Email

jianchang.yang@bcm.edu

Positions

Associate Professor of Surgery

Division of Cardiothoracic Surgery
Baylor College of Medicine

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Addresses

Alkek Building for Biomedical Research (Lab)

One Baylor Plaza
Suite 411
Houston, TX 77030
United States

Education

PhD from Charité University Medicine Berlin

Berlin

MS from Sun Yat-sen University of Medical Sciences

Guangzhou

MD from XinJiang University

Urumqi

Honors & Awards

“Super Scientist” Recognition Award

Epigentek Group Inc.

Research Scholar Grant

American Cancer Society

Scholar Award

American Society of Hematology

LLS Special Fellowship

The Leukemia & Lymphoma Society

Professional Interests

• Cardiac progenitor regulation and direct cellular reprogramming
• epigenetic mechanisms of gene expression
• Normal and leukemic hematopoietic stem cell regulation
• Embryonic stem cells (ESCs)
• Generation of patient-specific pluripotent progenitor cells (iPS) for clinical therapies

Professional Statement

Jianchang Yang received his MD from XinJiang University of Medical Sciences, MS of Medical Biochemistry from Sun Yat-sen University in China, and his degree in Molecular Cardiology from Charite University Medicine (Berlin)-magna cum laude. His research interests include normal and leukemic hematopoietic stem cell regulation, cardiac progenitor cell and cellular reprogramming, epigenetic control of gene expression, ES cells, generation of patient-specific pluripotent progenitor cells for clinical therapies.

Websites

Selected Publications

• Liu L, Liu L, Leung L, Cooney A, Chen C, Rosengart T, Ma Y, Yang J "Knockdown of SALL4 enhances all-trans retinoic acid-induced cellular differentiation in acute myeloid leukemia cells." J Biol Chem.; Pubmed PMID: 25737450
• Mathison M, Singh VP, Gersch RP, Ramirez MO, Cooney A, Kaminsky SM, Chiuchiolo MJ, Nasser A, Yang J, Crystal RG, Rosengart TK ""Triplet" polycistronic vectors encoding Gata4, Mef2c, and Tbx5 enhances postinfarct ventricular functional improvement compared with singlet vectors." J Thorac Cardiovasc Surg.; Pubmed PMID: 24755332
• Liu L, Souto J, Liao W, Jiang Y, Li Y, Nishinakamura R, Huang S, Rosengart T, Yang VW, Schuster M, Ma Y, Yang J "Histone Demethylase LSD1 is Involved in SALL4 Mediated Transcriptional Repression in Hematopoietic Stem Cells." J Biol Chem.; Pubmed PMID: 24163373
• Mathison M, Gersch R, Nasser A, Lilo S, Korman M, Fourman M, Hackett N, Yang J, Shroyer K, Ma Y, Crystal R, Rosengart T "In Vivo Cardiac Cellular Reprogramming Efficacy is Enhanced by Angiogenic Preconditioning of the Infarcted Myocardium with Vascular Endothelial Growth Factor." J Am Heart Assoc.; Pubmed PMID: 23316332