Allan Chris Ferreon, Ph.D.
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Positions
- Associate Professor
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Biochemistry and Molecular Pharmacology
Baylor College of Medicine
Houston, Texas USA
Addresses
- BCM-Alkek Graduate School (Office)
-
Room: BCMN-N520.02
Houston, TX 77030
United States
Education
- Post-Doctoral Fellowship at The Scripps Research Institute
- La Jolla, California USA
- Single Molecule Biophysics
- PhD from University of Texas Medical Branch
- Galveston, Texas USA
- Structural Biology and Biophysical Chemistry
- BS from University of the Philippines-Diliman
- Quezon City, Philippines
- Molecular Biology & Biotechnology
Honors & Awards
- Ruth L. Kirschstein National Research Service Award Postdoctoral Fellow
- National Institute of Neurological Disorders and Stroke, National Institutes of Health, USA
- Sealy Center for Structural Biology Pre-Doctoral Fellow
- University of Texas Medical Branch, Galveston, Texas, USA
Professional Interests
- Single Molecule Biophysics
- Bioanalytical Chemistry
- Intrinsically Disordered Proteins
- Protein Folding and Misfolding
- Macromolecular Interactions
Websites
Selected Publications
- Moosa MM, Ferreon ACM* and AA Deniz* [*co-corresponding authors] "Forced folding of a disordered protein accesses an alternative folding landscape.." Chemphyschem. 2014; Pubmed PMID: 25345588
- Ferreon ACM*, JC Ferreon*, PE Wright and AA Deniz [*co-first authors] "Modulation of allostery by protein intrinsic disorder.." Nature. 2013;498(7454):390-4. Pubmed PMID: 23783631
- Ferreon ACM, MM Moosa, Y Gambin and AA Deniz "Counteracting chemical chaperone effects on the single-molecule α-synuclein structural landscape. (Direct Submission)." Proc. Natl. Acad. Sci. USA. 2012;109(44):17826-31. Pubmed PMID: 22826265
- Ferreon ACM and AA Deniz "Osmolyte-, binding-, and temperature-induced transitions of intrinsically disordered proteins. (Book Chapter)." Methods Mol. Biol.. 2012;896:257-66. Pubmed PMID: 22821530
- Ferreon ACM and AA Deniz "Protein folding at single-molecule resolution. (Review)." BBA- Proteins and Proteomics. 2011;1814(8):1021-9. Pubmed PMID: 21303706
- Gambin Y, V Vandelinder, ACM Ferreon, EA Lemke, A Groisman and AA Deniz "Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing.." Nature Methods. 2011;8(3):239-41. Pubmed PMID: 21297620
- Lee CW, JC Ferreon, ACM Ferreon, M Arai and PE Wright "Graded enhancement of p53 binding to CBP by multisite phosphorylation.." Proc. Natl. Acad. Sci. USA. 2010;107(45):19290-5. Pubmed PMID: 20962272
- Ferreon ACM, CR Moran, Y Gambin and AA Deniz "Single-molecule fluorescence studies of intrinsically disordered proteins. (Book Chapter)." Methods Enzymol.. 2010;472:179-204. Pubmed PMID: 20580965
- Ferreon ACM, CR Moran, JC Ferreon and AA Deniz "Alteration of the alpha-synuclein folding landscape by a mutation related to Parkinson’s disease.." Angew. Chem. Int. Ed.. 2010;49:3469-72. Pubmed PMID: 20544898
- Vandelinder V, ACM Ferreon, Y Gambin, AA Deniz and A Groisman "High-resolution temperature-concentration diagram of alpha-synuclein conformation obtained from a single Förster resonance energy transfer image in a microfluidic device.." Anal. Chem.. 2009;81(16):6929-35. Pubmed PMID: 19555081
- Gambin Y, A Schug, EA Lemke, JJ Lavinder, ACM Ferreon, TJ Magliery, JN Onuchic and AA Deniz "Direct single-molecule observation of a protein living in two opposed native structures.." Proc. Natl. Acad. Sci. USA. 2009;106(25):10153-8. Pubmed PMID: 19506258
- Ferreon ACM, Y Gambin, EA Lemke and AA Deniz "Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence. (Direct Submission)." Proc. Natl. Acad. Sci. USA. 2009;106(14):5645-50. Pubmed PMID: 19293380
- Ferreon ACM and AA Deniz "Alpha-synuclein multistate folding thermodynamics: Implications for protein misfolding and aggregation.." Biochemistry. 2007;46(15):4499-509. Pubmed PMID: 17378587
- Ferreon ACM, JC Ferreon, DW Bolen and J Rösgen "Protein phase diagrams II: Nonideal behavior of biochemical reactions in the presence of osmolytes.." Biophys. J.. 2007;92(1):245-56. Pubmed PMID: 17028144
- Auton M, ACM Ferreon and DW Bolen "Metrics that differentiate the origins of osmolyte effects on protein stability: A test of the surface tension proposal.." J. Mol. Biol.. 2006;361(5):983-92. Pubmed PMID: 16889793
- Ferreon JC, ACM Ferreon, K Li and SM Lemon "Molecular determinants of TRIF proteolysis mediated by the hepatitis C virus NS3/4A protease.." J. Biol. Chem.. 2005;280(21):20483-92. Pubmed PMID: 15767257
- Li K, E Foy, JC Ferreon, M Nakamura, ACM Ferreon, M Ikeda, SC Ray, M Gale, Jr. and SM Lemon "Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. (Direct Submission)." Proc. Natl. Acad. Sci. USA. 2005;102(8):2992–7. Pubmed PMID: 15710891
- Ferreon ACM and DW Bolen "Thermodynamics of denaturant-induced unfolding of a protein that exhibits variable two-state denaturation.." Biochemistry. 2004;43(42):13357-69. Pubmed PMID: 15491142
- Yang M, ACM Ferreon and DW Bolen "Structural thermodynamics of a random coil protein in guanidine hydrochloride.." Proteins Suppl 4.;44-9. Pubmed PMID: 11013399
- Halos SC, JY Chu, ACM Ferreon and MMF Magno "Philippine population database at nine microsatellite loci for forensic and paternity applications.." Forensic Sci. Int.. 1999;101(1):27-32. Pubmed PMID: 10376334
- Halos SC, ES Fortuno III, ACM Ferreon, JY Chu, J Miranda, S Harada and M Benecke "Allele frequency distributions of the polymorphic STR loci HUMVWA, HUMFES, HUMF13A01 and the VNTR D1S80 in a Filipino population from Metro Manila.." Int. J. Legal Med.. 1998;111(4):224-6. Pubmed PMID: 9646171
Memberships
- Biophysical Society
- Protein Society
Languages
Tagalog, Pangasinan
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