Positions
- Professor
-
Verna and Marrs McLean Department of Biochemistry and Molecular Biology
Baylor College of Medicine
Houston, Texas United States
Primary Appointment
- Alvin Romansky Chair in Biochemistry
-
Verna and Marrs McLean Department of Biochemistry and Molecular Biology
Baylor College of Medicine
Houston, Texas United States
- Director
-
Graduate Program in Chemical, Physical & Structural Biology
Baylor College of Medicine
- Professor
-
Molecular Virology and Microbiology
Baylor College of Medicine
Houston, Texas United States
Secondary Appointment
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- BCM-Alkek Graduate School (Office)
-
Room: BCMN-N410
Houston, TX 77030
United States
Education
- Postdoctoral Fellowship at University of Arizona
- 01/1988 - Tucson, Arizona United States
- Postdoctoral Training at Indian Institute of Science
- 01/1984 - Bangalore, Karnataka India
- PhD from Indian Institute of Science
- 01/1981 - Bangalore, Karnataka India
- MSc from Indian Institute of Technology
- 01/1974 - Bombay, Maharashtra India
- BSc from Bangalore University
- 01/1972 - Bangalore, Karnataka India
Honors & Awards
- Fellow of the American Academy of Microbiology
- Fellow of the American Academy of Microbiology
- American Academy of Microbiology (08/2015)
- Ruth McLean Bowman Bowers Excellence in Research Award
- Baylor College of Medicine (01/2013)
- Ruth McLean Bowman Bowers Excellence in Research Award
- Baylor College of Medicine (01/2010)
- Alvin Romansky Professor and Chair of Biochemistry
- Baylor College of Medicine (07/2008)
- Indo-US Professorship for the American Society of Microbiology
- American Society of Microbiology (01/2004 - 12/2005)
- NIH MERIT award
- NIH MERIT award (01/2003)
- Indian National Science Academy Medal for Young Scientists
- Indian National Science Academy Medal for Young Scientists (01/1983)
- NIAID MERIT Award
- The MERIT award is given to investigators who have demonstrated superior competence and outstanding productivity in their research
- National Institute of Allergy and Infectious Diseases (09/2013)
Professional Interests
- Protein Structure-Function and Protein Folding
- Virology, biochemistry, immunology and cell biology of viral and microbial pathogen
- Glycobiology of pathogen-host interactions
- Host-pathogen coevolution
- Cellular Antiviral Responses
- Antiviral Drug Discovery/Design, and Vaccine Strategies
- Quantitative and Computational Biosciences
- Viral Pathogens
Professional Statement
Main focus of our research program, largely funded by NIH and Welch foundation, is to understand structure-function relationships in medically important viruses with a clear emphasis on using this knowledge to develop/design effective antiviral drugs. Our structure-function studies are mainly focused on three human pathogens: Rotaviruses, which are major pathogens of infantile gastroenteritis; Noroviruses in Caliciviridae (NIAD priority B biodefense pathogen), which cause epidemic diarrhea in humans; and influenza viruses (NIAD priority C biodefense pathogen), which cause seasonal and pandemic flu.Our approach is to use a variety of structural techniques including cryo-electron microscopy and X-ray crystallography along with various biochemical and cell biology techniques to elucidate structure-function relationships in these human pathogens. In addition to understanding the structural basis for the capsid-related activities such as how viruses gain entry into host cells, how they interact with receptors, how they evade immune surveillance, and how they disassemble, we also focus on understanding the molecular processes by which these viruses successfully replicate once inside the host cells. The latter processes, which include genome transcription, viral protein synthesis, genome replication and encapsidation, and finally assembly of the new virions, are controlled by exquisite interplay between virus-encoded non-structural proteins some of which have fascinating enzymatic activities. Although these processes vary from one virus to another they are conserved between various strains in each virus family, thus making them suitable targets for designing and developing effective antiviral strategies.
