Email

ayrea.hurley@bcm.edu

Positions

Research Assistant II

Molec. Physiology/Lagor
Baylor College of Medicine
Houston, TX US

Education

BS from Abilene Christian University

05/2013 - Abilene, Texas United States

Chemistry

Professional Interests

• Adeno-Associated Viruses
• CRISPR-Cas9
• Somatic gene editing
• Gene therapy

Selected Publications

• Marco De Giorgi, Ang Li, Ayrea Hurley, Mercedes Barzi, Alexandria M Doerfler, Nikitha A Cherayil, Harrison E Smith, Jonathan D Brown, Charles Y Lin, Karl-Dimiter Bissig, Gang Bao, William R Lagor "Targeting the Apoa1 locus for liver-directed gene therapy." Mol Ther Methods Clin Dev.. 2021 Apr 24; Pubmed PMID: 34141821
• De Giorgi M, Jarrett KE, Burton JC, Doerfler AM, Hurley A, Li A, Hsu RH, Furgurson M, Patel KR, Han J, Borchers CH, Lagor WR. "Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase." J Lipid Res.. 2020 Dec; Pubmed PMID: 33109681
• Yelamanchili D, Liu J, Gotto AM Jr, Hurley AE, Lagor WR, Gillard BK, Davidson WS, Pownall HJ, Rosales C "Highly conserved amino acid residues in apolipoprotein A1 discordantly induce high density lipoprotein assembly in vitro and in vivo." 2020 Dec; Pubmed PMID: 32810603
• Ang Li, Mark R. Tanner, Ciaran M. Lee, Ayrea E. Hurley, Marco De Giorgi, Kelsey E. Jarrett, Timothy H. Davis, Alexandria M. Doerfler, Gang Bao, Christine Beeton, William R. Lagor "AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9." Mol. Ther.. 2020 Jun 3;