Gretchen Diehl, Ph.D.
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Gretchen Diehl, Ph.D.
Assistant Professor
Positions
- Assistant Professor
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Molecular Virology & Microbiology
Alkek Center for Metagenomics and Microbiome Research
Baylor College of Medicine
Houston, TX US
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
- Co-Director
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Biology of Inflammation Center
Addresses
- BCM DeBakey (Lab)
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Room: BCM-M904
Houston, TX 77030
United States
Phone: (713) 798-8071
Education
- Post-Doctoral Fellowship at NYU School of Medicine
- New York, New York United States
- PhD from University of California, Berkeley
- Berkeley, California United States
- Molecular and Cell Biology
- BA from Pomona College
- Claremont, California United States
Professional Interests
- Impact of the microbiota on intestinal immune responses
Professional Statement
The lab’s focus is the crosstalk between the intestinal immune system and the microbiota. We previously determined that signals from the microbiota promote intestinal homeostasis by both facilitating mucosal healing and limiting the induction of inflammatory immune responses against intestinal antigens. We are now examining the specific microbes involved in these processes as well as identifying the signaling pathways mediating these responses. This will allow selective manipulation of the intestinal immune system to either increase immune responses (in the case of infectious diseases) or limit them (in the case of inflammatory disorders such as IBD).Websites
Selected Publications
- Kim M, Galan C, Hill AA, Wu WJ, Fehlner-Peach H, Song HW, Schady D, Bettini ML, Simpson KW, Longman RS, Littman DR, Diehl GE "Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses." Immunity. 2018; Pubmed PMID: 29980437
- Longman RS, Diehl GE, Victorio DA, Huh JR, Galan C, Miraldi ER, Swaminath A, Bonneau R, Scherl EJ, Littman DR "CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22." J Exp Med. 2014 Jul 28;211(8):1571-83. Pubmed PMID: 25024136
- Diehl GE, Longman RS, Zhang JX, Breart B, Galan C, Cuesta A, Schwab SR, Littman DR "Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells." Nature. 2013 Feb 7;494(7435):116-20. Pubmed PMID: 23334413
- Longman RS, Yang Y, Diehl GE, Kim SV, Littman DR "Microbiota: host interactions in mucosal homeostasis and systemic autoimmunity." Cold Spring Harb Symp Quant Biol.. 2013;78:193-201. Pubmed PMID: 24913313
- Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, Flavell RA, Littman DR, Pamer EG "Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense." Immunity. 2012 Feb 24;36(2):276-87. Pubmed PMID: 22306017
- Valdez Y, Diehl GE, Vallance BA, Grassl GA, Guttman JA, Brown NF, Rosenberger CM, Littman DR, Gros P, Finlay BB "Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection." Cell Microbiol.. 2008 Aug;10(8):1646-61. Pubmed PMID: 18397382
- Zhang JX, Diehl GE, Littman DR "Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells." PLoS One. 2008 Apr 30;3(4):e2035. 2008 Apr 30;3(4):e2035. Pubmed PMID: 18446227
- Diehl GE, Yue HH, Hsieh K, Kuang AA, Ho M, Morici LA, Lenz LL, Cado D, Riley LW, Winoto A "TRAIL-R as a negative regulator of innate immune cell responses." Immunity. 2004 Dec;21(6):877-89. 2004 Dec;21(6):877-89. Pubmed PMID: 15589175
- Kuang AA, Diehl GE, Zhang J, Winoto A "FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts." J Biol Chem. 2000 Aug;275(33):25065-8. Pubmed PMID: 10862756
- Osborn SL, Diehl G, Han SJ, Xue L, Kurd N, Hsieh K, Cado D, Robey EA, Winoto A "Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis." Proc Natl Acad Sci. 2010 Jul 20;107(29):13034-9. Pubmed PMID: 20615958
- Yue HH, Diehl GE, Winoto A "Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice." Cell Death Differ. 2005 Jan;12(1):94-7. Pubmed PMID: 15514675
- Ivanov II, Diehl GE, Littman DR "Lymphoid tissue inducer cells in intestinal immunity." Curr Top Microbiol Immunol.. 2006;308:59-82. Pubmed PMID: 16922086
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