One of the fascinating aspects of virus replication is how these viruses counteract antiviral response mounted by the host cells, for example, interferon response. Each virus appears to specially designate a viral protein to antagonize the host immune response. In rotavirus it is the non-structural protein NSP1 and in influenza virus it is NS1. During this process, these viral proteins target critical cellular pathways by interacting with various cellular proteins. Thus our research on understanding the molecular basis of such a process provides an excellent opportunity to interface with cell biology.
Websites
Selected Publications
- Lawton JA, Estes MK, Prasad BV "Three-dimensional visualization of mRNA release from actively transcribing rotavirus particles.." Nat. Struct. Biol.. 1997 Feb;4(2):118-21. Pubmed PMID: 9033591
- Prasad BV, Rothnagel R, Zeng CQ, Jakana J, Lawton JA, Chiu W, Estes MK "Visualization of ordered genomic RNA and localization of transcriptional complexes in rotavirus.." Nature. 1996 Aug 1;382(6590):471-3. Pubmed PMID: 8684490
- Prasad BV, Hardy ME, Dokland T, Bella J, Rossmann MG, Estes MK "X-ray crystallographic structure of the Norwalk virus capsid.." Science. 1999 Oct 8;286(5438):287-90. Pubmed PMID: 10514371
- Bornholdt ZA, Prasad BV "X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus.." Nature. 2008 Dec 18;456(7224):985-8. Pubmed PMID: 18987632
- Shanker S, Choi JM, Sankaran B, Atmar RL, Estes MK, Prasad BV "Structural Analysis of Histo-Blood Group Antigen Binding Specificity in a Norovirus GII.4 Epidemic Variant: Implications for Epochal Evolution.." J. Virol.. 2011 Sep;85(17):8635-45. Pubmed PMID: 21715503
- Shaw AL, Rothnagel R, Chen D, Ramig RF, Chiu W, Prasad BV "Three-dimensional visualization of the rotavirus hemagglutinin structure.." Cell. 1993 Aug 27;74(4):693-701. Pubmed PMID: 8395350
- Chen R, Neill JD, Estes MK, Prasad BV "X-ray structure of a native calicivirus: structural insights into antigenic diversity and host specificity.." Proc. Natl. Acad. Sci. U.S.A.. 2006 May 23;103(21):8048-53. Pubmed PMID: 16702551
- Citovsky V, Wong ML, Shaw AL, Prasad BV, Zambryski P "Visualization and characterization of tobacco mosaic virus movement protein binding to single-stranded nucleic acids.." Plant Cell. 1992 Apr;4(4):397-411. Pubmed PMID: 1379865
- Prasad BV, Prevelige PE "Viral genome organization.." Adv. Protein Chem.. 2003;64:219-58. Pubmed PMID: 13677049
- Crawford SE, Mukherjee SK, Estes MK, Lawton JA, Shaw AL, Ramig RF, Prasad BV "Trypsin cleavage stabilizes the rotavirus VP4 spike.." J. Virol.. 2001 Jul;75(13):6052-61. Pubmed PMID: 11390607
- Criglar JM1, Hu L, Crawford SE, Hyser JM, Broughman JR, Prasad BV, Estes MK. "A novel form of rotavirus NSP2 and phosphorylation-dependent NSP2-NSP5 interactions are associated with viroplasm assembly." J Virol. 2014 Jan;88(2):786-98. Pubmed PMID: 24198401
- Grimes JM, Jakana J, Ghosh M, Basak AK, Roy P, Chiu W, Stuart DI, Prasad BV "An atomic model of the outer layer of the bluetongue virus core derived from X-ray crystallography and electron cryomicroscopy.." Structure. 1997 Jul 15;5(7):885-93. Pubmed PMID: 9261080
