Email

dwparson@bcm.edu

Positions

Associate Professor

Pediatrics-Oncology
Baylor College of Medicine
Houston, TX US

Associate Professor

Molecular and Human Genetics
Baylor College of Medicine

Associate Professor

BCM Human Genome Sequencing Center
Baylor College of Medicine

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Addresses

Texas Children's Hospital, Clinical Care Center (Clinic)

6701 Fannin St., 14th floor
Houston, TX 77030
United States
Phone: (832) 822-4242

Education

MD from Ohio State University College Of Medicine

01/2001 - Columbus, OH United States

PhD from Ohio State University College Of Medicine

01/1999 - Columbus, Ohio United States

Pathology

Residency at Johns Hopkins University School Of Medicine

01/2004 - Baltimore, Maryland United States

Pediatrics

Clinical Fellowship at National Cancer Institute

01/2007 - Bethesda, Maryland United States

Pediatric Hematology-Oncology

Clinical Fellowship at Johns Hopkins University

01/2008 - Baltimore, Maryland United States

Neuro-Oncology

Professional Interests

• Clinical application of genome sequencing in pediatric cancer care
• Molecular characterization of pediatric cancers

Professional Statement

Dr. Parsons is a board-certified pediatric hematologist-oncologist specializing in the care of children with high risk cancers, including brain and spinal cord tumors. He serves as the Deputy Director of the Texas Children's Cancer and Hematology Center (TXCH) and the Co-Director of the TXCH Cancer Genetics & Genomics Program.

His research program primarily focuses on the clinical application of genomic technologies in pediatric cancer care and the use of these methods to characterize the molecular basis of pediatric cancers. Over the past decade Dr. Parsons has served as the principal investigator for seminal studies evaluating the use of clinical genomic testing for childhood cancer patients as part of the NHGRI Clinical Sequencing Evidence-Generating Research (CSER) program. He has a particular interest in the development and evaluation of molecular targeted therapies and has a number of leadership roles in this area including serving as the Children's Oncology Group (COG) study chair for the ongoing NCI-COG Pediatric MATCH trial, the first nationwide precision oncology trial for children and young adults with treatment refractory cancers.

Websites

Selected Publications

• Scollon S, Bergstrom K, Kerstein RA, Wang T, Hilsenbeck SG, Ramamurthy U, Gibbs RA, Eng CM, Chintagumpala MM, Berg SL, McCullough LB, McGuire AL, Plon SE, Parsons DW "Obtaining informed consent for clinical tumor and germline exome sequencing of newly diagnosed childhood cancer patients." Genome Med.. 2014 Sep 17;6(9):69. Pubmed PMID: 25317207
• Chakraborty R, Hampton OA, Shen X, et al "Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis." Blood. 2014 Sep 8;124(9):3007-15. Pubmed PMID: 25202140
• Parsons DW, Li M, Zhang X, et al "The genetic landscape of the childhood cancer medulloblastoma." Science. 2011 Jan 28;331(6016):435-9. Pubmed PMID: 21163964
• Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD "IDH1 and IDH2 mutations in gliomas." N Engl J Med. 2009 Feb 19;360(8):765-73. Pubmed PMID: 19228619