Positions
- Professor
-
Medicine
Baylor College of Medicine
- Co-Director of Cancer Bioinformatics
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
- Affiliated Faculty Member
-
Human Genome Sequencing Center
Baylor College of Medicine
Education
- PhD from University Of Michigan
- 06/2006 - Ann Arbor, Michigan United States
- Bioinformatics
- BS from University of Idaho
- 05/1996 - Moscow, Idaho United States
- Physics
Professional Interests
- Understanding the molecular basis of cancer through genomics and proteomics
- Integrative analysis of diverse molecular data types
- Mining public genomic databases
- Noncoding somatic DNA alterations
Professional Statement
My focus is on bioinformatics analysis of molecular profiling data, which may include mRNA expression, microRNA expression, protein expression, DNA methylation, or DNA copy number. Fundamentally, my work seeks to obtain meaningful information from large-scale molecular datasets regarding questions relevant to improving cancer diagnosis and treatment. This often involves integration of molecular profiling results from different sources. Among other things, I have participated extensively in The Cancer Genome Atlas (TCGA), Pan-Cancer Analysis of Whole Genomes (PCAWG), and Children's Brain Tumor Network (CBTN) consortiums, multi-institutional efforts to systematically characterize the genomic changes that occur in cancer.Websites
Selected Publications
- Davis CF, Ricketts CJ, Wang M, Yang L, ..., Rathmell WK, Creighton CJ "The somatic genomic landscape of chromophobe renal cell carcinoma.." Cancer Cell. 2014;26(3):319-30. Pubmed PMID: 25155756
- Zhang Y, Kwok-Shing Ng P, Kucherlapati M, Chen F, …, Park PJ, Kucherlapati R, Scott KL, Mills GB, Kwiatkowski DJ, Creighton CJ "A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations." Cancer Cell. 2017 May 8;31(6):820-832. Pubmed PMID: 28528867
- Chen F, Zhang Y, Sxenbabaoglu Y, Ciriello G, Yang L, Reznik E, …, Choueiri TK, Hsieh JJ, Akbani R, Mills GB, Hakimi AA, Wheeler DA, Creighton CJ "Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma." Cell Rep. 2016 Mar 2;14(10):2476-89. Pubmed PMID: 26947078
- Zhang Y, Yang L, Kucherlapati M, Hadjipanayis A, Pantazi A, Bristow CA, Lee EA, Mahadeshwar HS, Tang J, Zhang J, Seth S, Lee S, Ren X, Song X, Sun H, Seidman J, Luquette LJ, Xi R, Chin L, Protopopov A, Park PJ, Kucherlapati R, Creighton CJ "Global impact of somatic structural variation on the DNA methylome of human cancers." Genome Biol. 2019;20(1):209. Pubmed PMID: 31610796
- Chen F, Chandrashekar DS, Varambally S, Creighton CJ "Pan-cancer molecular subtypes revealed by mass-spectrometry-based proteomic characterization of more than 500 human cancers." Nat Commun. 2019;10(1):5679. Pubmed PMID: 31831737
- Zhang Y, Yang L, Kucherlapati M, ..., Creighton CJ "A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases." Cell Rep. 2018;24(2):515-527. Pubmed PMID: 29996110
- Zhang Y, Chen F, ...,PCAWG Transcriptome Working Group, PCAWG Structural Variation Working Group, Creighton CJ "High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations." Nat Commun. 2020;11(1):736. Pubmed PMID: 32024823
- Chen F, Zhang Y, Gibbons DL, Deneen B, Kwiatkowski DJ, Ittmann M, Creighton CJ "Pan-cancer molecular classes transcending tumor lineage across 32 cancer types, multiple data platforms, and over 10,000 cases." Clin Cancer Res. 2018;24(9):2182-2193. Pubmed PMID: 29440175
- Tan X, Banerjee P, ..., Creighton CJ*, Glenn JS*, Kurie JM* "PI4KIIIβ is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma." Sci Transl Med. 2020;10(1):5679. Pubmed PMID: 31969487
- John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ*, Deneen B* "Identification of diverse astrocyte populations and their malignant analogs." Nat Neurosci. 2017;20(3):396-405. Pubmed PMID: 28166219
- Zhang Y, Chen F, Donehower LA, Scheurer ME, Creighton CJ "A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement." Nat Commun. 2021;12(1):937. Pubmed PMID: 33568653
- Zhang Y, Chen F, Chandrashekar DS, Varambally S, Creighton CJ "Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways." Nat Commun. 2022;13(1):2669. Pubmed PMID: 35562349
- Zhang Y, Chen F, Creighton CJ "Pan-cancer molecular subtypes of metastasis reveal distinct and evolving transcriptional programs." Cell Rep Med. 2023 Feb 1; Pubmed PMID: 36731467
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