- Brown NG, Chow DC, Sankaran B, Zwart P, Prasad BV, Palzkill T "Analysis of the Binding Forces Driving the Tight Interactions between {beta}-Lactamase Inhibitory Protein-II (BLIP-II) and Class A {beta}-Lactamases.." J. Biol. Chem.. 2011 Sep 16;286(37):32723-35. Pubmed PMID: 21775426
- Ajami NJ, Barry MA, Carrillo B, Muhaxhiri Z, Neill FH, Prasad BV, Opekun AR, Gilger MA, Graham DY, Atmar RL, Estes MK "Antibody Responses to Norovirus Genogroup GI.1 and GII.4 Proteases in Volunteers Administered Norwalk Virus.." Clin. Vaccine Immunol.. 2012 Dec;19(12):1980-3. Pubmed PMID: 23035177
- Chung SH, Frese KK, Weiss RS, Prasad BV, Javier RT "A new crucial protein interaction element that targets the adenovirus E4-ORF1 oncoprotein to membrane vesicles.." J. Virol.. 2007 May;81(9):4787-97. Pubmed PMID: 17314165
- Choi JM, Hutson AM, Estes MK, Prasad BV "Atomic resolution structural characterization of recognition of histo-blood group antigens by Norwalk virus.." Proc. Natl. Acad. Sci. U.S.A.. 2008 Jul 8;105(27):9175-80. Pubmed PMID: 18599458
- Mathieu M, Petitpas I, Navaza J, Lepault J, Kohli E, Pothier P, Prasad BV, Cohen J, Rey FA "Atomic structure of the major capsid protein of rotavirus: implications for the architecture of the virion.." EMBO J.. 2001 Apr 2;20(7):1485-97. Pubmed PMID: 11285213
- Zeng CQ, Labbé M, Cohen J, Prasad BV, Chen D, Ramig RF, Estes MK "Characterization of rotavirus VP2 particles.." Virology. 1994 May 15;201(1):55-65. Pubmed PMID: 8178489
- Lawton JA, Estes MK, Prasad BV "Comparative structural analysis of transcriptionally competent and incompetent rotavirus-antibody complexes.." Proc. Natl. Acad. Sci. U.S.A.. 1999 May 11;96(10):5428-33. Pubmed PMID: 10318900
- Prasad BV, Chandrasekaran R "Conformation of polypeptide chains containing both L- and D-residues. II. Double-helical structures of poly-LD-peptides.." Int. J. Pept. Protein Res.. 1977;10(2):129-38. Pubmed PMID: 892986
- Ossiboff RJ, Zhou Y, Lightfoot PJ, Prasad BV, Parker JS "Conformational changes in the capsid of a calicivirus upon interaction with its functional receptor.." J. Virol.. 2010 Jun;84(11):5550-64. Pubmed PMID: 20357100
- Jiang X, Jayaram H, Kumar M, Ludtke SJ, Estes MK, Prasad BV "Cryoelectron microscopy structures of rotavirus NSP2-NSP5 and NSP2-RNA complexes: implications for genome replication.." J. Virol.. 2006 Nov;80(21):10829-35. Pubmed PMID: 16928740
- Chen R, Neill JD, Prasad BV "Crystallization and preliminary crystallographic analysis of San Miguel sea lion virus: an animal calicivirus.." J. Struct. Biol.. 2003 Feb;141(2):143-8. Pubmed PMID: 12615540
- Hu L, Chow DC, Patton JT, Palzkill T, Estes MK, Prasad BV "Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5' GG Sequence for RTPase Activity.." J. Virol.. 2012 Oct;86(19):10547-57. Pubmed PMID: 22811529
