Xu Lab Publications

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2024

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Tu L, Fang X, Yang Y, Yu M, Liu H, Liu H, Yin N, Bean JC, Conde KM, Wang M, Li Y, Ginnard OZ, Liu Q, Shi Y, Han J, Zhu Y, Fukuda M, Tong Q, Arenkiel B, Xue M, He Y, Wang C, Xu Y. Vestibular neurons link motion sickness, behavioral thermoregulation and metabolic balance. Nature Metabolism (in press).

Yuan Q, Zeng H, Daniel TC, Liu Q, Yang Y, Osikpa MC, Yang Q, Peddi A, Abramson LM, Zhang B, Xu Y, Gao X. Orthogonal and multiplexable genetic perturbations with an engineered prime editor and a diverse RNA array. Nature Communications (in press).

Francois M, Kaiser L, He Y, Xu Y, Salbaum JM, Yu S, Morrison CD, Berthoud HR, Münzberg H. Leptin receptor neurons in the dorsomedial hypothalamus require distinct neuronal subsets for thermogenesis and weight loss. Metabolism (in press).

Conde KM, Wong HZ, Fang S, Li Y, Yu M, Deng Y, Liu Q, Fang X, Wang M, Shi Y, Ginnard OZ, Yang Y, Tu L, Liu H, Liu H, Yin N, Bean JC, Han Y, Burt ME, Jossy SV, Yang Y, Tong Q, Arenkiel BR, Wang C, He Y, Xu Y. Serotonin neurons integrate GABA and dopamine inputs to regulate meal initiation. Metabolism (in press).

Moya-Garzon MD, Wang M, Li VL, Lyu X, Wei W, Tung AS, Raun SH, Zhao M, Coassolo L, Islam H, Oliveira B, Dai Y, Spaas J, Delgado-Gonzalez A, Donoso K, Alvarez-Buylla A, Franco-Montalban F, Letian A, Ward C, Liu L, Svensson KJ, Goldberg EL, Gardner CD, Little JP, Banik SM, Xu Y, Long JZ. A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites. Cell 2024 Nov 7:S0092-8674(24)01214-5. doi.org/10.1016/j.cell.2024.10.032. Online ahead of print.

Yu M, Yin N, Feng B, Gao P, Yu K, Liu H, Liu H, Li Y, Ginnard OZ, Conde KM, Wang M, Fang X, Tu L, Bean JC, Liu Q, Deng Y, Yang Y, Han J, Jossy SV, Burt ML, Wong HZ, Yang Y, Arenkiel BR, He Y, Guo S, Gourdy P, Arnal JF, Lenfant F, Wang Z, Wang C, He Y, Xu Y. Identification of an ionic mechanism for ERα-mediated rapid excitation in neurons. Science Advances 2024 Oct 4;10(40):eadp0696. doi: 10.1126/ sciadv. adp0696. Epub 2024 Oct 2.

Zhang N, Song B, Bai P, Du L, Chen L, Xu Y and Zeng T. Perineuronal nets' role in metabolism. American Journal of Physiology-Endocrinology and Metabolism 2024 Oct 1;327(4):E411-E421.doi: 10.1152/ajpendo.00154.2024. Epub 2024 Aug 14.

Liu H, Bean JC, Li Y, Yu M, Ginnard OZ, Conde KM, Wang M, Fang X, Liu H, Tu L, Yin N, Han J, Yang Y, Tong Q, Arenkiel BR, Wang C, He Y, Xu Y. A basal forebrain neural population promotes homeostatic feeding and suppresses hedonic feeding. Nature Metabolism August 7, 2024 (online). Highlighted by Nature Reviews Endocrinology.

Farooqi IS and Xu Y. Translational potential of mouse models of human metabolic disease. Cell July 26, 2024. DOI: https://doi.org/10.1016/j.cell.2024.07.011.

Li Y, Cacciottolo TM, Yin N, He Y, Liu H, Liu H, Yang Y, Henning E, Keogh JM, Lawler L, de Oliveira EM, Gardner EJ, Kentistou KA, Laouris P, Bounds R, Ong KK, Perry JRB, Barroso I, Tu L, Bean JC, Yu M, Conde KM, Wang M, Ginnard O, Fang X, Tong L, Han J, Darwich T, Williams KW, Yang Y, Wang C, Joss S, Firth HV, Xu Y, Farooq IS. Loss of transient receptor potential channel 5 causes obesity and postpartum depression. Cell Published: July 2, 2024. PMID: 38959890. dio: https://doi.org/10.1016/j.cell.2024/06.001.

Liu H, He Y, Liu H, Brouwers B, Yin N, Lawler K, Keogh JM, Henning E, Lee DK, Yu M, Tu L, Zhang N, Conde KM, Han J, Yan Z, Scarcelli NA, Liao L, Xu J, Tong Q, Zheng H, Sun Z, Yang Y, Wang C, He Y, Farooq IS, Xu Y. Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans. Science Advances 2024 Jun 28; 10(26);eadl2675. dio: 10.1126/sciadv.adl2675.Epub 2024 Jun 28.

