Center for Drug Discovery Publications & Grants




The following is a listing of publications from the members of the Center for Drug Discovery. They demonstrate the significant body of research work being conducted at Baylor College of Medicine in the area of drug discovery. 


Du HC, Huang H. DNA-Compatible Nitro Reduction and Synthesis of Benzimidazoles. Bioconjug Chem. 2017, Oct 18; 28 (10):  2575-2580. DOI: 10.1021

Li JY, Huang, H. Development of DNA-Compatible Suzuki-Miyaura Reaction in Aqueous Media. Bioconjug Chem. 2018, Nov 21; 29(11):  3841-3846. DOI:  10.1021

Du HC, Bangs MC, Simmons N, Matzuk MM. Multistep Synthesis of 1,2,4-Oxadiazoles via DNA-Conjugated Aryl Nitrile Substrates. Bioconjug Chem. 2019, May 15; 30(5):  1304-1308. DOI: 10.1021

Li JY, Miklossy G, Modukuri RK, Bohren KM, Yu Z, Palaniappan M, Faver JC, Riehle K, Matzuk MM, Simmons N. Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis. Bioconjug Chem. 2019, Aug 21; 30(8):  2209-2215. DOI: 10.1021/acs.bioconjchem.9b00447

Faver JC, Riehle K, Lancia DR Jr, Milbank JBJ, Kollmann CS, Simmons N, Yu Z, Matzuk MM.  Quantitative Comparison of Enrichment from DNA-Encoded Chemical Library Selections. ACS Comb Sci. 2019, Feb 11; 21(2):75-82. doi: 10.1021/acscombsci.8b00116

Du HC, Simmons N, Faver JC, Yu Z, Palaniappan M, Riehle K, Matzuk MM. A Mild, DNA-Compatible Nitro Reduction Using B2(OH)4.  Org Lett.  2019, Apr 5; 21(7):  2194-2199. doi: 10.1021/acs.orglett.9b00497

Monty OBC, Nyshadham P, Bohren KM, Palaniappan M, Matzuk MM, Young DW, Simmons N. Homogeneous and Functional Group Tolerant Ring-Closing Metathesis for DNA-Encoded Chemical Libraries. ACS Comb. Sci. 2020.


Extramural Grants Awards


Molecular Mechanisms of Fluoroquinolone Resistance, NIH. Grant # 1R01GM115501. 07/2015-06/2019. Zechiedrich, Lynn.

Loan Repayment Program award, Eunice Kennedy Shriver National Institute of Child Health and Human Development. Grant # L50 HD085320-01. 2015-2017. Matzuk, Martin.

Activation and Regulation Mechanism of CGMP-Dependent Protein Kinase I and II, NIGMS R01 GM090161. 2015-2016. Kim, Choel Woong.

A Novel Approach to identify inhibitors of androgen receptor splice variants. DOD HDA W81XWH-15-0077 Weigel (PI). 04/15/15-04/14/16.

GATA2 and Steroid Receptor Coactivator-2 Cooperate with androgen Receptor in Prostate cancer Progression and Androgen Resistance. RP150648 MIRA O’Malley (PI), Weigel Project 2 leader, 06/01/15-05/31/20.