Richard
Middle Name
Aras (Aaron)
Cox, Ph.D.
Middle Name
Aras (Aaron)
Picture
Richard
Middle Name
Aras (Aaron)
Cox, Ph.D.
Middle Name
Aras (Aaron)
Instructor
Positions
- Instructor
-
Medicine
Endocrinology, Diabetes, and Metabolism
Baylor College of Medicine
Houston, TX US
Addresses
- BCM-Alkek Building for Biomedical Research (Lab)
-
One Baylor Plaza
Houston, TX 77030
United States
Education
- Postdoctoral Fellowship at Baylor College of Medicine
- 01/2019 - Houston
- Obesity, Metabolism, and Inflammation
- Postdoctoral Fellowship at Baylor College of Medicine
- 02/2018 - Houston
- Beta Cell Biology
- PhD from University of Western Ontario
- 06/2011 - London, ON Canada
- Physiology
- BSc from University of Western Ontario
- 06/2004 - London, ON Canada
- Physiology
Professional Interests
- Obesity and Insulin Resistance
- Immune Cell Metabolism
- Islet Biology
- Type 1 and 2 Diabetes
Professional Statement
Diabetes is marked by a relative or absolute deficiency of insulin-producing beta cells. Strategies to expand beta cell mass have significant potential to restore glucose control in diabetes patients. Beta cells demonstrate tremendous capacity to proliferate during obesity, although the mechanisms are unclear. We are focused on uncovering the hormonal and metabolic signals that drive beta cell expansion in obesity. In particular, we are examining the central and islet specific mechanisms by which leptin regulates beta cells proliferation. Our goal is to identify novel targets for the expansion of endogenous beta cells in patients with diabetes. We are employing new genetic mouse models, metabolic phenotyping, and molecular approaches to examine the effects of obesity-derived signals on beta cells.Websites
Selected Publications
- Hartig SM, Cox AR "Paracrine signaling in islet function and survival." Journal of Molecular Medicine.2020/April;98(4):451-467. Pubmed PMID: 32067063
- Cox AR, Chernis N, Masschelin PM, Hartig SM "Immune cells gate white adipose tissue expansion." Endocrinology.2019/July;160(7):1645-58. Pubmed PMID: 31107528
- Cox AR, Lam CJ, Rankin MM, Rios JS, Chavez J, Bonnyman CW, King KB, Wells RA, Anthony D, Tu JX, Kim JJ, Li C, Kushner JA "Incretin Therapies Do Not Expand beta-cell Mass or Alter Pancreatic Histology in Young Male Mice.." Endocrinology.2017/June;158(6):1701-14. Pubmed PMID: 28323942
- Cox AR, Lam CJ, Rankin MM, King KA, Chen P, Martinez R, Li C, Kushner JA "Extreme obesity induces massive beta cell expansion through self-renewal and does not alter the beta cell lineage." Diabetologia.2016/June;59(6):1231-41. Pubmed PMID: 27003683
- Cox AR, Barrandon O, Cai EP, Rios JS, Chavez J, Bonnyman CW, Lam CJ, Yi P, Melton DA, Kushner JA "Resolving discrepant findings on ANGPTL8 in beta cell proliferation: a collaborative approach to resolving the betatrophin controversy.." Plos One. 2016 July ; : Pubmed PMID: 27410263
- Masschelin PM, Cox AR, Chernis N, Hartig SM "The Impact of Oxidative Stress on Adipose Tissue Energy Balance." Frontiers in Physiology. 2020 January ; 10 : 1638. Pubmed PMID: 32038305
- Chernis N, Masschelin P, Cox AR, Hartig SM "Bisphenol AF promotes inflammation in human white adipocytes." Am J Physiol Cell Physiol. 2020 January ; 318 (1): C63-C72. Pubmed PMID: 31596606
- Zhang L, Sosinowski T, Cox AR, Cepeda JR, Sekhar NS, Hartig SM, Miao D, Yu L, Pietropaolo M, Davidson HW. "Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes." J Autoimmun. 2019 January ; 96 : 50-58. Pubmed PMID: 30122420
- Vonberg AD, Acevedo-Calado M, Cox AR, Pietropaolo SL, Gianani R, Lundy SK, Pietropaolo M "CD19+IgM+ cells demonstrate enhanced therapeutic efficacy in type 1 diabetes mellitus." JCI Insight. 2018 December 6; 3 (23): Pubmed PMID: 30518692
- Cox AR, Kushner JA. "Area IV Knockout Reveals How Pdx1 Is Regulated in Postnatal β-Cell Development." Diabetes. 2017 November ; 66 (11): 2738-2740. Pubmed PMID: 29061659
- Lam CJ, Chatterjee A, Shen E, Cox AR, Kushner JA "Low Level Insulin Content Within Abundant Non-Beta Islet Endocrine Cells in Long-Standing Type 1 Diabetes." Diabetes. 2018 December 14; : Pubmed PMID: 30552110
- Lam CJ, Cox AR, Jacobson DR, Rankin MM, Kushner JA "Highly Proliferative α-Cell-Related Islet Endocrine Cells in Human Pancreata." Diabetes. 2018 April ; 67 (4): 674-686. Pubmed PMID: 29326366
- Lam CJ, Jacobson DR, Rankin MM, Cox AR, Kushner JA "Beta-cells persist in T1D pancreata without evidence for ongoing beta-cell turnover or neogenesis.." J Clin Endocrinol Metab. 2017 August ; 102 (8): 2647-59. Pubmed PMID: 28323930
- Cox AR, Lam CJ, Bonnyman CW, Chavez J, Rios JS, Kushner JA "ANGPTL8/Betatrophin overexpression does not increase beta cell proliferation in mice.." Diabetologia. 2015 July ; 58 (7): 1523-31. Pubmed PMID: 25917759
- Shields EJ, Lam CJ, Cox AR, Rankin MM, Van Winkle TJ, Hess RS, Kushner JA "Extreme beta-cell deficiency in pancreata of dogs with canine diabetes.." Plos One. 2015 June ; 10 (6): Pubmed PMID: 26057531
- Cox AR, Beamish CA, Carter DE, Arany EJ, Hill DJ "Cellular mechanisms underlying failed beta cell regeneration in offspring of protein restricted pregnant mice.." Exp Biol Med (Maywood). 2013 October ; 238 (10): 1147-59. Pubmed PMID: 23986224
- Cox AR, Gottheil SK, Arany EJ, Hill DJ: "The effects of low protein exposure during gestation on mouse pancreatic development and beta cell regeneration.." Pediatr Res. 2010 July ; 68 (1): 16-22. Pubmed PMID: 20386490
Funding
- Re-purposing anti-rheumatic drugs to treat obesity BCM Center for Research in Obesity and Nutrition
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