Liu H, Qu N, Gonzalez NV, Palma MA, Chen H, Xiong J, Choubey A, Li Y, Li X, Yu M,
Liu H, Tu L, Zhang N, Yin N, Conde KM, Wang M, Bean JC, Han Y, Scarcelli NA, Yang Y, Saito K, Cui X, Tong Q, Sun Z, Wang C, Cai X, Lu L, He Y, Xu Y. A light responsive neural circuit suppresses feeding. Journal of Neuroscience 2024 Jun 19:e20192232024. PMID: 38897723. dio: 10.1523/JNEUROSCI.2192-23.2024.

Yang W, Jiang W, Liao Wang, Yan H, Ai W, Pan Q, Brashear WA, Xu Y, He L, Guo S. An estrogen receptor α-derived peptide improves glucose homeostasis during obesity.
Nature Communications 2024 Apr 22;15(1):3410. doi: 10.1038/s41467-024-47687-06. PMID: 38649684. PMCID: PMC11035554.

Edwards GA, Wood CA, He Y, Nguyen Q, Kim PJ, Gomez-Gutierrez R, Park KW, Xu Y, Zurhellen C, Al-Ramahi I, Jankowsky JL. TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy. Acta Neuropathologica 2024 Mar 25; 147(1):61. Dio: 10.1007/s00401-024-02701-5. PMID: 38526616.

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Archive

Cai J, Xu Y, Jiang Z, Jiang Y, Li H, Otiz-Guzman J, Xu Y, Arenkiel BR and Tong Q. An excitatory projection from the basal forebrain to the ventral tegmental area underlying anorexia-like phenotypes. Neuron 2023 Dec 1: S0896-6273(23)00845-0. Dio: 10.1016/j.neuron.2023.11.001. PMID: 38056455.

Tong L, Xu Y. Chronic stress adds fuel to gut flame. Obesity Medicine 2023 Dec, 100519. doi:10.1016/j.obmed.2023.100519.

Tu L, He Y, Xu Y. Anoctamin 4 defines glucose-inhibited neurons in the ventromedial hypothalamus. Neural Regeneration Research 2023; 19(6):p1177-1178. doi:10.4103/1673-5374.385867.

Xue Y, Gong Y, Li X, Peng F, Ding G, Zhang Z, Shi J, Savul IS, Xu Y, Chen Q, Han L, Mao S, Sun Z. Sex differences in paternal arsenic-induced intergenerational metabolic effects are mediated by estrogen. Cell & Bioscience 2023 Sep 10;13(1):165. doi: 10.1186/s13578-023-01121-4. PMID: 37691128. PMCID: PMC10493026.

Conde K, Fang S, Xu Y. Unraveling the serotonin saga: from discovery to weight regulation and beyond - a comprehensive scientific review. Cell & Bioscience 2023; 13:143. doi:10.1186/s13578-023-01091-7.

Liu H, Li H, Xu Y. Hunger extends lifespan by modulating histone proteins. Life Metabolism 2023 doi: 10.1093/lifemeta/load024.

Tu L, Bean JC, He Y, Liu H, Yu M, Liu H, Zhang N, Yin N, Han J, Scarlet NA, Conde KM, Wang M, Li Y, Feng B, Gao P, Cai ZL, Fukuda M, Xue M, Tong Q, Yang Y, Liao L, Xu J, Wang C, He Y, Xu Y. Anoctamin 4 channel currents activate glucose-inhibited neurons in the mouse ventromedial hypothalamus during hypoglycemia. Journal of Clinical Investigation 2023 Jun 1;e163391. doi: 10.1172/JCI163391. Online ahead of print.

Xu Y, Jiang Z, Li H, Cai J, Jiang Y, Otiz-Guzman J, Xu Y, Arenkiel BR, Tong Q. Lateral septum as a melanocortin downstream site in obesity development. Cell Reports. 2023 Jun 6;42(6):112626. dio: 10.1016/j.celrep.2023.112626.

Li H, Xu Y, Jiang Y, Jiang Z, Otiz-Guzman J, Morrill JC, Cai J, Mao Z, Xu Y, Arenkiel BR, Huang C, Tong Q. The melanocortin action is biased toward protection from weight loss in mice. Nature Communications (2023) April 17;14(1):2200. dio:10.1038/s41467-023-37912-z. PMID: 37069175. PMCID: PMC10110624.

Han Y, He Y, Harris L, Xu Y, Wu Q. Identification of a GABAergic neural circuit governing leptin signalling deficiency – induced obesity. Elife (2023) April 12;12:e82649. (1):2200. dio: 10.7554/eLife.82649. PMID: 37043384. PMCID: PMC10097419.

Wang M, Yang Y, Xu Y. Brain nuclear receptors and cardiovascular function. Cell & Bioscience (2023) 13:14. doi:10.1186/s13578-023-00962-3.

Liu H, He Y, Bai J, Zhang C, Zhang F, Yang Y, Luo H, Yu M, Liu H, Tu L, Zhang N, Yin N, Han J, Yan Z, Scarcelli NA, Conde KM, Wang M, Bean JC, Potts C, Wang C, Hu F, Liu F and Xu Y. Hypothalamic Grb10 Enhances Leptin Signaling and Promotes Weight Loss. Nature Metabolism 2023 Jan 2. doi:10.1038/s42255-022-00701-x. PMID: 36593271.

