Department of Psychiatry and Behavioral Sciences

Mood and Anxiety Disorders Program Research Studies


Our current studies and a brief description of each are listed below. More information about these studies, including eligibility criteria, funding sources, and team members involved can be found by clicking the study’s name. For more information for how to participate in a research study please see How to Participate.

Major Depressive Disorder

Merck sponsored Major Depressive Disorder Study
This study will test a study drug to see if it could help reduce symptoms of depression.

Treatment-Resistant Depression

Electroconvulsive therapy versus Ketamine for Severe Resistant Depression (ELEKT-D)
The goal of this study is to conduct a comparative effectiveness trial of ECT vs. intravenous ketamine in patients with treatment-resistant major depressive disorder.

Augmentation vs Switch: Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders with Treatment-Resistant Depression (ASCERTAIN-TRD) 
The goal of this study is to compare the effectiveness of repetitive Transcranial Magnetic Stimulation (rTMS), aripiprazole, or venlafaxine XR for patients with major depressive disorder who have shown an inadequate treatment response to at least 2 treatments. 

Other Studies

Glutamate receptor and kynurenine pathway functioning in the pathobiology of Gulf War Illness 
The goal of this project is to test neuroinflammatory pathways and NMDA receptor functioning in a well-characterized group of 1990-1991 Gulf War veterans.

Mechanisms, prediction and treatment of short-term risk for suicidal behavior
The goal of this project is to compare behavioral and neurophysiological indicators of impulsivity, sensitization, and affect regulation in high-suicide risk subjects, and investigate the effects of lithium treatment on these variables.

Associated Studies

A Clinical Pilot Study Examining Bilateral Inhibition of the Lateral Habenula as a Target for Deep Brain Stimulation in Intractable Depression