymond M, Startzell M, Walter M, Walter PJ, Lightbourne M, Brown RJ. Free fatty acid processing diverges in human pathologic insulin resistance conditions. J Clin Invest. 2020 Mar 19. doi: 10.1172/JCI135431. PMID: 32191645.

Call L, Molina T, Stoll B, Guthrie G, Chacko S, Plat J, Robinson J, Lin S, Vonderohe C, Mohammad M, Kunichoff D, Cruz S, Lau P, Premkumar M, Nielsen J, Fang Z, Olutoye O, Thymann T, Britton R, Sangild P, Burrin D. Parenteral lipids shape gut bile acid pools and microbiota profiles in the prevention of cholestasis in preterm pigs. J Lipid Res. 2020;61(7):1038-1051. doi: 10.1194/jlr.RA120000652. Epub 2020 Apr 29. PMID: 32350078.

Baykal AP, Parks EJ, Shamburek R, Syed-Abdul MM, Chacko S, Cochran E, Startzell M, Gharib AM, Ouwerkerk R, Abd-Elmoniem KZ, Walter PJ, Walter M, Muniyappa R, Chung ST, Brown RJ. Leptin decreases de novo lipogenesis in patients with lipodystrophy. JCI Insight. 2020 Jul 23;5(14):e137180. doi: 10.1172/jci.insight.137180. PMID: 32573497.

Hasek LY, Avery SE, Chacko SK, Fraley JK, Vohra FA, Quezada-Calvillo R, Nichols BL, Hamaker BR. Conditioning with slowly digestible starch diets in mice reduces jejunal α-glucosidase activity and glucogenesis from a digestible starch feeding. Nutrition. 2020 Oct;78:110857. doi: 10.1016/j.nut.2020.110857. Epub 2020 May 15. PMID: 32599415.

Cravalho CKL, Meyers AG, Mabundo LS, Courville A, Yang S, Cai H, Dai Y, Walter M, Walter PJ, Sharma S, Chacko S, Cogen F, Magge SN, Haymond MW, Chung ST. Metformin improves blood glucose by increasing incretins independent of changes in gluconeogenesis in youth with type 2 diabetes. Diabetologia. 2020 Oct;63(10):2194-2204. doi: 10.1007/s00125-020-05236-y. Epub 2020 Jul 29. PMID: 32728891.

Kumar P, Liu C, Suliburk JW, Minard CG, Muthupillai R, Chacko S, Hsu JW, Jahoor F, Sekhar RV. Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clinical Trial. Biomedicines. 2020 Sep 30;8(10):390. doi: 10.3390/biomedicines8100390. PMID: 33007928.

Tan HC, Hsu JW, Kovalik JP, Eng A, Chan WH, Khoo CM, Tai ES, Chacko S, Jahoor F. Branched-Chain Amino Acid Oxidation Is Elevated in Adults with Morbid Obesity and Decreases Significantly after Sleeve Gastrectomy. J Nutr. 2020 Dec 10;150(12):3180-3189. doi: 10.1093/jn/nxaa298. PMID: 33097955.

Cade WT, Bohnert KL, Bittel AJ, Chacko SJ, Patterson BW, Pacak CA, Byrne BJ, Vernon HJ, Reeds DN. Arginine kinetics are altered in a pilot sample of adolescents and young adults with Barth syndrome. Mol Genet Metab Rep. 2020 Nov 4;25:100675. doi: 10.1016/j.ymgmr.2020.100675. eCollection 2020 Dec. PMID: 33204638.

Guthrie G, Stoll B, Chacko S, Mohammad M, Style C, Verla M, Olutoye O, Schady D, Lauridsen C, Tataryn N, Burrin D. Depletion and enrichment of phytosterols in soybean oil lipid emulsions directly associate with serum markers of cholestasis in preterm parenteral nutrition-fed pigs. JPEN JPEN J Parenter Enteral Nutr. 2022; 46(1):160-171. PMID: 33581699.

Kumar P, Liu C, Hsu JW, Chacko S, Minard C, Jahoor F, Sekhar RV. Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial. Clin Transl Med. 2021 Mar;11(3):e372.

Vonderohe C, Guthrie G, Stoll B, Chacko S, Dawson H, Burrin D. Tissue-specific mechanisms of bile acid homeostasis and activation of FXR-FGF19 Signaling in preterm and term neonatal pigs. Am J Physiol Gastrointest Liver Physiol. 2022;322(1):G117-G133, PMID: 34851728.

Quaye E, Chacko S, Chung S, Brychta R, Chen K, Brown R. Energy expenditure due to gluconeogenesis in pathologic conditions of insulin resistance. Am J Physiol Endocrinol Metab 321: E795–E801, 2021.

Gannon AL, Chacko SK, Didelija IC, Marini JC, Blesson CS. Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model. J Vis Exp. 2022 5;(181). PMID: 35312673.

Tan HC, Hsu JW, Tai ES, Chacko S, Wu V, Lee CF, Kovalik JP, Jahoor F. De Novo Glycine Synthesis Is Reduced in Adults With Morbid Obesity and Increases Following Bariatric Surgery. Front Endocrinol (Lausanne). 2022;13:900343. PMID: 35757406.

Complete List of Published Work in MyBibliography.