He Y, Brouwers B, Liu H, Liu H, Lawler K, Mendes de Oliveira E, Lee DK, Yang Y, Cox AR, Keogh JM, Henning E, Bounds R, Perdikari A, Ayinampudi V, Wang C, Yu M, Tu L, Zhang N, Yin N, Han J, Scarcelli KA, Yan Z, Conde KM, Potts C, Bean JC, Wang M, Hartig SM, Liao L, Xu J, Barroso I, Mokrosinski J, Xu Y, Farooqi SI. Human loss-of-function variants in the Serotonin 2C receptor associated with obesity and maladaptive behaviour. Nature Medicine 2022 Dec 19. doi: 10.1038/s41591-022-02106-5. PMID: 36536256.

Yu M, Bean JC, Liu H, He Y, Yang Y, Cai X, Yu K, Pei Z, Liu H, Tu L, Conde KM, Wang M, Li Y, Yin N, Zhang N, Han J, Scarcelli NA, Xu P, He Y, Xu Y and Wang C. SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis. Cell Biosci 2022 October 9; 12(1): 170. doi:10.1186/s13578-022-00907-2. PMID: 36210455. PMCID: PMC9549684.

Pei Zou, He Y, Bean JC, Yang Y, Yu M, Yu K, Hyseni I, Cai X, Liu H, Na Q, Tu L, Conde KM, Wang M, Li Y, Yin N, Zhang N, Han J, Potts C, Scarcelli NA, Yan Z, Xu P, Wu Q, He Y, Xu Y and Wang C. Gabra5 plays a sexually dimorphic role in POMC neuron activity and glucose balance. Front Endocrinol 2022 August 31;13:889122. doi:10.3389/fendo.2022.889122. PMID: 36120438. PMCID: PMC9471380.

Li VL, He Y, Contrepois K, Liu H, Kim JT, Wiggenhorn AL, Tanzo JT, Tung A, Lyu X, Zushin PH, Jansen RS, Michael B, Loh KY, Yang AC, Carl CS, Voldstedlund CT, Wei W, Terrell SM, Moeller BC, Arthur RM, Wallis GA, Wetering K, Stahl A, Kiens B, Richter EA, Banik SM, Snyder MP, Xu Y, Long JZ. An exercise-inducible metabolite that suppresses food intake and obesity. Nature 2022 Jun 15. doi: 10.1038/s41586-022-04828-5. PMID: 35705806.

Cai X, Liu H, Feng B, Yu M, He Y, Liu H, Yang Y, Tu L, Zhang N, Wang L, Yin N, Han J, Yan Z, Wang C, Xu P, Wu Q, Tong Q, He Y, Xu Y. A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice. Nature Neuroscience 2022 May;25(5):646-658. doi: 10.1038/s41593-022-01062-0.

Tu L, Fukuda M, Tong Q, Xu Y. The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis. Cell & Bioscience 2022; 12:71. https://doi.org/10.1186/s13578-022-00799-2.

Liu H, Cai X, He Y, Xu Y. Hyperactivity of a midbrain dopamine to 5-HT circuit causes anorexia. JMCB May 2022; mjac035, https://doi.org/10.1093/jmcb/mjac035.

Mishra I, Xie WR, Bournat JC, He Y, Wang C, Silva ES, He Y, Liu H, Ku Z, Chen Y, Erokwu BO, Jia P, Zhao Z, An Z, Flask CA, Xu Y, Chopra AR. Protein Tyrosine Phosphatase Receptor δ Serves as the Orexigenic Asprosin Receptor. Cell Metabolism 2022 Apr 5;34(4):549-563.e8. doi: 10.1016/j.cmet.2022.02.012. PMID: 35298903. PMCID: PMC8986618.

Ye H, Feng B, Wang C, Saito K, Yang Y, Ibrahimi L, Schaul S, Patel N, Saenz L, Luo P, Lai P, Torres V, Kota M, Dixit D, Cai X, Qu N, Hyseni I, Yu K, Jiang Y, Tong Q, Sun Z, Arenkiel BR, He Y, Xu P, Xu Y. An estrogen-sensitive hypothalamus-midbrain neural circuit controls thermogenesis and physical activity. Science Advances 2022 Jan 21; (8);eabk0185. doi: 10.1126/sciadv.abk0185. PMID: 35044814. Pmcid: PMC8769556.

Yang Y, He Y, Liu H, Zhou W, Wang C, Xu P, Cai X, Liu H, Yu K, Pei Z, Hyseni I, Fukuda M, Tong Q, Xu J, Sun Z, O'Malley BW, Xu Y. Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition. Cell Reports 2021 Dec 7;37(10):110075. doi: 10.1016/j.celrep.2021.110075. PMID: 34879284.

Yoo ES, Li L, Jia L, Lord CC, Lee CE, Vianna CR, Berglund ED, Cunningham KA, Xu Y, Sohn JW, Liu C. Gαi/o-coupled Htr2c in the Paraventricular Nucleus of the Hypothalamus Antagonizes the Anorectic Effect of Serotonin Agents. Cell Reports. 2021 Nov 16;37(7):109997. doi: 10.1016/j.celrep.2021.109997. PMID: 34788630.

Yan Z, He Y, Cai X, Shu G, Xu Y. Eating for hunger or pleasure: a serotonin model. JMCB September 2021; https://doi.org/10.1093/jmcb/mjab055.