- Kumar M, Jayaram H, Vasquez-Del Carpio R, Jiang X, Taraporewala ZF, Jacobson RH, Patton JT, Prasad BV "Crystallographic and biochemical analysis of rotavirus NSP2 with nucleotides reveals a nucleoside diphosphate kinase-like activity.." J. Virol.. 2007 Nov;81(22):12272-84. Pubmed PMID: 17804496
- Zheng B1, Yao Y, Liu Z, Deng L, Anglin JL, Jiang H, Prasad BV, Song Y. "Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase." ACS Med Chem Lett.. 2013 Jun 13;4(6):542-546. Pubmed PMID: 23795241
- Talmon Y, Prasad BV, Clerx JP, Wang GJ, Chiu W, Hewlett MJ "Electron microscopy of vitrified-hydrated La Crosse virus.." J. Virol.. 1987 Jul;61(7):2319-21. Pubmed PMID: 3586135
- Jayaram H, Estes MK, Prasad BV "Emerging themes in rotavirus cell entry, genome organization, transcription and replication.." Virus Res.. 2004 Apr;101(1):67-81. Pubmed PMID: 15010218
- Prasad BV, Degn LL, Jeng TW, Chiu W "Estimation of allowable errors for tilt parameter determination in protein electron crystallography.." Ultramicroscopy. 1990 Oct;33(4):281-5. Pubmed PMID: 2260229
- Chakravarty S, Hutson AM, Estes MK, Prasad BV "Evolutionary trace residues in noroviruses: importance in receptor binding, antigenicity, virion assembly, and strain diversity.." J. Virol.. 2005 Jan;79(1):554-68. Pubmed PMID: 15596848
- Singh S, Rothnagel R, Prasad BV, Buckley B "Expression of tobacco ringspot virus capsid protein and satellite RNA in insect cells and three-dimensional structure of tobacco ringspot virus-like particles.." Virology. 1995 Nov 10;213(2):472-81. Pubmed PMID: 7491772
- Kallewaard NL, McKinney BA, Gu Y, Chen A, Prasad BV, Crowe JE "Functional maturation of the human antibody response to rotavirus.." J. Immunol.. 2008 Mar 15;180(6):3980-9. Pubmed PMID: 18322207
- Chung SH, Weiss RS, Frese KK, Prasad BV, Javier RT "Functionally distinct monomers and trimers produced by a viral oncoprotein.." Oncogene. 2008 Feb 28;27(10):1412-20. Pubmed PMID: 17828302
- Monnier N, Higo-Moriguchi K, Sun ZY, Prasad BV, Taniguchi K, Dormitzer PR "High-resolution molecular and antigen structure of the VP8* core of a sialic acid-independent human rotavirus strain.." J. Virol.. 2006 Feb;80(3):1513-23. Pubmed PMID: 16415027
- Weiss RS, Lee SS, Prasad BV, Javier RT "Human adenovirus early region 4 open reading frame 1 genes encode growth-transforming proteins that may be distantly related to dUTP pyrophosphatase enzymes.." J. Virol.. 1997 Mar;71(3):1857-70. Pubmed PMID: 9032316
- Lawton JA, Estes MK, Prasad BV "Identification and characterization of a transcription pause site in rotavirus.." J. Virol.. 2001 Feb;75(4):1632-42. Pubmed PMID: 11160661
- Rahman GM, Shanker S, Lewin NE, Kedei N, Hill CS, Prasad BV, Blumberg PM, Das J "Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ).." Biochem. J.. 2013 Jul 1;453(1):153. Pubmed PMID: 23763314
- Rahman GM, Shanker S, Lewin NE, Kedei N, Hill CS, Prasad BV, Blumberg PM, Das J "Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ).." Biochem. J.. 2013 Apr 1;451(1):33-44. Pubmed PMID: 23289588
- Deng L, Diao J, Chen P, Pujari V, Yao Y, Cheng G, Crick DC, Prasad BV, Song Y "Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies.." J. Med. Chem.. 2011 Jul 14;54(13):4721-34. Pubmed PMID: 21561155
