Email

splon@bcm.edu

Positions

Professor

Molecular and Human Genetics
Baylor College of Medicine

Dan L. Duncan Comprehensive Cancer Center Professorship

Pediatrics-Oncology
Baylor College of Medicine
Houston, TX US

Assistant Dean

Dual Degree Programs and Pathways, School of Medicine
Baylor College of Medicine

Co-Leader, Pediatric Cancer Program

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Director

Cancer Genetics Clinical and Research Programs
Texas Children's Hospital

Addresses

Texas Children's Cancer Genetics Clinic (Clinic)

Mark Wallace Tower
6701 Fannin Street, 14th Floor
Houston, TX 77030
United States
Phone: (832) 822-4240
Texas Children's Cancer Genetic Clinic

Education

Postdoctoral Fellowship at Fred Hutchinson Cancer Research Center

06/1993 - Seattle, Washington United States

Medical Genetics, Cancer Genetics

Clinical Fellowship at University Of Washington Affiliate Hospitals

06/1993 - Seattle, Washington United States

Medical Genetics

Postdoctoral Fellowship at National Cancer Institute

06/1989 - Bethesda, Maryland United States

Cancer Genetics

Residency at University Of Washington Affiliate Hospitals

06/1988 - Seattle, Washington United States

Internal Medicine

MD from Harvard Medical School

01/1987 - Boston, MA United States

PhD from Harvard University

05/1987 - Cambridge, MA United States

Biophysics

BS from Massachusetts Institute Of Technology

05/1979 - Cambridge, MA United States

Chemistry

Certifications

Clinical Genetics

American Board of Medical Genetics

Professional Interests

• Cancer predisposition syndromes

Professional Statement

I have had a longstanding focus on the fields of cancer genetics and clinical genomics. My translational research is designed to understand mechanisms of susceptibility to pediatric cancer through large collaborative projects. We have worked closely with Dr. Philip Lupo on a landmark study of the association of birth defects and childhood cancer and are now using whole genome sequencing of these unique patients to identify novel cancer susceptibility genes as well as laboratory research to understand the hereditary basis of rhabdomyosarcoma, an often-lethal tumor in children. I serve as co-PI with Donald (Will) Parsons and Amy McGuire on the NHGRI/NCI- U01 Texas KidsCanSeq trial that studies the incorporation of CLIA clinical genome-scale exome sequencing into the care of childhood cancer patients (solid tumors and brain tumors) in the diverse patient populations across six sites in Texas. I am one of the principal investigators of the Clinical Genome Resource (ClinGen), an international effort dedicated to building a central resource that defines the clinical relevance of genes and variants for use in precision medicine and research.

Websites

Selected Publications

• Li H, Sisoudiya SD, Martin-Giacalone BA, Khayat MM, Dugan-Perez S, (…), Plon SE, Sabo A, Lupo PJ "Germline Cancer Predisposition Variants in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group." J Natl Cancer Inst.. 2021;113:875-883. Pubmed PMID: 33372952
• Lupo PJ, Schraw JM, Desrosiers TA, Nembhard WN, Langlois PH, (…), Plon SE "Association Between Birth Defects and Cancer Risk Among Children and Adolescents in a Population-Based Assessment of 10 Million Live Births.." JAMA Oncol.. 2019;5:1150-1158. Pubmed PMID: 31219523
• Parsons DW, Roy A, Yang Y, Wang T, Scollon S, Bergstrom K, (...), Eng CM, Gibbs RA, Plon SE "Diagnostic Yield of Clinical Tumor and Germline Whole-Exome Sequencing for Children With Solid Tumors.." JAMA Oncol.. 2016;2:616-624. Pubmed PMID: 26822237

Memberships

American Society of Human Genetics

Member (06/1990)

American Association of Cancer Research

Member (07/1995)

American College of Medical Genetics and Genomics

Fellow (06/1995)