Zhu Y, Li N, Huang M, Bartels M, Dogne S, Zhao S, Chen X, Crewe C, Straub L, Vishvanath L, Zhang Z, Shao M, Yang, Y, Glinkiak CM, Gordilla R, Smith GI, Holland WL, Gupta RK, Dong B, Caron N, Xu Y, Akgul Y, Klein S, Scherer PE. Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis. Nature Communications 2021 Aug 10; 12(1): 4829. Doi: 10.1038/S41467-021-25025-4.

Tu L, Zhang N, Conde KM, Bean JC, Wang C, Xu Y. Free-floating Immunostaining of Mouse Brains. JOVE 2021 Oct 7;(176). doi: 10.3791/62876.

Kaneko K, Lin HY, Fu Y, Saha PK, Puente-Gomez A, Xu Y, Ohinata K, Chen P, Morozov A, Fukuda M. Rap1 in the VMH regulates glucose homeostasis. JCI Insight. 2021 Jun 8;6(11):e142545. doi: 10.1172/jci.insight.142545.

Zhang N, Yan Z, Liu H, Yu M, He Y, Liu H, Liang C, Tu L, Wang L, Yin N, Han J, Scarcelli N, Yang Y, Wang C, Zeng T, Chen LL, Xu Y. Hypothalamic perineuronal nets are regulated by sex and dietary interventions. Frontiers in Physiology 28 July 2021 | https://doi.org/10.3389/fphys.2021.714104.

He Y, Cai X, Liu H, Conde KM, Xu P, Li Y, Wang C, Yu M, He Y, Liu H, Liang C, Yang T, Yang Y, Yu K, Wang J, Zheng R, Liu F, Sun Z, Heisler L, Wu Q, Tong Q, Zhu C, Shu G, Xu Y. 5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding. Molecular Psychiatry 2021 Jul 21. doi: 10.1038/s41380-021-01220-z.

He Y, Liu H, Yin N, Yang Y, Wang C, Yu M, Liu H, Liang C, Wang J, Tu L, Zhang N, Wang L, He Y, Fukuda M, Wu Q, Sun Z, Tong Q, Xu Y. Barbadin potentiates long-term effects of lorcaserin on POMC neurons and weight loss. Journal of Neuroscience 2021 Jun 30;41(26):5734-5746. doi: 10.1523/JNEUROSCI.3210-20.2021.

Han Y, Xia G, Srisai D, Meng F, He Y, Ran Y, He Y, Farias M, Hoang G, Tóth I, Dietrich M, Chen MH, Xu Y, and Wu Q. Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding. Nature Communications 2021 Jun 10;12(1):3525. doi: 10.1038/s41467-021-23846-x.

Han Y, Xia G, He Y, He Y, Farias M, Xu Y, Wu Q. A hindbrain dopaminergic neural circuit prevents weight gain by reinforcing food satiation. Science Advances. 2021 May 26;7(22):eabf8719. doi: 10.1126/sciadv.abf8719.

Mishra I, Duerrschmid C, Ku Z, He Y, Xie W, Silva ES, Hoffmann J, Xin W, Zhang N, Xu Y, An Z, Chopra AR. Asprosin Neutralizing Antibodies as a Treatment for Metabolic Syndrome. Elife 2021 Apr 27;10:e63784. doi: 10.7554/eLife.63784.

Ding Y, Liu Y, Lee DK, Tong Z, Yu X, Li Y, Xu Y, Lanz RB, O'Malley BW, Xu J. Cell Lineage Tracing Links Estrogen Receptor α Loss in Erbb2-Positive Breast Cancers to the Arising of a Highly Proliferative and Metastatic Breast Cancer Subtype. PNAS 2021 May 25;118(21):e2100673118. doi: 10.1073/pnas.2100673118.

Fan S, Xu Y, Lu Y, Jiang Z, Li H, Morrill J, Cai J, Wu Q, Xu Y, Xue M, Arenkiel B, Huang C and Tong Q. A Neural Basis for Brain Leptin Action on Reducing Type 1 Diabetic Hyperglycemia. Nature Communications 2021 May 11;12(1):2662. doi: 10.1038/s41467-021-22940-4.

Liu T, Xu Y, Yi CX, Tong Q, Cai D. The hypothalamus for whole-body physiology: from metabolism to aging. Protein Cell 2021 April. PMID: 33826123 DOI: 10.1007/s13238-021-00834-x.

Xia G, Han Y, Meng F, He Y, Srisai D, Farias M, Dang M, Palmiter RD, Xu Y and Wu Q. Reciprocal control of obesity and anxiety-depressive disorder via a GABA and serotonin neural circuit. Molecular Psychiatry 2021. https://doi.org/10.1038/s41380-021-01053-w. PMID: 33762728.

Ding G, Li X, Hou X, Zhou W, Gong Y, Liu F, He Y, Song J, Wang J, Basil P, Li W, Qian S, Saha P, Wang J, Cui C, Yang T, Zou K, Han Y, Amos CI, Xu Y, Chen L, Sun Z. Rev-erb in GABAergic Neurons Controls Diurnal Hepatic Insulin Sensitivity. Nature 2021. https://doi.org/10.1038/s41586-021-03358-w.