- Feng N, Lawton JA, Gilbert J, Kuklin N, Vo P, Prasad BV, Greenberg HB "Inhibition of rotavirus replication by a non-neutralizing, rotavirus VP6-specific IgA mAb.." J. Clin. Invest.. 2002 May;109(9):1203-13. Pubmed PMID: 11994409
- Chen R, Neill JD, Noel JS, Hutson AM, Glass RI, Estes MK, Prasad BV "Inter- and intragenus structural variations in caliciviruses and their functional implications.." J. Virol.. 2004 Jun;78(12):6469-79. Pubmed PMID: 15163740
- Nason EL, Rothagel R, Mukherjee SK, Kar AK, Forzan M, Prasad BV, Roy P "Interactions between the inner and outer capsids of bluetongue virus.." J. Virol.. 2004 Aug;78(15):8059-67. Pubmed PMID: 15254177
- Prasad BV, Burns JW, Marietta E, Estes MK, Chiu W "Localization of VP4 neutralization sites in rotavirus by three-dimensional cryo-electron microscopy.." Nature. 1990 Feb 1;343(6257):476-9. Pubmed PMID: 2153941
- Lawton JA, Estes MK, Prasad BV "Mechanism of genome transcription in segmented dsRNA viruses.." Adv. Virus Res.. 2000;55:185-229. Pubmed PMID: 11050943
- Guevara J, Knapp RD, Spurlino J, Prasad BV, Morrisett JD "Method for calculating 3-D coordinates from molecular stereograms.." J. Protein Chem.. 1992 Dec;11(6):653-6. Pubmed PMID: 1281634
- Horton LB1, Shanker S, Mikulski R, Brown NG, Phillips KJ, Lykissa E, Venkataram Prasad BV, Palzkill T. "Mutagenesis of zinc ligand residue Cys221 reveals plasticity in the IMP-1 metallo-β-lactamase active site." Antimicrob Agents Chemother.. 2012;56(11):5667-77. Pubmed PMID: 22908171
- Estes MK, Prasad BV, Atmar RL "Noroviruses everywhere: has something changed?." Curr. Opin. Infect. Dis.. 2006 Oct;19(5):467-74. Pubmed PMID: 16940871
- Shoemaker GK, van Duijn E, Crawford SE, Uetrecht C, Baclayon M, Roos WH, Wuite GJ, Estes MK, Prasad BV, Heck AJ "Norwalk virus assembly and stability monitored by mass spectrometry.." Mol. Cell Proteomics. 2010 Aug;9(8):1742-51. Pubmed PMID: 20418222
- Vongpunsawad S1, Venkataram Prasad BV, Estes MK. "Norwalk virus minor capsid protein VP2 associates within the VP1 shell domain." J Virol. 2013 May;87(9):4818-25.
- Pesavento JB, Crawford SE, Roberts E, Estes MK, Prasad BV "pH-induced conformational change of the rotavirus VP4 spike: implications for cell entry and antibody neutralization.." J. Virol.. 2005 Jul;79(13):8572-80. Pubmed PMID: 15956598
- Chiu W, Jeng TW, Degn LL, Prasad BV "Potential for high-resolution electron crystallography at intermediate high voltage.." Ann. N. Y. Acad. Sci.. 1986;483:149-56. Pubmed PMID: 3471122
- Baclayon M, Shoemaker GK, Uetrecht C, Crawford SE, Estes MK, Prasad BV, Heck AJ, Wuite GJ, Roos WH "Prestress strengthens the shell of norwalk virus nanoparticles.." Nano Lett.. 2011 Nov 9;11(11):4865-9. Pubmed PMID: 21967663
- Guevara J, Spurlino J, Jan AY, Yang CY, Tulinsky A, Prasad BV, Gaubatz JW, Morrisett JD "Proposed mechanisms for binding of apo[a] kringle type 9 to apo B-100 in human lipoprotein[a].." Biophys. J.. 1993 Mar;64(3):686-700. Pubmed PMID: 8386013
