Research

Genetically Engineered Rodent Models Publications

Master
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2022

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Savannah J. Lusk, Andrew McKinney, Patrick J. Hunt, Paul G. Fahey, Jay Patel, Andersen Chang, Jenny J. Sun, Vena K. Martinez, Ping Jun Zhu, Jeremy R. Egbert, Genevera Allen, Xiaolong Jiang, Benjamin R. Arenkiel, Andreas S. Tolias, Mauro Costa-Mattioli and Russell S. Ray, A CRISPR toolbox for generating intersectional genetic mouse models for functional, molecular, and anatomical circuit mapping, BMC Biol. 2022 Jan 28;20(1):28. doi: 10.1186/s12915-022-01227-0. PMID: 35086530

James P Orengo, Larissa Nitschke, Meike E van der Heijden, Nicholas A Ciaburri, Harry T Orr , Huda Y Zoghbi, Reduction of mutant ATXN1 rescues premature death in a conditional SCA1 mouse model, JCI Insight. 2022 Apr 22;7(8):e154442. PMID: 35290244

Eagle K, Jiang Y, Shi X, Li M, Obholzer ND, Hu T, Perez MW, Koren JV, Kitano A, Yi JS, Lin CY, Nakada D. An oncogenic enhancer encodes selective selenium dependency in AML. Cell Stem Cell. 2022 Apr 7;29(4):650. doi: 10.1016/j.stem.2022.03.006. PMID: 35395189
Zhou J, Hamdan H, Yalamanchili HK, Pang K, Pohodich AE, Lopez J, et al. Disruption of MeCP2–TCF20 complex underlies distinct neurodevelopmental disorders. Proc Natl Acad Sci. 2022;119 (4) e2119078119. PMID: 35074918

Chern T, Achilleos A, Tong X, Hill MC, Saltzman AB, Reineke LC, Chaudhury A, Dasgupta SK, Redhead Y, Watkins D, Neilson JR, Thiagarajan P, Green JBA, Malovannaya A, Martin JF, Rosenblatt DS, Poché RA. Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy. Nat Commun. 2022 Jan 10;13(1):134. doi: 10.1038/s41467-021-27759-7. PMID: 35013307
 

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2021

Content

Webster NJ, Maywald RL, Benton SM, Dawson EP, Murillo OD, LaPlante EL, Milosavljevic A, Lanza DG, Heaney JD. Testicular germ cell tumors arise in the absence of sex-specific differentiation. Development. 2021 May 1;148(9):dev197111. doi: 10.1242/dev.197111. Epub 2021 Apr 26. PMID: 33912935

Birling MC, Yoshiki A, Adams DJ, Ayabe S, Beaudet AL, Bottomley J, Bradley A, Brown SDM, Bürger A, Bushell W, Chiani F, Chin HG, Christou S, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Donahue LR, Fray MD, Gambadoro A, Gao X, Gertsenstein M, Gomez-Segura A, Goodwin LO, Heaney JD, Hérault Y, de Angelis MH, Jiang ST, Justice MJ, Kasparek P, King RE, Kühn R, Lee H, Lee YJ, Liu Z, Lloyd KCK, Lorenzo I, Mallon AM, McKerlie C, Meehan TF, Fuentes VM, Newman S, Nutter LMJ, Oh GT, Pavlovic G, Ramirez-Solis R, Rosen B, Ryder EJ, Santos LA, Schick J, Seavitt JR, Sedlacek R, Seisenberger C, Seong JK, Skarnes WC, Sorg T, Steel KP, Tamura M, Tocchini-Valentini GP, Wang CL, Wardle-Jones H, Wattenhofer-Donzé M, Wells S, Wiles MV, Willis BJ, Wood JA, Wurst W, Xu Y; International Mouse Phenotyping Consortium (IMPC), Teboul L, Murray SA. A resource of targeted mutant mouse lines for 5,061 genes. Nat Genet. 2021 Apr;53(4):416-419. doi: 10.1038/s41588-021-00825-y. PMID: 33833456

Huang YH, Chen CW, Sundaramurthy V, Słabicki M, Hao D, Watson CJ, Tovy A, Reyes JM, Dakhova O, Crovetti BR, Galonska C, Lee M, Brunetti L, Zhou Y, Tatton-Brown K, Huang Y, Cheng X, Meissner A, Valk PJM, Van Maldergem L, Sanders MA, Blundell JR, Li W, Ebert BL, Goodell MA. Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor. Cancer Discov. 2022 Jan;12(1):220-235. doi: 10.1158/2159-8290.CD-21-0560. Epub 2021 Aug 24. PMID: 34429321
 

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2020

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Stroup BM, Marom R, Li X, Hsu CW, Chang CY, Truong LD, Dawson B, Grafe I, Chen Y, Jiang MM, Lanza D, Green JR, Sun Q, Barrish JP, Ani S, Christiansen AE, Seavitt JR, Dickinson ME, Kheradmand F, Heaney JD, Lee B, Burrage LC. A global Slc7a7 knockout mouse model demonstrates characteristic phenotypes of human lysinuric protein intolerance. Hum Mol Genet. 2020 Aug 3;29(13):2171-2184. doi: 10.1093/hmg/ddaa107. PMID: 32504080

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2019

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Hai L, Szwarc MM, Lanza DG, Heaney JD, Lydon JP. Using CRISPR/Cas9 engineering to generate a mouse with a conditional knockout allele for the promyelocytic leukemia zinc finger transcription factor. Genesis. 2019 Mar;57(3):e23281. doi: 10.1002/dvg.23281. Epub 2019 Jan 23. PMID: 30628160