Wang Y, Yang Y, Wang M, Wang S, Jeong JM, Xu L, Wen Y, Emontzpohl C, Atkins CL, Duong K, Moreno NF, Yuan X, Hall DR, Dar W, Feng D, Gao B, Xu Y, Czigany Z, Colgan SP, Bynon JS, Akira S, Brown JM, Eltzschig HK, Jacobsen EA, Ju C. Eosinophils attenuate hepatic ischemia-reperfusion injury in mice through ST2-dependent IL-13 production. Science Translational Medicine. Feb 2021: Vol. 13, Issue 579, eabb6576. DOI: 10.1126/scitranslmed.abb6576. PMID: 33536281.

Wang C, Zhou W, He Y, Yang T, Xu P, Yang Y, Cai X, Wang J, Liu H, Yu M, Liang C, Yang T, Liu H, Fukuda M, Tong Q, Wu Q, Sun S, He Y, Xu Y. AgRP neurons trigger long-term potentiation and facilitate food seeking. Translational Psychiatry 2021 Jan 5;11(1):11. doi: 10.1038/s41398-020-01161. PMID: 33414382.

Liu H, Wang C, Yu M, Yang Y, He Y, Liu H, Liang C, Tu L, Zhang N, Wang L, Wang J, Liu F, Hu F, Xu Y. TPH2 in the dorsal Raphe nuclei regulates energy balance in a sex-dependent manner. Endocrinology 2021, Vol. 162, No. 1, 1–16 | doi:10.1210/endocr/bqaa183.

Liu H, He Y, Beck J, Teixeira S, Harrison K, Xu Y, Sisley S. Defining VDR expression in the brain using a novel VDRCre mouse. The Journal of Comparative Neurology 2020 Dec 25. doi: 10.1002/cne.25100. PMID: 33368246.

Zhang Z, Reis F, He Y, Park JW, DiVittorio JR, Sivakumar N, van Veen JE, Pereira S, Shum M, Anderson S, Nichols I, Paul K, Liesa M, Ajijola OA, Xu Y, Adhikari A, Correa SM. Estrogen-sensitive medial preoptic area neurons coordinate hypothermia and hypometabolism in mice. Nature Communications 2020, 11:6378 | https://doi.org/10.1038/s41467-020-20050-1.

Yang Y, Xu Y. The central melanocortin system and human obesity. Journal of Molecular and Cell Biology 2020 Sep 25;mjaa048. doi: 10.1093/jmcb/mjaa048. PMID: 32976556.

Liu H, Xu Y, Hu F. AMPK in the Ventromedial Nucleus of the Hypothalamus: a Key Regulator for Thermogenesis. Frontiers in Endocrinology 2020 September 23; (11).

Yu K, He Y, Hyseni I, Pei Z, Yang Y, Xu P, Cai X, Liu H, Qu N, Liu H, He Y, Yu M, Liang C, Yang T, Wang J, Gourdy P, Arnal JF, Lenfant F, Xu Y and Wang C. 17β-estradiol promotes acute refeeding in hungry mice by membrane-initiated ERα signaling. Molecular Metabolism 2020 July 23; (42) 101053. PMID: 32712433. doi: 10.1016/j.molmet.2020.101053.

Kim ER, Xu Y, Cassidy RM, Lu Y, Yang Y, Tian J, Li DP, Drunen RV, Ribas-Latre A, Cai ZL, Xue M, Arenkiel BR, Eckel-Mahan K, Xu Y, Tong Q. Paraventricular hypothalamus mediates diurnal rhythm of metabolism. Nature Communications 2020 July 30;11:3794. PMID: 32732906. PMCID: PMC7393104. doi: 10.1038/s41467-020-17578-7.

Sun Z and Xu Y. Nuclear Receptor Coactivators (NCOAs) and Corepressors (NCORs) in the Brain. Endocrinology 2020 Aug 1;161(8):bqaa083. doi: 10.1210/endocr/bqaa083. PMID: 32449767. PMCID: PMC7351129.

Zhu C, Jiang Z, Xu Y, Cai ZL, Jiang Q, Xu Y, Xue M, Arenkiel RB, Wu Q, Shu G and Tong Q. Profound and Redundant Functions of Arcuate Neurons in Obesity Development. Nature Metabolism 2020 August; 2(8):763-774. doi: 10.1038/s42255-020-0229-2. PMID: 32719538.

He Y, Xu P, Wang C, Xia Y, Yu M, Yang Y, Yu K, Cai X, Qu N, Saito K, Wang J, Hyseni I, Robertson M, Piyarathna B, Gao M, Khan SA, Liu F, Chen R, Coarfa C, Zhao Z, Tong Q, Sun Z, Xu Y. Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance. Nature Communications 2020 May 1;11(1):2165. doi: 10.1038/s41467-020-15982-7. PMID: 32358493.

Zhu C, Xu Y, Jiang Z, Tian JB, Cassidy RM, Cai Z, Shu G, Xu Y, Xue M, Arenkiel BR, Jiang Q and Tong Q. Disrupted hypothalamic CRH neuron responsiveness contributes to diet-induced obesity. EMBO Reports 2020 Jul 3;21(7):e49210. doi: 10.15252/embr.201949210.

Teixeira S, Harrison K, Uzodike M, Rajapakshe K, Coarfa C, He Y, Xu Y, Sisley S. Vitamin D actions in neurons require the PI3K pathway for both enhancing insulin signaling and rapid depolarizing effects. Journal of Steroid Biochemistry and Molecular Biology 2020 Jun; 200:105690. doi: 10.1016/j.jsbmb.2020.105690.