- Zhou ZH, Prasad BV, Jakana J, Rixon FJ, Chiu W "Protein subunit structures in the herpes simplex virus A-capsid determined from 400 kV spot-scan electron cryomicroscopy.." J. Mol. Biol.. 1994 Sep 30;242(4):456-69. Pubmed PMID: 7932703
- Clark KM, Wetzel JD, Gu Y, Ebert DH, McAbee SA, Stoneman EK, Baer GS, Zhu Y, Wilson GJ, Prasad BV, Dermody TS "Reovirus variants selected for resistance to ammonium chloride have mutations in viral outer-capsid protein sigma3.." J. Virol.. 2006 Jan;80(2):671-81. Pubmed PMID: 16378970
- Carpio RV, González-Nilo FD, Jayaram H, Spencer E, Prasad BV, Patton JT, Taraporewala ZF "Role of the histidine triad-like motif in nucleotide hydrolysis by the rotavirus RNA-packaging protein NSP2.." J. Biol. Chem.. 2004 Mar 12;279(11):10624-33. Pubmed PMID: 14699117
- Li Z, Baker ML, Jiang W, Estes MK, Prasad BV "Rotavirus architecture at subnanometer resolution.." J. Virol.. 2009 Feb;83(4):1754-66. Pubmed PMID: 19036817
- Baker M, Prasad BV "Rotavirus cell entry.." Curr. Top. Microbiol. Immunol.. 2010;343:121-48. Pubmed PMID: 20397068
- Hu L, Crawford SE, Hyser JM, Estes MK, Prasad BV "Rotavirus non-structural proteins: structure and function.." Curr Opin Virol. 2012 Aug;2(4):380-8. Pubmed PMID: 22789743
- Jayaram H, Taraporewala Z, Patton JT, Prasad BV "Rotavirus protein involved in genome replication and packaging exhibits a HIT-like fold.." Nature. 2002 May 16;417(6886):311-5. Pubmed PMID: 12015608
- Pesavento JB, Crawford SE, Estes MK, Prasad BV "Rotavirus proteins: structure and assembly.." Curr. Top. Microbiol. Immunol.. 2006;309:189-219. Pubmed PMID: 16913048
- Shaw AL, Rothnagel R, Zeng CQ, Lawton JA, Ramig RF, Estes MK, Prasad BV "Rotavirus structure: interactions between the structural proteins.." Arch. Virol. Suppl.. 1996;12:21-7. Pubmed PMID: 9015098
- Yao Y, Chen P, Diao J, Cheng G, Deng L, Anglin JL, Prasad BV, Song Y "Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies.." J. Am. Chem. Soc.. 2011 Oct 26;133(42):16746-9. Pubmed PMID: 21936531
- Prasad BV, Chiu W "Sequence comparison of single-stranded DNA binding proteins and its structural implications.." J. Mol. Biol.. 1987 Feb 5;193(3):579-84. Pubmed PMID: 3295261
- Shanker S1, Czako R, Sankaran B, Atmar RL, Estes MK, Prasad BV. "Structural Analysis of Determinants to HBGA Binding Specificity in GI Noroviruses." J. Virol.. 2014 Mar 19; Pubmed PMID: 24648450
- Brown NG, Shanker S, Prasad BV, Palzkill T "Structural and biochemical evidence that a TEM-1 beta-lactamase N170G active site mutant acts via substrate-assisted catalysis.." J. Biol. Chem.. 2009 Nov 27;284(48):33703-12. Pubmed PMID: 19812041
- Shanker, S., Czakó, R., Sapparapu, G., Alvarado, G., Viskovska, M., Sankaran, B., Atmar, R.L., Crowe, J.E. Jr., Estes, M.K., Prasad, B.V.V. "Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody.." Proc Natl Acad Sci U S A.. 2016;113:E5830-E5837. Pubmed PMID: 27647885