Wooton-Kee CR, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH, Liu H, Xu Y, Putluri N, Saha P, Coarfa C, Moore DD, and Nuotio-Antar AM. Metabolic dysregulation in the Atp7b−/− Wilson's disease mouse model. PNAS first published January 10, 2020 https://doi.org/10.1073/pnas.1914267117.

Hua X, Wang YY, Jia P, Xiong Q, Hu Y, Chang Y, Lai S, Xu Y, Zhao Z, Song J. Multi-level transcriptome sequencing identifies COL1A1 as a candidate marker in human heart failure progression. BMC Med. 2020 Jan 6;18(1):2. doi: 10.1186/s12916-019-1469-4.

Qu N, He Y, Wang C, Xu P, Yang Y, Cai X, Liu H, Yu K, Pei Z, Hyseni I, Sun Z, Fukuda M, Li Y, Tian Q, Xu Y. A POMC-originated circuit regulates stress-induced hypophagia, depression and anhedonia. Molecular Psychiatry 2019 Sep 5. doi: 10.1038/s41380-019-0506-1. PMID: 31485012.

Kaneko K, Fu Y, Lin HY, Cordonier EL, Mo Q, Gao Y, Yao T, Naylor J, Howard V, Saito K, Xu P, Chen SS, Chen MH, Xu Y, Williams KW, Ravn P, Fukuda M. Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition. The Journal of Clinical Investigation 2019 Aug 12;130:3786-3791. doi: 10.1172/JCI126107. PMID: 31403469.

Xu Y, Lu Y, Cassidy R, Mangieri L, Zhu C, Huang X, Jiang Z, Justice N, Xu Y, Arenkiel B, and Tong Q. Identification of a neurociruit underlying regulation of feeding by stress-related emotional responses. Nature Communications 2019 Aug 1;10(1):3446. doi: 10.1038/s41467-019-11399-z. PMID: 31371721; PMCID: PMC6671997.

Mangieri L, Jiang Z, Lu Y, Xu Y, Cassidy R, Justice N, Xu Y, Arenkiel B, Tong Q. Defensive behaviors driven by a hypothalamic-ventral midbrain circuit. eNeuro 2019 Jul 29;6(4). pii: ENEURO.0156-19.2019. doi: 10.1523/ENEURO.0156-19.2019. PMID: 31331938; PMCID: PMC6664144.

Zhang W, Wu X, Pei Z, Kiess W, Yang Y, Xu Y, Chang Z, Wu J, Sun C, Luo F. GDF5 Promotes White Adipose Tissue Thermogenesis via p38 MAPK Signaling Pathway. DNA and Cell Biology 2019 Nov;38(11):1303-1312. doi: 10.1089/dna.2019.4724.

Yang Y, van der Klaauw AA, Zhu L, Cacciottolo TM, He Y, Stadler L, Wang C, Xu P, Saito K, Hinton Jr. A, Yan X, Keogh JM, Henning E, Banton MC, Hendricks AE, Bochukova EG, Mistry V, Lawler KL, Liao L, Xu J, O'Rahilly S, Tong Q, UK10K consortium, Barroso I, O'Malley BW, Farooqi IS, Xu Y. Steroid Receptor Coactivator-1 Modulates the Function of Pomc Neurons and Energy Homeostasis. Nature Communications, 2019 Apr 12;10(1):1718. doi: 10.1038/s41467-019-08737-6. PMID: 30979869. PMCID: PMC6461669.

Cassidy RM, Lu Y, Jere M, Tian JB, Xu Y, Mangieri LR, Felix-Okoroji B, Selever J, Xu Y, Arenkiel BR, Tong Q. A lateral hypothalamus to basal forebrain neurocircuit promotes feeding by suppressing responses to anxiogenic environmental cues. Science Advances. 2019 Mar 6;5(3):eaav1640. doi: 10.1126/sciadv.aav1640. eCollection 2019 Mar. PMID: 30854429. PMCID: PMC6402846.

Wang C and Xu Y. Mechanisms for sex differences in energy homeostasis. Journal of Molecular Endocrinology 2019 Feb;62(2):R129-R143. doi: 10.1530/JME-18-0165. PMID: 31130779. PMCID: PMC6528488.

Yan H, Yang W, Zhou F, Li X, Pan Q, Shen Z, Han G, Newell-Fugate A, Tian Y, Majeti R, Liu W, Xu Y, Wu C, Allred K, Allred C, Sun Y and Guo S. Estrogen improves insulin sensitivity and suppresses gluconeogenesis via the transcription factor Foxo1. Diabetes, 2019 Feb; 68(2):291-304. PMID: 30487265. PMCID: PMC6341301.

Zhou W, He Y, Rehman AU, Kong Y, Hong S, Ding G, Yalamanchili HK, Wan YW, Paul B, Wang C, Gong Y, Zhou W, Liu H, Dean J, Scalais E, O'Driscoll M, Morton J, Hou X, Wu Q, Tong Q, Liu Z, Liu P, Xu Y, and Sun Z. NCOR1/2 loss of function impairs memory through a novel GABAergic hypothalamus–CA3 projection. Nature Neuroscience 2019 Feb;22(2):205-217. doi: 10.1038/s41593-018-0311-1. PMID: 30664766. PMCID: PMC6361549.