- Hu, L., Ramani, S., Czako, R., Sankaran, B., Yu, Y, Smith, D.F., Cummings, R.D., Estes, M.K. and Prasad, B.V.V. "Structural basis of glycan specificity in a neonate-specific bovine-human rotavirus reassortant.." Nature Communications. 2015;6:8346. Pubmed PMID: 26420502
- Muhaxhiri Z, Deng L, Shanker S, Sankaran B, Estes MK, Palzkill T, Song Y, Prasad BV "Structural basis of substrate specificity and protease inhibition in Norwalk virus.." J. Virol.. 2013 Apr;87(8):4281-92. Pubmed PMID: 23365454
- Paredes AM, Heidner H, Thuman-Commike P, Prasad BV, Johnston RE, Chiu W "Structural localization of the E3 glycoprotein in attenuated Sindbis virus mutants.." J. Virol.. 1998 Feb;72(2):1534-41. Pubmed PMID: 9445057
- Dormitzer PR, Nason EB, Prasad BV, Harrison SC "Structural rearrangements in the membrane penetration protein of a non-enveloped virus.." Nature. 2004 Aug 26;430(7003):1053-8. Pubmed PMID: 15329727
- Bertolotti-Ciarlet A, White LJ, Chen R, Prasad BV, Estes MK "Structural requirements for the assembly of Norwalk virus-like particles.." J. Virol.. 2002 Apr;76(8):4044-55. Pubmed PMID: 11907243
- Schmid MF, Prasad BV, Chiu W "Structural studies of viruses by electron cryomicroscopy.." Arch. Virol. Suppl.. 1994;9:523-9. Pubmed PMID: 8032281
- Prasad BV, Crawford S, Lawton JA, Pesavento J, Hardy M, Estes MK "Structural studies on gastroenteritis viruses.." Novartis Found. Symp.. 2001;238:26-37; discussi. Pubmed PMID: 11444031
- Prasad BV, Hardy ME, Jiang X, Estes MK "Structure of Norwalk virus.." Arch. Virol. Suppl.. 1996;12:237-42. Pubmed PMID: 9015120
- Prasad BV, Chiu W "Structure of rotavirus.." Curr. Top. Microbiol. Immunol.. 1994;185:41546. Pubmed PMID: 8050286
- Taraporewala ZF, Jiang X, Vasquez-Del Carpio R, Jayaram H, Prasad BV, Patton JT "Structure-function analysis of rotavirus NSP2 octamer by using a novel complementation system.." J. Virol.. 2006 Aug;80(16):7984-94. Pubmed PMID: 16873255
- Pesavento JB, Billingsley AM, Roberts EJ, Ramig RF, Prasad BV "Structures of rotavirus reassortants demonstrate correlation of altered conformation of the VP4 spike and expression of unexpected VP4-associated phenotypes.." J. Virol.. 2003 Mar;77(5):3291-6. Pubmed PMID: 12584352
- Deng L1, Muhaxhiri Z, Estes MK, Palzkill T, Prasad BV, Song Y. "Synthesis, Activity and Structure-Activity Relationship of Noroviral Protease Inhibitors.." Medchemcomm. 2013;4(10) Pubmed PMID: 24244836
- Chiu W, Schmid MF, Prasad BV "Teaching electron diffraction and imaging of macromolecules.." Biophys. J.. 1993 May;64(5):1610-25. Pubmed PMID: 8324196
- Carrillo B1, Choi JM, Bornholdt ZA, Sankaran B, Rice AP, Prasad BV. "The influenza A virus protein NS1 displays structural polymorphism." J Virol. 2014 Apr;88(8):4113-22. Pubmed PMID: 24478439
- Prasad BV, Balaram P "The stereochemistry of peptides containing alpha-aminoisobutyric acid.." CRC Crit. Rev. Biochem.. 1984;16(4):307-48. Pubmed PMID: 6389004
- Hill CL, Booth TF, Prasad BV, Grimes JM, Mertens PP, Sutton GC, Stuart DI "The structure of a cypovirus and the functional organization of dsRNA viruses.." Nat. Struct. Biol.. 1999 Jun;6(6):565-8. Pubmed PMID: 10360362