Bai J, Cervantes, C, Liu J, He S, Zhou H, Zhang B, Cai H, Yin D, Hu D, Li Z, Chen H, Gao X, Wang F, O'Connor JC, Xu Y, Liu M, Dong LQ, Liu F. DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing mtDNA release-activated cGAS-cGAMP-STING pathway. Proc Natl Acad Sci USA 2017 Nov 14;114(46):12196-12201. doi: 10.1073/pnas.1708744114. PMID: 29087318.

Duerreschmid C, He Y, Wang C, Li C, Bournat J, Romere C, Saha PK, Phillps KJ, Jain P, Jia P, Zhao Z, Farias M, Wu Q, Milewicz DM, Suton VR, Moore DD, Butte NF, Krashes MJ, Xu Y, Chopra AR. Asprosin is a centrally-acting orexigenic hormone. Nature Medicine 2017 Nov 6. doi: 10.1038/nm.4432. PMID: 29106398.

Zhu C, Xu P, He Y, Yuan Y, Wang T, Cai X, Yu L, Yang L, Wu J, Wang L, Zhu X, Wang S, Gao P, Xi Q, Zhang Y, Xu Y, Jiang Q, Shu G. Heparin increases food intake through AgRP neurons. Cell Reports 2017 Sep 5;20(10):2455-2467. doi: 10.1016/j.celrep.2017.08.049. PMID: 28877477.

Xu Y, Lu Y, Xu P, Mangieri LR, Isingrini E, Xu Y, Giros B, Tong Q. VMAT2-Mediated Neurotransmission from Midbrain Leptin Receptor Neurons in Feeding Regulation. eNeuro. 2017 May 26;4(3). pii: ENEURO.0083-17.2017. doi: 10.1523/ENEURO.0083-17.2017. eCollection 2017 May-Jun. PMID: 285603156.

Wu CS, Bongmba O, Yue J, Lee YH, Lin L, Saito K, Pradhan G, Li DP, Pan HK, Xu A,
Guo S, Xu Y, Sun Y. Suppression of GHS-R in AgRP neurons mitigates diet-induced obesity by activating thermogenesis. The International Journal of Mechanical Sciences 2017 Apr 14;18(4). pii: E832. doi: 10.3390/ijms18040832. PMID: 28420089. PMCID: PMC5412416.

Xu Y, O'Malley BW, Elmquist JK. Brain nuclear receptors and body weight regulation. The Journal of Clinical Investigation 2017 Apr 3;127(4):1172-1180. doi: 10.1172/JCI88891. PMID: 28218618.

Xu P, Zhu L, Saito K, Yang Y, Wang C, He Y, Xia Y, Hyseni Ilirjana, Tong Q, Xu Y. Melanocortin 4 receptor is not required for estrogenic regulations on energy homeostasis and reproduction. Metabolism 2017 May; 70: 152-159.

Hinton A, Yang Y, Qick AP, Xu P, Reddy Chitra, Xia Y, Reynolds Corey, Tong Q, Zhu L, Xu J, Wehrens Xander, Xu Y, Reddy Anihumar. SRC-1 regulates blood pressure and aortic stiffness in female mice. Plos One 2016 Dec 22;11(12):e0168644. doi: 10.1371/journal.pone.0168644. eCollection 2016.

He Y, Shu G, Xu P, Yang Y, Xia Y, Wang C, Saito K, Hinton A, Yan X, Liu C, Wu Q, Tong Q, Xu Y. A small potassium current in AgRP/NPY neurons regulates feeding behavior and energy metabolism. Cell Reports 2016 November 8; 17: 1807-1818.

Kaneko K, Xu P, Ng A, Xu Y, Elmquist JK, Morozov A, Fukuda M. Neuronal Rap1 regulates energy balance, glucose homeostasis, and leptin actions. Cell Reports 2016 Sep 13;16(11):3003-15. doi: 10.1016/j.celrep.2016.08.039. PMID: 27626668. PMCID: PMC5024738.

Xu P, He Y, Cao X, Valencia-Torres L, Yan X, Saito K, Wang C, Yang Y, Hinton Jr. A, Zhu L, Shu G, Myers Jr. MG, Wu Q, Tong Q, Heisler LK, Xu Y. Activation of serotonin 2C receptors in dopamine neurons inhibits binge-like eating in mice. Biological Psychiatry (highlighted as Priority Communication). 2016 Jun 9. pii: S0006-3223(16)32470-2. doi: 10.1016/j.biopsych.2016.06.005. PMID: 27516377.

Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Chen S, Gardner D, Seeley RJ, Sandoval DA. Hypothalamic vitamin D improves glucose homeostasis and improves weight. Diabetes 2016 May 23. pii: db160309. PMID: 27217488.

Hu F, Xu Y, Liu F. Hypothalamic Roles of mTOR Complex I: Integration of nutrient and hormone signals to regulate energy homeostasis. AJP-Endocrinology and Metabolism 2016 Jun 1;310(11):E994-E1002. doi: 10.1152/ajpendo.00121.2016. PMID: 27166282. PMCID: PMC4935144.

Lee JH, Lin L, Xu P, Saito K, Wei Q, Meadows AG, Bongmba O, Pradhan G, Zheng H, Xu Y, Sun Y. Neuronal deletion of ghrelin receptor almost completely prevents diet-induced obesity. Diabetes 2016 Aug;65(8):2169-78. doi: 10.2337/db15-1587. PMID: 27207529. PMCID: PMC4955988.