- Shaw AL, Samal SK, Subramanian K, Prasad BV "The structure of aquareovirus shows how the different geometries of the two layers of the capsid are reconciled to provide symmetrical interactions and stabilization.." Structure. 1996 Aug 15;4(8):957-67. Pubmed PMID: 8805574
- Ramani S, Cortes-Penfield NW, Hu L, Crawford SE, Czako R, Smith DF, Kang G, Ramig RF, Le Pendu J, Prasad BV, Estes MK "The VP8* Domain of Neonatal Rotavirus Strain G10P[11] Binds to Type II Precursor Glycans.." J. Virol.. 2013 Jul;87(13):7255-64. Pubmed PMID: 23616650
- Ramani S1, Cortes-Penfield NW, Hu L, Crawford SE, Czako R, Smith DF, Kang G, Ramig RF, Le Pendu J, Prasad BV, Estes MK. "The VP8* of neonatal rotavirus strain G10P[11] binds to type II precursor glycans." J Virol. 2013 Jul;87(13):7255-64. Pubmed PMID: 23616650
- Lawton JA, Zeng CQ, Mukherjee SK, Cohen J, Estes MK, Prasad BV "Three-dimensional structural analysis of recombinant rotavirus-like particles with intact and amino-terminal-deleted VP2: implications for the architecture of the VP2 capsid layer.." J. Virol.. 1997 Oct;71(10):7353-60. Pubmed PMID: 9311813
- Paredes AM, Brown DT, Rothnagel R, Chiu W, Schoepp RJ, Johnston RE, Prasad BV "Three-dimensional structure of a membrane-containing virus.." Proc. Natl. Acad. Sci. U.S.A.. 1993 Oct 1;90(19):9095-9. Pubmed PMID: 8415660
- Prasad BV, Rothnagel R, Jiang X, Estes MK "Three-dimensional structure of baculovirus-expressed Norwalk virus capsids.." J. Virol.. 1994 Aug;68(8):5117-25. Pubmed PMID: 8035511
- Prasad BV, Matson DO, Smith AW "Three-dimensional structure of calicivirus.." J. Mol. Biol.. 1994 Jul 15;240(3):256-64. Pubmed PMID: 8028008
- Prasad BV, Wang GJ, Clerx JP, Chiu W "Three-dimensional structure of rotavirus.." J. Mol. Biol.. 1988 Jan 20;199(2):269-75. Pubmed PMID: 2832610
- Thuman-Commike PA, Greene B, Jakana J, Prasad BV, King J, Prevelige PE, Chiu W "Three-dimensional structure of scaffolding-containing phage p22 procapsids by electron cryo-microscopy.." J. Mol. Biol.. 1996 Jul 5;260(1):85-98. Pubmed PMID: 8676394
- Prasad BV, Yamaguchi S, Roy P "Three-dimensional structure of single-shelled bluetongue virus.." J. Virol.. 1992 Apr;66(4):2135-42. Pubmed PMID: 1312624
- Schrag JD, Prasad BV, Rixon FJ, Chiu W "Three-dimensional structure of the HSV1 nucleocapsid.." Cell. 1989 Feb 24;56(4):651-60. Pubmed PMID: 2537151
- Prasad BV, Prevelige PE, Marietta E, Chen RO, Thomas D, King J, Chiu W "Three-dimensional transformation of capsids associated with genome packaging in a bacterial virus.." J. Mol. Biol.. 1993 May 5;231(1):65-74. Pubmed PMID: 8496966
Memberships
- American Crystallographic Association
- Member (01/2014)
- American Society of Virology
- Member (01/2014)
- Biophysical Society of America
- Member (01/2014)
- American Society of Microbiology
- Member (01/2014)
- American Association for the Advancement of Science
Skills
- X-ray Crystallography
- Cryo-EM
- Computational Biology
- Cell culture
- Protein Purification
- Biophysical Chemistry
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