Hinton A, He Y, Xia Y, Xu P, Yang Y, Saito K, Wang C, Yan X, Shu G, Henderson A, Clegg DJ, Khan SA, Reynolds C, Wu Q, Tong Q, Xu Y. Estrogen receptor-α in the medial amygdala prevents stress-induced elevations in blood pressure in females. Hypertension 2016 Apr 18. Epub 2016 Apr 18. doi: 10.1161/HYPERTENSIONAHA.116.07175. PMID: 27091896. PMCID: PMC4865414.

Saito K, He Y, Yang Y, Zhu L, Wang C, Xu P, Hinton A, Yan X, Zhao J, Fukuda M, Tong Q, Clegg DJ, Xu Y. PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on 2 energy expenditure in female mice. Scientific Reports-Nature 2016 March 18:6: 23459. doi: 10.1038/srep23459 PMID: 26988598; PMCID: PMC4796901.

Meng F, Han Y, Srisai D, Belakhov V, Farias M, Xu Y, Palmiter RD, Baasov T, Wu Q. A new inducible genetic method reveals critical roles of GABA in the control of feeding and metabolism. Proc Natl Acad Sci USA 2016 Mar 29; 113(13)3645-50. pii: 201602049. PMID: 26976589.

Saito K, He Y, Yan X, Yang Y, Wang C, Xu P, Hinton Jr. A, Shu G, Yu L, Tong Q, Xu Y. Visualizing estrogen receptor-α-expressing neurons using a new ERα-ZsGreen reporter mouse line. Metabolism 2016 Apr;65(4):522-32. doi: 10.1016/j.metabol.2015.12.011. PMID:26975544.

Xu Y, Chang JT, Myers Jr. MG, Xu Y, Tong Q. Euglycemia restoration by central leptin in Type 1 diabetes requires STAT3 signaling but not fast-acting neurotransmitter release. Diabetes 2016 Jan 28. pii: db151160. PMID: 26822087.

Fan S, Dakshinamoorthy J, Kim ER, Xu Y, Huang C, and Tong Q. An indirect action contributes to c-fos induction in paraventricular hypothalamic nucleus by neuropeptide Y. Scientific Reports-Nature 2016 Jan 27;6:19980. doi: 10.1038/srep19980. PMID 26813148. PMCID: PMC4728490.

Zhu L, Xu P, Cao X, Yang Y, Hinton A, Xia Y, Saito K, Yan X, Zou F, Ding F, Wang C, Yan C, Saha P, Khan SA, Zhao J, Fukuda M, Tong Q, Clegg DJ, Chan L, Xu Y. The ERα-PI3K cascade in pro-opiomelanocortin progenitor neurons regulates feeding and glucose balance in female mice. Endocrinology 2015 Dec; 156(12)4474-91. PMID: 26375425.

Yan C, He Y, Xu Y, Shu G, Wang C, Yang Y, Saito K, Xu P, Hinton A, Yan X, Yu L, Wu Q, Tso P, Tong Q, Xu Y. Apolipoprotein A-IV inhibits AgRP/NPY neurons and activates POMC neurons in the arcuate nucleus. Neuroendocrinology 2015 August 25. PMID: 26337236.

Xu P, Cao X, Xu Y. Physical activity controlled by estrogen signals in the medial amygdala. Receptors & Clinical Investigation 2015; 2: e975. dio:10.14800/rci.975.

Xu P, Cao X, Xu Y. Targeting brain estrogen receptor for binge eating. Oncotarget 2015 August 22. PMID: 26309082.

Xu P, Cao X, He Y, Zhu L, Yang Y, Saito K, Wang C, Yan X, Hinton A, Zou F, Ding H, Xia Y, Yan C, Wu SP, Yang B, Feng Y, Clegg DJ, DiMarchi R, Khan SA, Tsai SY, DeMayo FJ, Wu Q, Tong Q, Xu Y. Estrogen receptor-α in medial amygdala neurons regulates body weight. The Journal of Clinical Investigation 2015 Jul 1;125(7):2861-76. PMID: 26098212.

Saito K, Cao X, He Y, Xu Y. Progress in the molecular understanding of central regulation of body weight by estrogens. Obesity. 2015 May;23(5):919-26. PMID: 25865677. PMCID: PMC4414873.

Zhu L, Zou F, Yang Y, Xu P, Saito K, Hinton A, Yan X, Ding H, Wu Q, Fukuda M, Sun Z, Tong Q, Xu Y. Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice. Endocrinology. 2015 Jun; 156(6):2114-23. PMID: 25807042.

Yan C, Yang Y, Saito K, Xu P, Wang C, Hinton A, Yan X, Wu Q, Tong Q, Elmquist JK, Fukuda M, Xu Y. Meta-Chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice. British Journal of Pharmacology. 2015 Mar 27. doi: 10.1111/bph.13141. PMID: 25817043.

Wu Z, Kim ER, Sun H, Xu Y, Mangieri LR, Li DP, Pan HL, Xu Y, Arenkiel BR, Tong Q. GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding. The Journal of Neuroscience. 2015 Feb 25; 35(8):3312-8. PMID: 25716832.

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